Novel combined treatments are based on the use of drugs, typically natural active or intended for other uses combined with the classical anti-cancer drug. These compounds promote synergistic effects even more enhanced when drug delivery is achieved by nanocarriers. Nanotechnologies provide a site-specific delivery at the tumor site, resulting from receptor-mediated endocytosis and prolonged circulation time. Nanocarriers also increase drug bioavailability and biocompatibility contributing to a drug increase inside the tumor and determining a minor toxicity and a better efficacy.
This chapter reports recent findings about novel anticancer combined treatments and about the latest drug delivery systems based on the use of nanocarriers.
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