Chapter 6

Experimental Cancer Prevention by InsP₆ & Inositol

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Myo-inositol and InsP<sub>6</sub> have independent anticancer action against divergent types of malignancies in a consistent and reproducible manner. The anti-cancer action is dose-dependent and inositol acts synergistically with InsP<sub>6</sub> to enhance the anticancer action of the latter. Since inositol and InsP<sub>6</sub> are common constituents of cereals and legumes, comparative study of high bran diet with equivalent amount of InsP<sub>6</sub> showed that while the ‘high fiber’ diet failed to reduce the incidence of experimental cancer, InsP<sub>6</sub> alone at equivalent dose significantly inhibited mammary cancer formation. Combined with the other studies, these data strongly suggest that supplementation with pure inositol + InsP<sub>6</sub> may be better than gobbling a large amount of fiber.

Total Pages: 67-82 (16)

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