New Trends in Biomarkers and Diseases Research: An Overview

by

Juan Antonio Vílchez, María Dolores Albaladejo-Otón

DOI: 10.2174/97816810849541170101
eISBN: 978-1-68108-495-4, 2017
ISBN: 978-1-68108-496-1





Biomarkers are any measurable biochemical characteristics of an organism that reflect a particular physiological state. Biomarkers can...[view complete introduction]
US $
Buy Personal eBook
129
Order Library eBook
516
Order Printed Copy
*183
Order PDF + Printed Copy (Special Offer)
*247

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology

Biomarkers of Bone Turnover: Molecular Approaches and Clinical Relevance

- Pp. 153-188 (36)

Irene de Miguel-Elízaga, Ana Martínez-Ruíz, Natalia Sancho-Rodríguez and Miriam Martínez-Villanueva

Abstract

Osteoporosis, a disease characterized by low bone mass and deterioration of bone microarchitecture, leads to increased fragility and susceptibility to fracture. It is an important public health problem of the elderly and it is expected to rise with an increased life expectancy in the next years. Bone mineral density (BMD) measured by dual-energy X-ray absorptiometry (DXA) is considered as the gold standard of bone status assessment despite the associated limitations. In recent years great progress has been made in the identification and characterization of biomarkers to aid the knowledge of metabolic bone disease and within the last years, a large number of new bone turnover markers (BTM) with increased specificity and sensitivity have been developed. BTM of formation and desorption are released during the process of bone remodeling. Bone biomarkers can be a great tool for the diagnosis of osteoporosis, but their use in clinical practice is limited because there are subjected to various preanalytical and analytical variations. Also, BTM are frequently used to provide valid information about the effectiveness of osteoporosis treatment (antiresorptive or bone formation therapies) although they are not useful alone to estimate bone loss. In this review, conventional and novel BTMs, their use and limitations into clinical practice, available diagnostic methods and current recommendations are discussed.

Purchase Chapter  Book Details

Advertisement

Nobel LaureateFocus Medica

Webmaster Contact: info@benthamscience.org Copyright © 2018 Bentham Science