Inositol & its Phosphates: Basic Science to Practical Applications

by

A.K.M. Shamsuddin, Guang-Yu Yang

eISBN: 978-1-68108-007-9, 2015
ISBN: 978-1-68108-008-6



Indexed in: EBSCO.

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functio...[view complete introduction]
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Inositol Compounds: Natural Sources and Chemistry

- Pp. 3-15 (13)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Considerable evidence has accumulated indicating a significant role of dietary inositol and its phosphates, and phospholipid derivatives in human health. In a typical American diet, the amount of myo-inositol per 2500 kcal diet is approximately 900 mg, and most of the inositol compounds are phospholipid derivatives. Virtually all of the ingested myo-inositol (99.8%) is absorbed from the human gastrointestinal tract. In general a normal circulating fasting plasma myo-inositol concentration is approximately 0.03 mM and this material turns over with a half-life of 22 minutes. Contrary to the misconception held by some, inositol hexaphosphate (InsP<sub>6</sub>) likewise is also rapidly absorbed (79 ± 10%) and distributed widely throughout the body. While there are interspecies variations, in general they all point to rather rapid absorption. Following an InsP<sub>6</sub>-poor diet, the basal plasma value in humans is 0.07 ± 0.01 mg.L<sup>-1</sup> that rises to 0.26 ± 0.03 mg.L<sup>-1</sup> after ingestion of InsP<sub>6</sub>-normal diet.

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