Frontiers in Clinical Drug Research – Anti Allergy Agents

Volume 3

by

Atta-ur-Rahman

DOI: 10.2174/97816810833771180301
eISBN: 978-1-68108-337-7, 2018
ISBN: 978-1-68108-338-4
ISSN: 2452-3194 (Print)
ISSN: 2214-6938 (Online)



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Table of Contents

Preface

- Pp. 1
Atta-ur- Rahman
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List of Contributors

- Pp. ii
Atta-ur- Rahman
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Developing the Perfect Antihistamine for Use in Allergic Conditions: A Voyage in H1 Selectivity

- Pp. 1-95 (95)
Diana R. Cundell and Kathryn E. Mickle
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Therapeutics in Chronic Spontaneous Urticaria

- Pp. 96-115 (20)
Alexei Gonzalez-Estrada and James Fernandez
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Research and Development for Anti-Asthmatic Agents with a Focus on Phenotype Changing by Ca2+ Signaling in Airway Smooth Muscle Cells

- Pp. 116-181 (66)
Hiroaki Kume
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Effects of Allergic Rhinitis on Communication Skills

- Pp. 182-193 (12)
Can Cemal Cingi, Erkan Yuksel and Nuray Bayar Muluk
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Endosomal Toll-like Receptors: Rheostats of Inflammation and Diseases

- Pp. 194-236 (43)
Chhedi Lal Gupta, Rohit Kumar Tiwari, Neelam Pathak and Preeti Bajpai
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Subject Index

- Pp. 237-247 (11)
Atta-ur- Rahman
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Preface

Frontiers in Clinical Drug Research - Anti Allergy Agents (Volume 3) comprises five comprehensive chapters on various treatment strategies for allergic conditions. In chapter 1, Cundell and Mickle focus on the existing different generations of drugs and the development of more potent anti-histamines. In the second chapter, Gonzalez-Estrada and Fernandez discuss the common drugs used for managing Chronic Spontaneous Urticaria, their side effects, and monitoring parameters. Both Ca2+ dynamics and Ca2+ sensitization are responsible for alterations in contractility in airway smooth muscle cells that lead to conditions of asthma and chronic obstructive pulmonary disease (COPD). Hiroaki Kume in chapter 3 of this book explain that the Ca2+ dynamics and Ca2+ sensitization may be the therapeutic approaches for treating asthma and COPD, and research in these areas may provide novel strategies for the development of bronchodilators for these diseases that will be effective for both bronchoconstriction and airway inflammation. In the next chapter Cingi et al. review the effects of Allergic Rhinitis on communication skills mainly in three categories: physiological, psychological and behavioral. In the last chapter, Bajpai et al. present the role of Endosomal Toll-like Receptors in inflammation and related diseases. They focus on the structural features of Toll-like Receptors, specific ligands, intracellular signaling and the role of Endosomal TLRs in the aggravation of diseases.

I hope that this volume will be of great interest to the scientific community and will play a vital role in the development of more effective therapeutic agents to combat various pulmonary ailments.

I would like to thank all the authors and the excellent team of Bentham Science Publishers, especially Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their support and hardwork.

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow,
Kings College,
University of Cambridge,
Cambridge,
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Alexei Gonzalez-Estrada
Department of Allergy and Clinical Immunology
Respiratory Institute, Cleveland Clinic Foundation
Cleveland, OH
USA


Can Cemal Cingi
Department of Communication Design and Management, Faculty of Communication Sciences
Anadolu University
Eskişehir
Turkey


Chhedi Lal Gupta
Department of Biosciences
Integral University
Lucknow-226026, UP
India


Diana R. Cundell
Division of Health Professions, College of Science, Health and the Liberal Arts
Philadelphia University
Philadelphia, PA
USA


Erkan Yüksel
Department of Journalism, Faculty of Communication Sciences
Anadolu University
Eskişehir
Turkey


Hiroaki Kume
Faculty of Medicine, Department of Respiratory Medicine and Allergology
Kindai University
377-2 Ohnohigashi, Osakasayama, Osaka 589-8511
Japan
/
Department of Respiratory Medicine
Rinku General Medical Center
2-23 Rinkuohraikita, Izumisano, Osaka 598-8577
Japan


James Fernandez
Department of Allergy and Clinical Immunology
Respiratory Institute, Cleveland Clinic Foundation
Cleveland, OH
USA


Kathryn E. Mickle
Division of Health Professions, College of Science, Health and the Liberal Arts
Philadelphia University
Philadelphia, PA
USA


Neelam Pathak
Department of Biosciences
Integral University
Lucknow-226026, UP
India


Nuray Bayar Muluk
Department of ENT, Faculty of Medicine
Kirikkale University
Kirikkale
Turkey


Preeti Bajpai
Department of Biosciences
Integral University
Lucknow-226026, UP
India


Rohit Kumar Tiwari
Department of Biosciences
Integral University
Lucknow-226026, UP
India




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