New Concepts in Stroke Diagnosis and Therapy

Book Series: Current Developments in Stroke

Volume 1

by

Alberto Radaelli, Giuseppe Mancia, Carlo Ferrarese, Simone Beretta

DOI: 10.2174/97816810842131170101
eISBN: 978-1-68108-421-3, 2017
ISBN: 978-1-68108-422-0
ISSN: 2542-5110 (Print)
ISSN: 2542-5129 (Online)



Indexed in: EBSCO.

This volume presents a summary of recent research and debates on old and new aspects in stroke medicine. The volume covers topics such...[view complete introduction]

Pharmacological and Endovascular Recanalization Therapy

- Pp. 250-269 (20)

E.C. Agostoni and M. Longoni

Abstract

The major aim of acute stroke treatment is to save the hypoperfused cerebral parenchyma in order to minimize residual disability. Early recanalization of occluded arteries with thrombolytic therapy is the most efficient procedure for protecting the brain parenchyma which is not yet infarcted.

Intravenous administration of Alteplase (recombinant tissue-type plasminogen activator – rtPA) has proven to be effective in reducing disability at 90 and 180 days after stroke in patients treated within 4.5 hours from symptoms onset.

Recently, striking results have been provided by the endovascular treatment, unless in a selected population. The use of the stent-retrievers or direct thrombus aspiration is now a good option for acute stroke treatment giving the opportunity of an effective multimodal therapeutic approach.



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