Pain: Causes, Concerns and Consequences

by

Puneetpal Singh, Monica Singh

DOI: 10.2174/97816810837111160101
eISBN: 978-1-68108-371-1, 2016
ISBN: 978-1-68108-372-8



Indexed in: EBSCO.

Pain is a significant medical problem, as it is a factor in many diseases and debilitating conditions. The processing of pain in the b...[view complete introduction]
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Functional Brain Circuitry in Central Post-stroke Pain

- Pp. 17-39 (23)

Andrew Chih Wei Huang, Hsiang-Chin Lu and Bai Chuang Shyu

Abstract

Central post-stroke pain (CPSP) results from lesions or dysfunction of the spinothalamocortical pathway. Pathophysiological mechanism of CPSP may include contralateral somatosensory cortex or bilateral mid- and posterior insula, anterior insula, posterior cingulate cortex and spinothalamocortical pathway. Our [14C] iodoantipyrine data from animal model of CPSP indicated that significantly higher activation occurs in the medial prefrontal cortex (mPFC), anterior cingulate cortex, thalamus, hypothalamus, amygdala and periaqueductal gray (PAG). We propose a neural correlation hypothesis of CPSP, in which the mPFC-amygdala pathway, hypothalamus and PAG interact with each other and the spinothalamocortical pathway, resulting in the manifestation of CPSP symptoms. These symptoms can include depression, anxiety, motor disturbances and cognitive dysfunction in thalamic stroke patients, in addition to CPSP. Alterations in different brain activation and circuitry connections in CPSP may help in understanding the pathophysiological mechanisms underlying multiple aspects of CPSP symptoms. Such novel ideas may be applied to develop pharmacological and non-pharmacological interventions for CPSP.

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