Common Pathogenic Mechanisms between Down Syndrome and Alzheimer's Disease: Steps toward Therapy

Book Series: Recent Advances in Alzheimer Research

Volume 1


Ahmad Salehi, Michael Rafii, Cristy Phillips

DOI: 10.2174/97816810813801150101
eISBN: 978-1-68108-138-0, 2015
ISBN: 978-1-68108-139-7
ISSN: 2452-2554 (Print)
ISSN: 2452-2562 (Online)

Indexed in: Scopus, EBSCO.

Down syndrome is a chromosomal disorder affecting more than 5.8 million individuals worldwide. Down syndrome can be viewed as a comple...[view complete introduction]
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Neuropathological Phenotype in Alzheimer’s Disease and Down Syndrome: Chemical Nature and Anatomical Localization

- Pp. 151-172 (22)

Laura J. Pulford, Sarah Müller, Frances K. Wiseman and Amy M. Pooler


Alzheimer’s disease (AD) is characterized by progressive pathological changes in the brain, including accumulation of protein aggregates such as amyloid plaques and neurofibrillary tangles (NFTs). Deposition of these proteins leads to widespread neuronal loss and subsequent cognitive decline. AD-associated pathology also develops in individuals with Down syndrome (DS) and is generally found to precede onset of dementia symptoms. In this chapter, we discuss progressive development of AD pathology, including plaques, NFTs, synaptic dysfunction, neuronal loss, and brain atrophy. Furthermore, we examine similarities and differences in these pathologies between AD and AD/DS. Finally, we review several genetic factors that may contribute to the development of AD.

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