Frontiers in Medicinal Chemistry

Volume 7

by

Atta-ur-Rahman , M. Iqbal Choudhary , Jizhou Wang, Allen B. Reitz

DOI: 10.2174/97816080597061150701
eISBN: 978-1-60805-970-6, 2015
ISBN: 978-1-60805-971-3
ISSN: 1567-2042 (Print)
ISSN: 1875-5763 (Online)



Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory.

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Bacterial Protein Toxins: Current and Potential Clinical Use

- Pp. 274-312 (39)

Alessia Fabbri, Francesca Rosadi, Giulia Ballan, Antonella Del Brocco, Sara Travaglione, Stefano Loizzo and Carla Fiorentini

Abstract

Natural toxins are the product of a long-term evolution, and act on essential mechanisms in the most crucial and vital processes of living organisms. They can attack components of the protein synthesis machinery, actin polymerization, signal transduction pathways, intracellular trafficking of vesicles as well as immune and inflammatory responses. For this reason, toxins have increasingly been used as valuable tools for analysis of cellular physiology, and in the recent years, some of them are used medicinally for the treatment of human diseases. </p><p> This review is devoted to protein toxins of bacterial origin, specifically those toxins that are currently used in therapy or those under study for their potential clinical applications. Bacterial protein toxins are all characterized by a specific mechanism of action that involves the central molecular pathways in the eukaryotic cell. Knowledge of their properties could be used for medical purposes.

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