New Concepts in Stroke Diagnosis and Therapy

Book Series: Current Developments in Stroke

Volume 1

by

Alberto Radaelli, Giuseppe Mancia, Carlo Ferrarese, Simone Beretta

DOI: 10.2174/97816810842131170101
eISBN: 978-1-68108-421-3, 2017
ISBN: 978-1-68108-422-0
ISSN: 2542-5110 (Print)
ISSN: 2542-5129 (Online)



Indexed in: EBSCO.

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such...[view complete introduction]

Stroke and Hypertension

- Pp. 3-25 (23)

Cristina Sierra and Antonio Coca

Abstract

Stroke, the third most-common cause of mortality after cancer and heart disease in developed countries, is one of the most common causes of cognitive impairment and vascular dementia. Stroke pathogenesis and its consequences are not completely elucidated, with various factors and biological mechanisms probably having a role. After age, hypertension is the leading modifiable cardiovascular risk factor for ischaemic/haemorrhagic stroke, small vessel disease predisposing to lacunar infarction, cerebral white matter lesions (cWML), and cerebral microbleeds. Primary stroke prevention, involving hypertension therapy and blood pressure (BP) control is now standard. At the same time, elevated post-stroke BP levels increase the risk of recurrent stroke, with recent trials suggesting that BP reduction with combinations of hypertension therapy reduces stroke recurrence. This chapter reviews the evidence on hypertension as a stroke risk factor and the part played by hypertension therapy in first/recurrent stroke prevention.

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