Natural Products in Clinical Trials

Volume 1

by

Prof. Atta-ur-Rahman, FRS, Dr. Shazia Anjum, Dr. Hesham El-Seedi

DOI: 10.2174/97816810821341180101
eISBN: 978-1-68108-213-4, 2018
ISBN: 978-1-68108-214-1
ISSN: 2468-0699 (Print)
ISSN: 2468-0702 (Online)



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Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed...[view complete introduction]
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Table of Contents

Preface

- Pp. i
Atta-ur- Rahman, Shazia Anjum and Hesham El-Seedi
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List of Contributors

- Pp. ii-iii (2)
Atta-ur- Rahman, Shazia Anjum and Hesham El-Seedi
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Clinical Trials for Deriving Bioactive Compounds from Marine Invertebrates

- Pp. 1-30 (30)
Ana R. Gomes, Ana C. Freitas, Armando C. Duarte and Teresa A.P. Rocha-Santos
View Abstract Purchase Chapter

Natural Product Derived Drugs for Immunological and Inflammatory Diseases

- Pp. 31-78 (48)
Narayana Subbiah Hari Narayana Moorthy, Vijayakumari Pratheepa and Elangovan Manivannan
View Abstract Purchase Chapter

Clinical Trials of Curcumin, Camptothecin, Astaxanthin and Biochanin

- Pp. 79-113 (35)
Parasuraman Aiya Subramani, Vinnie Cheeran, Ganesh Munuswamy- Ramanujam and Venkata Ramireddy Narala
View Abstract Purchase Chapter

Antibacterial and Antifungal Drugs from Natural Source: A Review of Clinical Development

- Pp. 114-164 (51)
Shital S. Chavan, Manoj G. Damale, Devanand B. Shinde and Jaiprakash N. Sangshetti
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Anti-HIV Drug Discovery Struggle: From Natural Products to Drug Prototypes

- Pp. 165-232 (68)
Mehtab Parveen, Ali Mohammed Malla, Faheem Ahmad and Shaista Azaz
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Subject Index

- Pp. 233-241 (9)
Atta-ur- Rahman, Shazia Anjum and Hesham El-Seedi
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Preface

Natural products continue to play a key role in drug development. A recent analysis of the drug market in the developed world revealed that 40% of total clinically approved drugs were either unmodified natural products or their semi-synthetic derivatives. This new series of e-books focuses on exciting new bioactive natural products that have huge potential as drugs.

Gomes et al. in chapter 1 review the wide range of natural products derived from marine invertebrates that stand out as an important class of natural products with therapeutic potential, some of which are undergoing clinical studies. Moorthy et al. discuss those natural products that are under clinical trials for immunological and inflammatory diseases in chapter 2. Subramani et al. in chapter 3 discuss the clinical trials of curcumin, camptothecin, astaxanthin, and biochanin for various diseases ranging from inflammation to infection. The chapter also deals with lead optimization, formulations and improved delivery systems of these natural products.

Currently, there is a substantial decline in new drug development for anti-microbial activities, as many microbes are developing resistance and becoming superbugs. Sangshetti et al. in chapter 4 review new antibacterial and antifungal drugs under clinical trials that are mainly derived from natural sources. Numerous natural product based anti-HIV drugs, such as Robustaflavone, Chamaeflavone A, Longipedunins A, Binankadsurin A, Schisanlactone A, Anibamine, Altertoxine, Betulinic acid, Baicalin, and Hinokiflavone are undergoing clinical trials. These are reviewed in the 5th chapter by Parveen et al.

We hope that the readers will enjoy the comprehensive and explicit reviews written by eminent authorities in the field. We are also grateful to the editorial staff of Bentham Science Publishers, particularly Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their continued support.


Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan

Hesham El-Seedi
Division of Pharmacognosy
Department of Medicinal Chemistry, Uppsala University
Biomedical Centre, Box 574
SE-75123 Uppsala
Sweden

List of Contributors

Editor(s):
Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


Dr. Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan


Dr. Hesham El-Seedi
Division of Pharmacognosy
Department of Medicinal Chemistry, Uppsala University
Biomedical Centre, Box 574
SE-75123 Uppsala
Sweden




Contributor(s):
Ana R. Gomes
Department of Chemistry
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal


Ana C. Freitas
Department of Chemistry
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal
/
CESAM
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal
/
ISEIT/Viseu
Instituto Piaget, Estrada do Alto do Gaio, Galifonge
3515-776 Lordosa, Viseu
Portugal


Armando C. Duarte
Department of Chemistry
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal
/
CESAM
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal


Ali Mohammed Malla
Division of Natural Products
Department of Chemistry, Aligarh Muslim University
Aligarh, U.P
India


Devanand B. Shinde
Shivaji University
Vidyanagar Kolhapur (MS)
India


Elangovan Manivannan
School of Pharmacy
Devi Ahilya Vishwavidyalaya
Khandwa Road, Indore-452017
India


Faheem Ahmad
Division of Natural Products
Department of Chemistry
Aligarh Muslim University, Aligarh, U.P
India


Ganesh Munuswamy-Ramanujam
Interdisciplinary Institute of Indian System of Medicine
SRM University
Kattankulathur
India


Jaiprakash N. Sangshetti
Y. B. Chavan College of Pharmacy
Dr. Rafiq zakaria campus
Aurangabad (MS)
India


Mehtab Parveen
Division of Natural Products
Department of Chemistry
Aligarh Muslim University, Aligarh, U.P
India


Manoj G. Damale
Shreeyash Institute of Pharmaceutical Education and Research
Aurangabad (MS)
India


Narayana Subbiah Hari Narayana Moorthy
Departamento de QuĂ­mica e BioquĂ­mica
Faculdade de CiĂȘncias, Universidade do Porto, s/n
Rua do Campo Alegre, 4169-007 Porto
Portugal
/
Department of Pharmacy
Indira Gandhi National Tribal University
Amarkantak-484887, Madhya Pradesh
India


Parasuraman Aiya Subramani
Centre for Fish Immunology
Vels Institute for Science, Technology and Advanced Studies, Vels University
Pallavaram, Chennai
India


Shaista Azaz
Division of Natural Products
Department of Chemistry
Aligarh Muslim University, Aligarh, U.P
India


Shital S. Chavan
Government College of Pharmacy
Aurangabad (MS)
India


Teresa A.P. Rocha-Santos
Department of Chemistry
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal
/
CESAM
University of Aveiro, Campus de Santiago
3810-193 Aveiro
Portugal


Vijayakumari Pratheepa
CIIMAR
289, Rua dos Bragas
4050-123 Porto
Portugal


Vinnie Cheeran
Interdisciplinary Institute of Indian System of Medicine
SRM University
Kattankulathur
India


Venkata Ramireddy Narala
Department of Zoology
Yogi Vemana University
Kadapa
India




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