New Trends in Biomarkers and Diseases Research: An Overview


by

Juan Antonio Vílchez, María Dolores Albaladejo-Otón

DOI: 10.2174/97816810849541170101
eISBN: 978-1-68108-495-4, 2017
ISBN: 978-1-68108-496-1





Biomarkers are any measurable biochemical characteristics of an organism that reflect a particular physiological state. Biomarkers can...[view complete introduction]

Current Trends in Biomarkers of Acute Coronary Syndrome

- Pp. 251-284 (34)

Carmen María Puche-Morenilla, Luis García de Guadiana Romualdo and Juan Antonio Vílchez

Abstract

Evaluation of patients presented to the emergency department with a complaint of chest pain or other signs and/or symptoms suggestive of acute coronary syndrome (ACS) is expensive and time-consuming. Nowadays, cardiac troponins (cardiac troponins I and T) are established as the standard biomarkers for prognostic evaluation and the detection of myocardial lesion of patients with ACS. Several studies have demonstrated that increases in biomarkers upstream from biomarkers of myocardial injury such as acute phase reactants, markers of inflammation, plaque destabilization and rupture biomarkers, cellular adhesion molecules and biomarkers of ischemia may identify patients with higher risk of having a cardiac event. The focus of this review is to provide information on biomarkers, specifically cardiac troponin, interleukin-6 and copeptin, which has become very important to improve the diagnosis of acute coronary syndrome and to predict prognosis following an actual event.

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