Frontiers in Clinical Drug Research – Diabetes and Obesity

Volume 3

by

Atta-ur-Rahman

DOI: 10.2174/97816810824791160301
eISBN: 978-1-68108-247-9, 2016
ISBN: 978-1-68108-248-6
ISSN: 2467-9607 (Print)
ISSN: 2352-3220 (Online)



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Indexed in: EBSCO.

Frontiers in Clinical Drug Research – Diabetes and Obesity is an eBook series that brings updated reviews to readers ...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta-ur-Rahman

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List of Contributors

- Pp. ii

Atta-ur-Rahman

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Exendin-4 and Its Derivatives for Diabetes and Obesity: Old Story and New Hope

- Pp. 3-58 (56)

Yong Zhang, Lili Cui, Yan Chen and Wei Kong

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The Growth Hormone/Insulin-like Growth Factor System in the Management of Diabetes and Obesity

- Pp. 59-80 (22)

Moira S. Lewitt

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Insulin, Cardiovascular Function and Long-Term Diabetic Complications

- Pp. 81-113 (33)

Niels Juel Christensen

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Pharmacological Relevance of Novel Biomarkers Associated with Diabetes-mellitus Related Infertility

- Pp. 114-194 (81)

Luis Rato, Marco G. Alves, Branca M. Silva and Pedro F. Oliveira

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Obesity and Type 2 Diabetes Mellitus: Adipocytokines as Markers of Insulin Resistance

- Pp. 195-238 (44)

Katarzyna Zorena

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Subject Index

- Pp. 239-248 (10)

Atta-ur-Rahman

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Preface

Frontiers in Clinical Drug Research – Diabetes and Obesity Volume 3 comprises five comprehensive chapters on novel approaches to combat diabetes and obesity. In Chapter 1, Zhang et al. review the research on Extendin-4, a short peptide derived from lizard saliva, which has been used to treat diabetes and obesity. Insulin-like growth factor and growth hormone are two biochemical agents that play a role in diabetes and obesity. In Chapter 2, Moira S. Lewitt reviews the role of these two hormones in the management of diabetes and obesity.

Patients with long term diabetes suffer from heart problems and other organs are also affected. These problems have been attributed to physiological conditions brought about by the long term effects of insulin resistance on the body which result in hyperglycemic conditions and the presence of reactive oxygen species in mitochondria. In Chapter 3, Niels Juel Christensen presents a comprehensive review on insulin’s effects on capillary permeability in muscle endothelial cells and in podocytes in the kidney.

In Chapter 4, Oliveira et al. present an interesting review on diabetes induced male infertility and pharmaceutical research being conducted to address it. The authors cover the physiology of male infertility, the epigenetics of diabetes induced changes to male gametes and the potential drug targets for treating this condition.

In Chapter 5, Katarzyna Zorena discusses the role of adipocytokines in type 2 diabetes mellitus. The author points out that monitoring concentrations of adipocytokines in the blood can be beneficial for detecting insulin resistance which leads to diabetes. Understanding adipocytokines biochemistry could be the key to prevent the early onset of type 2 diabetes mellitus.

I am very thankful to all the authors for their outstanding contributions. I would also like to appreciate the efforts of the dedicated team of Bentham Science Publishers, especially Dr. Faryal Sami (Assistant Manager Publications), Mr. Shehzad Naqvi (Senior Manager Publications) and Mr. Mahmood Alam (Director Publications).

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman
Kings College University of Cambridge
Cambridge
UK




Contributor(s):
Branca M. Silva
Health Sciences Research Centre (CICS–UBI)
University of Beira Interior, Rua Marquês d’Ávila e Bolama 6200-001 Covilhã
Portugal


Katarzyna Zorena
Department of Immunobiology and Environment Microbiology
Medical University of Gdańsk, Gdańsk
Dębinki 7
Poland


Lili Cui
Pharmaceutical Biophysics Group, Institute of Pharmaceutical Science
King's College London, 150 Stamford Street
London SE1 9NH
United Kingdom


Luís Rato
Health Sciences Research Centre (CICS–UBI)
University of Beira Interior, Rua Marquês d’Ávila e Bolama 6200-001 Covilhã
Portugal


Marco G. Alves
Health Sciences Research Centre (CICS–UBI)
University of Beira Interior, Rua Marquês d’Ávila e Bolama 6200-001 Covilhã
Portugal


Moira S. Lewitt
School of Health Nursing and Midwifery
University of the West of Scotland
Paisley PA1 2BE
Scotland


Niels Juel Christensen
Herlev University Hospital
Denmark


Pedro F. Oliveira
Department of Microscopy, Laboratory of Cell Biology
Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto
Porto
Portugal.
/
Unit for Multidisciplinary Research in Biomedicine (UMIB)
Institute of Biomedical Sciences Abel Salazar (ICBAS), University of Porto
Porto
Portugal.
/
i3S - Instituto de Inovação e Investigação em Saúde
University of Porto
Porto
Portugal


Wei Kong
National Engineering Laboratory for AIDS Vaccine
School of Life Sciences, Jilin University
Changchun 130012
China.
/
Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences
Jilin University
Changchun 130012
China


Yan Chen
National Engineering Laboratory for AIDS Vaccine
School of Life Sciences, Jilin University
Changchun 130012
China.
/
Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences
Jilin University
Changchun 130012
China


Yong Zhang
National Engineering Laboratory for AIDS Vaccine
School of Life Sciences, Jilin University
Changchun 130012
China.
/
Key Laboratory for Molecular Enzymology and Engineering, the Ministry of Education, School of Life Sciences
Jilin University
Changchun 130012
China




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