The Search for Antidepressants - An Integrative View of Drug Discovery

Book Series: Frontiers in Drug Discovery

Volume 2


Andre F. Carvalho, Gislaine Zilli Reus, João Luciano de Quevedo

DOI: 10.2174/97816810847321170201
eISBN: 978-1-68108-473-2, 2017
ISBN: 978-1-68108-474-9
ISSN: 2542-7350 (Print)
ISSN: 2214-6210 (Online)

Major depressive disorder (MDD) is a prevalent, chronic, and recurring mental disorder. This disorder is a leading source of disabi...[view complete introduction]
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Repurposed Drugs: A Shortcut to the Discovery of Novel Antidepressants?

- Pp. 135-176 (42)

Young Sup Woo, Yena Lee and Roger S. McIntyre


Drug repurposing aims to find new therapeutic indications for existing drugs in the market. Because the process of discovering a new pharmacological compound with desired clinical effectiveness is challenging, drug repurposing is being increasingly utilized in many areas. To address the unmet needs and limitations of treating depressive disorders with available treatments, many pharmacological agents are being investigated for antidepressant efficacy. For example, there have been some promising results with repurposing agents targeting acetylcholinergic and glutamatergic neurotransmission, as well as modulating immune system. Furthermore, anti-glucocorticoid agents also suggested to have possible antidepressant activity. In this chapter, we summarize the results from studies on the repurposing for treating depression of various agents, and search for perspectives on treatment strategies for depression beyond approved antidepressants.

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