Frontiers in Computational Chemistry

Volume 2

by

Zaheer Ul-Haq, Jeffry D. Madura

DOI: 10.2174/97816080597821150201
eISBN: 978-1-60805-978-2, 2015
ISBN: 978-1-60805-979-9
ISSN: 2352-944X (Print)
ISSN: 2352-9458 (Online)



Indexed in: Book Citation Index, Science Edition, BIOSIS Previews, EBSCO.

Frontiers in Computational Chemistry presents contemporary research on molecular modeling techniques used in drug discovery and the dr...[view complete introduction]
US $
Buy Personal eBook
165
Order Library eBook
660
Order Printed Copy
*165
Order PDF + Printed Copy (Special Offer)
*247

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Also available:
Download Flyer

Data Quality Assurance and Statistical Analysis of High Throughput Screenings for Drug Discovery

- Pp. 389-425 (37)

Yang Zhong, Zuojun Guo and Jianwei Che

Abstract

High throughput screening (HTS) is an important tool in modern drug discovery processes. Many recent, successful drugs can be traced back to HTS [1]. This platform has proliferated from pharmaceutical industry to national labs (e.g. NIH Molecular Libraries Screening Centers Network), and to academic institutions. Besides throughput improvements from thousand molecules in early times to multimillion molecules now, it has been adapted to increasingly sophisticated biological assays such as high content imaging. The vast amount of biological data from these screens presents a significant challenge for identifying interesting molecules in various biological processes. Due to the intrinsic noise of HTS and complex biological processes in most assays, HTS results need careful analysis to identify reliable hit molecules. Various data normalization and analysis algorithms have been developed by different groups over the years. In this chapter, we briefly describe some common issues encountered in HTS and related analysis.

Purchase Chapter  Book Details

Advertisement


Webmaster Contact: info@benthamscience.net Copyright © 2019 Bentham Science