Advances in Organic Synthesis

Volume 7



DOI: 10.2174/97816810815711170701
eISBN: 978-1-68108-157-1, 2017
ISBN: 978-1-68108-158-8
ISSN: 1574-0870 (Print)
ISSN: 2212-408X (Online)

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challen...[view complete introduction]
US $
Buy Personal eBook
Order Library eBook
Order Printed Copy
Order PDF + Printed Copy (Special Offer)

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology

Bioorthogonal Coupling Strategies Used in Pretargeted Nuclear Imaging and Radiotherapy

- Pp. 174-198 (25)

Justin J. Bailey, Carmen Wängler, Björn Wängler and Ralf Schirrmacher


Bioorthogonal coupling reactions are a powerful tool to create protein conjugates within living systems without interfering with the native biochemical environment. This reaction class has been increasingly utilized over the past few years in the development of new radiopharmaceuticals for medical imaging and radiotherapy. Pretargeting strategies have particularly benefited, where tissue-specific antibodies are first allowed to localize to their target site before a radiolabeled molecule is administered that can covalently bond with the antibody. These radionuclide delivery systems can enhance therapeutic efficacy, reducing radiation exposure and increasing image quality. Current applications of bioorthogonal coupling reactions in pretargeted molecular imaging and radioimmunotherapy will be reviewed.

Purchase Chapter  Book Details


Webmaster Contact: Copyright © 2018 Bentham Science