Inositol & its Phosphates: Basic Science to Practical Applications

by

A.K.M. Shamsuddin, Guang-Yu Yang

eISBN: 978-1-68108-007-9, 2015
ISBN: 978-1-68108-008-6



Indexed in: EBSCO.

Inositol and its phosphates are ubiquitous across most life forms, wherein they play important roles in cellular integrity and functio...[view complete introduction]
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Experimental Cancer Regression by InsP<sub>6</sub> & Inositol

- Pp. 83-106 (24)

A.K.M. Shamsuddin and Guang-Yu Yang

Abstract

Towards the eventual goal of translating the cancer inhibitory effect of inositol &amp; InsP&lt;sub&gt;6&lt;/sub&gt; seen in experimental animals in vivo to cancer prevention and therapy in humans, studies of human cancer cells lines were performed in vitro; and human cancer cells xenotransplanted in nude mice were used to test the therapeutic potential. A consistent and reproducible broad-spectrum anticancer action of InsP&lt;sub&gt;6&lt;/sub&gt; ± inositol was observed in various models; in human breast cancer model InsP&lt;sub&gt;6&lt;/sub&gt; showed synergism with standard chemotherapeutic agents Adriamycin or Tamoxifen. Suppression of cancer growth was seen in xenotransplanted rhabdomyosarcoma model and regression of preexisting cancer was seen in hepatoma model. InsP&lt;sub&gt;6&lt;/sub&gt; ± inositol also inhibited various steps in cancer metastasis, inositol potentiated the action. These findings are compelling reasons for application of InsP&lt;sub&gt;6&lt;/sub&gt;+inositol for human cancer control.

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