Depression: A Silent Culprit in Health and Disease


Puneetpal Singh, Sarabjit Mastana

DOI: 10.2174/97816810814581150101
eISBN: 978-1-68108-145-8, 2015
ISBN: 978-1-68108-146-5

Depression is considered as a complex problem with potentially serious economic consequences for affected individuals as well as publi...[view complete introduction]
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Diffusion Tensor Imaging Techniques: Insights into Alterations of White Matter Underlying Major Depression and Suicidal Behavior

- Pp. 83-127 (45)

Gianluca Serafini, Matteo Respino, Martino Belvederi Murri and Mario Amore


Based on diffusion tensor imaging (DTI) studies, brain white matter (WM) abnormalities have been recently suggested to play a critical role in the pathophysiology of major depressive disorder (MDD) and suicidal behavior. DTI studies reported the presence of altered WM integrity both in subjects with MDD and suicidal behavior. Microstructural WM abnormalities located in neural circuits critically involved in emotional processes and mood regulation may result in enhanced vulnerability to psychiatric morbidity contributing to functional impairments. However, the role and significance of WM alterations as well as their possible implications in patients with major affective disorders and suicidal behavior are still poorly understood. The present chapter aims to comprehensively review the current literature about the association between microstructural WM alterations as assessed by DTI techniques, MDD and suicide behavior.

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