Young Perspectives for Old Diseases


Glaucia Noeli Maroso Hajj

DOI: 10.2174/97816080599281150101
eISBN: 978-1-60805-992-8, 2015
ISBN: 978-1-68108-003-1

Indexed in: EBSCO.

In this book, a great team of young neuroscientists describes the current understanding of common and rare neurodegenerative diseases,...[view complete introduction]
US $
Open Access
(Free to download)
Click here!
Order Printed Copy

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology
Download Flyer

Calcium in Homeostasis and Neurodegeneration

- Pp. 85-101 (17)

Flavio H. Beraldo and Ashbell Roy


All brain functions are controlled by specific synapses where the release of neurotransmitters triggers a number of signaling cascades in postsynaptic neurons. One of the most important and common events is a transient and very fast intracellular Ca<sup>2+</sup> increase. Intracellular Ca<sup>2+</sup> increase is fundamental for modulation of gene expression, neuronal survival and plasticity. In this chapter we will discuss the importance of Ca<sup>2+</sup> in cells as well as the regulation of physiological functions in various organisms. Additionally, we will consider mechanisms used by the cells for Ca<sup>2+</sup> homeostasis and for increasing intracellular Ca<sup>2+</sup> concentration. Finally, the role of Ca<sup>2+</sup> in neurodegenerative diseases such as Alzheimer’s disease (AD), Amyotrophic lateral sclerosis (ALS), Parkinson disease (PD), Huntington disease (HD) among others will be discussed in this chapter.

Download Free  Book Details


Webmaster Contact: Copyright © 2019 Bentham Science