Cancer Preventive and Therapeutic Compounds: Gift From Mother Nature


by

Sahdeo Prasad, Amit Kumar Tyagi

DOI: 10.2174/97816810849161170101
eISBN: 978-1-68108-491-6, 2017
ISBN: 978-1-68108-492-3



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Indexed in: EBSCO.

Cancer is a major cause of deaths all around the globe. Although numerous anticancer drugs are available, most of them are expensive a...[view complete introduction]

Table of Contents

Foreword

- Pp. i-ii (2)

Anushree Malik

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Preface

- Pp. iii

Sahdeo Prasad and Amit K Tyagi

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List of Contributors

- Pp. iv-v (2)

Sahdeo Prasad and Amit K Tyagi

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Dietary Agents: Effective and Safe Natural Assets Against Cancer

- Pp. 3-19 (17)

Sahdeo Prasad and Amit K. Tyagi

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Medicinal Importance of Allicin - A Bioactive Component from Allium Sativum L (Garlic)

- Pp. 20-31 (12)

R. Jayaraj and Roshan Lal

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Boswellic Acids as Potential Cancer Therapeutics

- Pp. 32-63 (32)

Manjeet Kumar, Arvind Kumar, Omkar P. Dhamale and Bhahwal Ali Shah

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Natural Compounds: Cancer Preventive Agents

- Pp. 64-86 (23)

Sandeep K Misra

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African Medicinal Plants: An Untapped Reservoir of Potential Anticancer Agents

- Pp. 87-104 (18)

Conrad V. Simoben and Fidele Ntie-Kang

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Phytochemicals in Therapy of Radiation Induced Damage and Cancer

- Pp. 105-124 (20)

Pankaj Taneja, Mehak Gulzar, Neetu Kumra Taneja, BS Dwarakanath and RP Tripathi

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Marine Natural Products for Cancer Prevention and Therapy: A Mechanistic Overview

- Pp. 125-146 (22)

Shankar Suman, Sanjay Mishra and Yogeshwer Shukla

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Natural Products as a Unique Source of Anti- Cancer Agents

- Pp. 147-181 (35)

Shinjini Singh

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Translation of Natural Products into Clinically Effective Drugs: How Far We Have Gone

- Pp. 182-193 (12)

Ammad Ahmad Farooqi, Ilhan Yaylim, Rukset Attar, Muhammad Zahid Qureshi, Faiza Yasmeen and Sobia Tabassum

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Subject Index

- Pp. 194-201 (8)

Sahdeo Prasad and Amit K Tyagi

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Foreword

Among various chronic diseases, cancer is one of the most dreaded diseases throughout the world. Despite dramatic improvements in surgical and reconstructive techniques, the overall mortality rates for cancer remain relatively unchanged. To date, numerous screening and preventive approaches have been directed towards cancer, which clearly reflect a decrease in the morbidity and mortality associated with cancer. The screening measures include physical exam and history, laboratory tests, imaging and genetic tests on timely basis. However, primary prevention of cancer is more important to keep cancer away from developing. This includes maintaining a healthy lifestyle and avoiding exposure to known cancer-causing substances. Thus cancer risk can be reduced with healthy choices like avoiding tobacco, limiting alcohol use, protecting skin from the sun and avoiding indoor tanning, eating a diet rich in fruits and vegetables, keeping a healthy weight, and being physically active.

Lifestyle plays an important role in the prevention of this disease. By adopting a diet consisting primarily of whole grains, fruits and vegetables with limited amounts of meat, primarily chicken or cold-water fish, and doing daily exercise, several risk factors can be avoided. Various methods are available for the treatment of cancers and the selection will depend on the cost, morbidity, requirement of reliable biopsy specimens, resources available, etc. Thus management of cancer by self-care could be a great potential to improve detection and the treatment of cancer; morbidity and mortality also will decrease as a result. The field has broad and wide applications and with every new development reported in leading peer-reviewed journals across the globe, the opportunities only become wider and the hopes brighter.

The editors Dr. Sahdeo Prasad and Dr. Amit Tyagi have done an excellent job of bringing out timely peer-reviewed chapters under the banner "Cancer Preventive and Therapeutic Compounds: Gift From Mother Nature" with contributors spreading across four different continents. I complement the authors and appreciate their efforts in bringing out this comprehensive compilation. It is quite impressive to note that the editors have tried to capture such a wide and dynamic topic in a series of attractive articles highlighting different forms of cancer prevention and treatment research, both existing and newly emerging technologies in the field, approaches, advantages, thoughts from around the world along with potential future prospects. The simplicity of the language and presentation style is very much appealing and impressive.

It is my great pleasure to pen down/write the foreword for this prestigious, multi-authored book compilation withpeer-reviewed chapters. This book will be a valuable resource for the scientists and students seeking updated and critical information for their experimental plans. It will be very useful for the clinician to develop clinical trials using natural compounds with or without existing therapeutic drugs. Pharmaceutical companies could design new formulations based on the literature available in this new book. Most importantly, normal population and cancer patients can be benefited by knowing the preventive and therapeutic efficacy of natural compounds. They can use these natural compounds in their routine life. This book could be a major breakthrough worldwide for the readers, particularly the cancer patients.

Anushree Malik, PhD
Associate Professor
Applied Microbiology Lab, CRDT
Indian Institute of Technology Delhi, New Delhi
India 110016


Preface

Cancer is one of the leading causes of deaths around the world and it is globally increasing. The highest incidence rates are in the developed countries such as the USA, and the lowest rates are found in developing countries. These differences in incidence rates appear to be attributable to geographical differences in diet and environmental exposure. Although environmental and genetic factors are the major risk factors for cancer, lifestyle also contributes to the development of this disease. Although screening modalities for early detection and therapeutic management of cancer have improved considerably, this disease still needs better treatment modalities. Since long-term use of cytotoxic chemotherapy and radiotherapy can have severe side effects and since tumors can develop resistance to these therapies, agents that can overcome tumor resistance, enhance the therapeutic efficacy of existing drugs and can control multiple signaling pathways are needed to treat cancer.

Although numerous anticancer drugs are available, most of them are expensive and have serious side effects. Thus, the challenging task of finding an alternative cancer treatment measure has become more important than ever to both scientists and physicians. Since natural compounds have been identified and explored for their health benefits for centuries, several nutritional factors have attracted considerable attention as modifiable risk factors in the prevention and treatment of cancer. Natural products are important sources of anti-cancer lead molecules; even many successful anti-cancer drugs approved by FDA are natural products or their derivatives. Still many more are under clinical trials. Based on the current available research, the present book will focus on the chemopreventive and anti-cancer activities of different natural/dietary compounds such as fruits, vegetable, spices, legumes, nuts, grains, and cereals highlighting their potential use against cancer treatment. Since these natural compounds including fruits and vegetables contain a wide variety of phytochemicals, they may have anti-carcinogenic effects. Evidences showed that the phytochemicals present in fruits and vegetables modulate large numbers of cell signaling molecules linked with cancer. The modulation of signaling molecules controls the abnormal growth of cells and ultimately controls the growth of cancer. Also antioxidative and anti-inflammatory properties of natural compounds could hold promise for cancer chemoprevention because oxidative stress and chronic inflammation play important roles in cancer development.

This book is the culmination of the efforts of several researchers, scientists, graduate students and post-doctoral fellows across the world. In this book authors focused on the role of natural compounds in the prevention and therapy of various cancers. The book has enormous scope and will benefit multiple audience including researchers, clinicians, patients, academicians, industrialists, and students. The editors are also thankful to Bentham Publisher and their team members for the opportunity to publish this book. Lastly we thank our family members for their love, support, encouragement and patience during the entire period of this work.

Sahdeo Prasad & Amit K Tyagi
Department of Experimental Therapeutics, Division of Cancer Medicine
The University of Texas M. D. Anderson Cancer Center
Houston, TX 77054, USA

List of Contributors

Editor(s):
Sahdeo Prasad
Department of Experimental Therapeutics
Division of Cancer Medicine
The University of Texas M. D. Anderson Cancer Center
Houston
TX 77054
USA


Amit Kumar Tyagi
Department of Experimental Therapeutics
Division of Cancer Medicine
The University of Texas M. D. Anderson Cancer Center
Houston
TX 77054
USA




Contributor(s):
Amit K. Tyagi
Department of Experimental Therapeutics, Division of Cancer Medicine
The University of Texas M. D. Anderson Cancer Center
Houston
TX 77054
USA


Ammad Ahmad Farooqi
Institute of Biomedical and Genetic Engineering (IBGE)
Islamabad
Pakistan


Arvind Kumar
Natural Product Microbes
CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road
Jammu Tawi
India


B.S. Dwarkanath
Institute of Nuclear Medicine and Allied Science
Street no.
SK Majumdar Marg
New Delhi
India


Bhahwal Ali Shah
Natural Product Microbes
CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road
Jammu Tawi
India


Conrad V. Simoben
Pharmaceutical Chemistry
Martin-Luther Universität Halle-Wittenberg
Wolfgang-Langenbeck-Str. 4
06120 Halle (Saale)
Germany
/
Chemistry Department
University of Buea
South West Region
Cameroon
Central Africa


Faiza Yasmeen
Institute of Blood Transfusion Services
Lahore
Punjab
Pakistan


Fidele Ntie-Kang
Pharmaceutical Chemistry
Martin-Luther Universität Halle-Wittenberg
Wolfgang-Langenbeck-Str. 4
06120 Halle (Saale)
Germany
/
Chemistry Department
University of Buea
South West Region
Cameroon
Central Africa


Ilhan Yaylim
Istanbul University, Department of Molecular Medicine
Institute of Experimental Medicine Istanbul
Istanbul
Turkey


Manjeet Kumar
Natural Product Microbes
CSIR-Indian Institute of Integrative Medicine (CSIR), Canal Road
Jammu Tawi
India


Mehak Gulzar
Department of Biotechnology, School of Engineering and Technology
Sharda University, Knowledge Park-III, Gautam Buddha Nagar
Street no.
Greater Noida
Uttar Pradesh, Pin code-201306
India
/
Nutrametrix Health Solutions
USA


Muhammad Zahid Qureshi
GCU Department of Chemistry
Lahore
Punjab
Pakistan


Neetu Kumra Taneja
National Institute of Food Technology Entrepreneurship and Management
Kundli
Sonipat, Haryana
India


Omkar P. Dhamale
Sanofi Pasteur, 1 Discovery Drive
Swiftwater
Pennsylvania
USA


Pankaj Taneja
Department of Biotechnology, School of Engineering and Technology
Sharda University, Knowledge Park-III, Gautam Buddha Nagar
Greater Noida
Uttar Pradesh, Pin code-201306
India
/
Nutrametrix Health Solutions
USA


R. Jayaraj
Biochemistry Laboratory, Non-Timber Forest Produce Department
Kerala Forest Research Institute, Peechi
Thrissur
Kerala – 680653
India


R.P. Tripathi
Institute of Nuclear Medicine and Allied Science
Street no.
SK Majumdar Marg
New Delhi
India


Roshan Lal
Biochemistry Laboratory, Non-Timber Forest Produce Department
Kerala Forest Research Institute, Peechi
Thrissur
Kerala – 680653
India


Rukset Attar
Yeditepe University Medical School Istanbul
Istanbul
Turkey


Sahdeo Prasad
Department of Experimental Therapeutics, Division of Cancer Medicine
The University of Texas M. D. Anderson Cancer Center
Houston
TX 77054
USA


Sandeep K. Misra
University of Mississippi
Oxford
Mississippi
USA 38677


Sanjay Mishra
Proteomics and Environmental Carcinogenesis Laboratory
CSIR-Indian Institute of Toxicology Research, M.G. Marg
Lucknow
India


Shankar Suman
Proteomics and Environmental Carcinogenesis Laboratory
CSIR-Indian Institute of Toxicology Research, M.G. Marg
Lucknow
India


Shinjini Singh
Cytokine Research Laboratory, Department of Experimental Therapeutics
The University of Texas, M.D. Anderson Cancer Center
Houston
Texas 77054
USA


Sobia Tabassum
Department of Bioinformatics and Biotechnology
International Islamic University
Islamabad
Pakistan


Yogeshwer Shukla
Proteomics and Environmental Carcinogenesis Laboratory
CSIR-Indian Institute of Toxicology Research, M.G. Marg
Lucknow
India




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