New Concepts in Stroke Diagnosis and Therapy

Book Series: Current Developments in Stroke

Volume 1


Alberto Radaelli, Giuseppe Mancia, Carlo Ferrarese, Simone Beretta

DOI: 10.2174/97816810842131170101
eISBN: 978-1-68108-421-3, 2017
ISBN: 978-1-68108-422-0
ISSN: 2542-5110 (Print)
ISSN: 2542-5129 (Online)

Indexed in: EBSCO.

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such...[view complete introduction]

Autonomic Nervous System Dysfunction and Risk of Stroke

- Pp. 26-56 (31)

Alberto Radaelli, Paolo Castiglioni and Giuseppe Mancia


Cerebrovascular disease is predicted to remain the second leading cause of mortality reaching almost eight million annual deaths by 2030. Cerebral arteries are innervated and are therefore potential targets for autonomic nervous system dysfunction. In particular, a dynamic baroreflex mediated sympathetic modulation of cerebral blood flow has been demonstrated, confirming the role that the autonomic nervous system exerts on cerebral flow regulation. Moreover, it has been shown that the vagus nerve may influence neuro-inflammation therefore producing an inflammatory mediated vascular damage in case of dysfunction. Dynamic interactions between cerebral blood flow and the autonomic nervous system activity are therefore important and can be analyzed by studying the rhythms that characterize both cerebral blood flow, blood pressure and heart rate. With this regard, variability analysis performed together with techniques that investigate cerebral blood flow distribution and together with functional evaluation of the brain could provide new insight on the role played by the autonomic nervous system in the progression of cerebral vascular disease.

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2nd Annual MENA Physical Medicine & Rehabilitation Congress

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