Frontiers in Clinical Drug Research-Anti Infectives

Volume 3

by

Atta-ur-Rahman

DOI: 10.2174/97816810836981170301
eISBN: 978-1-68108-369-8, 2017
ISBN: 978-1-68108-370-4
ISSN: 2452-3208 (Print)
ISSN: 2352-3212 (Online)



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Indexed in: EBSCO.

Frontiers in Clinical Drug Research – Anti Infectives is an eBook series that b...[view complete introduction]

Table of Contents

Preface

- Pp. i

Atta -ur-Rahman

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List of Contributors

- Pp. ii

Atta -ur-Rahman

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Modern Approaches to Genome Mining for the Development of New Anti-infectives: In Silico Gene Prediction and Experimental Metabolomics

- Pp. 3-48 (46)

Elena Martinez-Klimova, Sara Centeno-Leija and Sergio Sanchez

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A Novel Complementary Approach Using New Probiotic Product for the Improvement of HIV Therapy

- Pp. 49-121 (73)

Constantin V. Sobol

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Anti-HIV Agents: The Way Forward for the Complete Eradication of the Virus

- Pp. 122-138 (17)

Ali A. Al-Jabri, Elias A. Said, Mohammed S. Al-Balushi and Sidgi S. Hasson

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Essential Oils, Polyphenols and Glycosides: Secondary Plant Metabolites against Human Pathogenic Microbes

- Pp. 139-186 (48)

Ana C. Sampaio, Alfredo Aires, Eliana B. Souto and Amelia M. Silva

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Photosensitizers: An Effective Alternative Approach to Microbial Pathogen

- Pp. 187-218 (32)

Sasirekha Bakthavatchalu and Gahamanyi Noel

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Subject Index

- Pp. 219-227 (9)

Atta -ur-Rahman

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Preface

The third volume of Frontiers in Clinical Drug Research – Anti Infectives comprises five chapters that cover genomic mining for anti-infectives, HIV treatments and photosensitizers for anti-microbial activity.

In the first chapter, Sanchez and colleagues review the research in genomic data mining to predict gene clusters that are responsible for coding for secondary metabolites that exhibit antimicrobial activity. They give information about the tools in metabololomics used for the purpose and also give examples of links established through predictive methods. The authors also provide information about research techniques used in metabolomics adding value to their work for readers.

In the second chapter Sobol discusses recent developments concerning a new probiotic prophylactic for HIV treatment. This probiotic stimulates the growth of microflora that increase the concentration of antibodies in the mucosa, thereby boosting the immune system. Continuing with the theme of HIV/AIDS treatments, Al-Jabri et al., have contributed a review on the status of HIV medications that are geared towards eliminating the virus from the body. This review is a reminder to readers that the hope for finding a cure for AIDS, while difficult, is still alive. Readers will find the list of drugs covered in this review useful for keeping their knowledge updated on current anti-HIV medicines.

In chapter 4, Sampaio et al. provide a review of natural products (essential oils, glycosides, polyphenols and other secondary metabolites) that can be used to treat microbial infections in vivo. In the last chapter, Bakthavatchalu and Noel present an interesting review of the use of photosensitizers for treating bacterial infections. Light based treatments (Antimicrobial Photodynamic Therapy, APDT) are a good way to combat drug resistant pathogens.

I would like to acknowledge the efforts of all the contributors for their outstanding contributions. I am also thankful to the team of Bentham Science Publishers, especially Dr. Faryal Sami and Mr. Shehzad Naqvi led by Mr. Mahmood Alam, Director Bentham Science Publishers for their efforts.

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Alfredo Aires
Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB)
Vila Real
Portugal
/
Department of Agronomy
UTAD, Quinta dos Prados
5001-801 Vila Real
Portugal


Ali A. Al-Jabri
Division of Immunology, Department of Microbiology and Immunology
College of Medicine and Health Sciences
SQU
Oman


Amélia M. Silva
Department of Biology and Environment
University of Trás-os-Montes e Alto Douro (UTAD), Quinta dos Prados
5001-801 Vila Real
Portugal
/
Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB)
Vila Real
Portugal


Ana C. Sampaio
Department of Biology and Environment
University of Trás-os-Montes e Alto Douro (UTAD), Quinta dos Prados
5001-801 Vila Real
Portugal
/
Centre for Research and Technology of Agro-Environmental and Biological Sciences (CITAB)
Vila Real
Portugal


Constantin V. Sobol
Sechenov Institute of Physiology and Biochemistry
Russian Academy of Sciences
Saint-Petersburg
Russia


Elena Martinez-Klimova
Instituto de Investigaciones Biomédicas
Universidad Nacional Autónoma de México
México D.F. 04510
Mexico


Eliana B. Souto
Department of Pharmaceutical Technology, Faculty of Pharmacy
University of Coimbra (FFUC), Pólo das Ciências da Saúde, Azinhaga de Santa Comba
3000-548 Coimbra
Portugal
/
REQUIMTE/LAQV, Group of Pharmaceutical Technology
FFUC
Coimbra
Portugal


Elias A. Said
Division of Immunology, Department of Microbiology and Immunology
College of Medicine and Health Sciences
SQU
Oman


Gahamanyi Noel
Faculty of Science and Technology, Department of Biomedical Laboratory Sciences
Catholic University of Rwanda
P.O.Box 49 Butare/Huye
Rwanda


Mohammed S. Al-Balushi
Division of Immunology, Department of Microbiology and Immunology
College of Medicine and Health Sciences
SQU
Oman


Sara Centeno-Leija
Catedrático CONACYT, Laboratorio de Bioingeniería
Universidad de Colima, Km. 9 Carretera Coquimatlán-Colima, C.P. 28400 Coquimatlán
Colima
México


Sasirekha Bakthavatchalu
Department of Microbiology
Acharya Bangalore B School, Off Magadi road
Bangalore-560 091
India


Sergio Sánchez
Instituto de Investigaciones Biomédicas
Universidad Nacional Autónoma de México
México D.F. 04510
Mexico


Sidgi S. Hasson
Division of Immunology, Department of Microbiology and Immunology
College of Medicine and Health Sciences
SQU
Oman




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