Experimental Cancer Regression by InsP<sub>6</sub> & Inositol
- Pp. 83-106 (24)A.K.M. Shamsuddin and Guang-Yu Yang
Towards the eventual goal of translating the cancer inhibitory effect of inositol & InsP<sub>6</sub> seen in experimental animals in vivo to cancer prevention and therapy in humans, studies of human cancer cells lines were performed in vitro; and human cancer cells xenotransplanted in nude mice were used to test the therapeutic potential. A consistent and reproducible broad-spectrum anticancer action of InsP<sub>6</sub> ± inositol was observed in various models; in human breast cancer model InsP<sub>6</sub> showed synergism with standard chemotherapeutic agents Adriamycin or Tamoxifen. Suppression of cancer growth was seen in xenotransplanted rhabdomyosarcoma model and regression of preexisting cancer was seen in hepatoma model. InsP<sub>6</sub> ± inositol also inhibited various steps in cancer metastasis, inositol potentiated the action. These findings are compelling reasons for application of InsP<sub>6</sub>+inositol for human cancer control.