Laser Optofluidics in Fighting Multiple Drug Resistance


by

Mihail Lucian Pascu

DOI: 10.2174/97816810849851170101
eISBN: 978-1-68108-498-5, 2017
ISBN: 978-1-68108-499-2



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This monograph is a collection of reviews that presents results obtained from new and somewhat unconventional methods used to fight mu...[view complete introduction]

Table of Contents

Preface

- Pp. i-ii (2)

Mihail Lucian Pascu

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List of Contributors

- Pp. iii-iv (2)

Mihail Lucian Pascu

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Introduction

- Pp. 1-7 (7)

Mihail Lucian Pascu

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Pendant Droplets - Microfluidic Approach

- Pp. 8-23 (16)

Viorel Nastasa, Angela Staicu and Mihail Lucian Pascu

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Pendant Droplets - Optofluidic Approach

- Pp. 24-40 (17)

Mihail Lucian Pascu, Angela Staicu and Mihai Boni

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Profile Analysis Tensiometry for Studies of Liquid Interfacial Dynamics

- Pp. 41-74 (34)

Joo Y. Won, Vamseekrishna Ulaganathan, Ayim Tleuova, Talmira Kairaliyeva, Altynay A. Sharipova, Xiu W. Hu, Mohsen Karbaschi, Georgi Gochev, Aliyar Javadi, Mohammad Taeibi Rahni, Alexander V. Makievski, Jürgen Krägel, Saule B. Aidarova and Reinhard Miller

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Pendant Droplets: Overview of Dynamics and Applications

- Pp. 75-111 (37)

Daulet Izbassarov and Metin Muradoglu

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Multiple Drug Resistance: An Up-Date

- Pp. 112-137 (26)

Ruxandra Pirvulescu, Mihaela Oana Romanitan and Alina Popa- Cherecheanu

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Laser Beam Properties

- Pp. 138-149 (12)

Mihail Lucian Pascu

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Unresonant Interaction of Laser Beams with Pendant Droplets

- Pp. 150-183 (34)

Ionut Relu Andrei, Mihai Boni and Mihail Lucian Pascu

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Resonant Interaction of Laser Beams with Pendant Droplets

- Pp. 184-218 (35)

Mihail Lucian Pascu, Mihai Boni, Tatiana Tozar, Adriana Smarandache, Alexandru Stoicu and Ionut Relu Andrei

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Microdroplets of Laser Irradiated Drug Solutions: Surface Tension and Contact Angle

- Pp. 219-249 (31)

Ligia Frunza, Irina Zgura, Valeriu Florin Cotorobai, Constantin Paul Ganea and Stefan Frunza

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Interaction of Laser Beams with Medicine Solutions in Bulk

- Pp. 250-292 (43)

Angela Staicu, Adriana Samarandache, Tatiana Tozar, Alexandru Stoicu, Ruxandra Pirvulescu and Mihail Lucian Pascu

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Lasers in Foams and Emulsions Studies

- Pp. 293-337 (45)

Viorel Nastasa, Mihai Boni, Alexandru Stoicu, Andra Dinache, Adriana Smarandache and Mihail Lucian Pascu

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Application of Laser Modified Medicines in Fighting Multiple Drug Resistance Acquired by Microorganisms

- Pp. 338-365 (28)

Tatiana Tozar, Alexandru Stoicu, Viorel Nastasa, Marcela Popa, Adriana Smarandache, Marieta Costache and Mariana Carmen Chi

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Application of Optically Modified Medicines in Fighting Pseudotumours

- Pp. 366-406 (41)

Ruxandra Pirvulescu, Tatiana Tozar, Alexandru Stoicu and Mihail Lucian Pascu

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Interaction of Medicines Exposed to Laser Beams with Fabrics of Interest for Biomedical Applications

- Pp. 407-427 (21)

Ágota Simon and Mihail Lucian Pascu

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Microvolumetric Droplets in Air in Hypergravity Conditions

- Pp. 428-445 (18)

Ágota Simon, Alexandru Stoicu, Tatiana Tozar, Ionuț Relu Andrei, Săndel Simion, Jack J. W. A. van Loon, Alan Dowson and Mihail Lucian Pascu

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Lasing by Optically Pumped Pendant Droplets

- Pp. 446-470 (25)

Mihai Boni, Ionut Relu Andrei, Angela Staicu, Viorel Nastasa and Mihail Lucian Pascu

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Spectroscopy of Microdroplets: An Alternative to the Spectroscopy of Bulky Materials

- Pp. 471-482 (12)

Mihail Lucian Pascu, Adriana Smarandache, Tatiana Tozar and Ionut Relu Andrei

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Subject Index

- Pp. 481-490 (10)

Mihail Lucian Pascu

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Foreword

The book has an inciting title, “Laser Optofluidics in Fighting Multiple Drug Resistance” and is dedicated to a subject of high interest that is a challenge for the biomedical specialists as well as chemists, physicists, public health experts and even outer space applicants: fighting multiple drug resistance acquired by bacteria and tumours in normal and/or extreme conditions.

The editor and the invited authors propose two action lines, each of them implying pluridisciplinary experiments and data interpretation:

  1. Exposure of selected non-antibiotic medicines at UV pulsed laser beams to modify their chemical structure and generate photoproducts with enhanced properties in fighting multiple drug resistance. At the origin, the parent compounds (mainly phenothiazines, quinazolines and hydandoin derivatives) do not have significant effects on bacteria or tumour tissues, but after being exposed to laser radiation in water solutions they generate photoproducts with individual or synergistic effects on biological targets. The book shows most recent results in the action of exposed chlorpromazine and thioridazine on Gram-positive and Gram-negative bacteria and their antibacterial and antibiofilm enhanced activity. Complementary, a report about clinically used methotrexate exposed to continuous wave (UV-Vis) optical radiation emitted by lamps and then utilised on eye pseudotumours evidenced that the mixture of photoproducts has in some cases anti-inflammatory effects higher than the parent compound. Another clinically used cytostatic, 5–Fluorouracil, exposed to UV pulsed nitrogen laser beams evidenced the same effects as methotrexate.
  2. The “simple” identification of the obtained photoproducts constitutes a complex problem since the photochemistry of the processes is quite complicated; consequently, many procedures are utilised with this purpose and the obtained results are described in detail in the book. One speaks about laser spectroscopy (fluorescence), mass spectrometry, thin layer chromatography, UV–Vis and FTIR absorption spectroscopy, microfluidics (surface tension, contact angles, wetting properties) measurements and many others. This is correlated with the rigorous description of microvolumetric droplets as vectors to transport medicines to targets by applying microfluidics methods and procedures. Particular attention is devoted to description of the interaction – unresonant and resonant – between a laser beam and a single droplet which is of atmost interest in biomedical applications since it allows to fast modify the content of a microdroplet and to send parts of it on the target.

In presenting results, the editor took care that the book provides more interdisciplinary and multidisciplinary information about: the laser systems used to modify pendant droplets and bulk solutions, the properties of laser beams with emphasis on those of them which are essential in reported applications, the behaviour of droplets containing medicines exposed to laser radiation in terrestrial gravity and hypergravity conditions, the micro-spectroscopy specific methods to explore droplets’ content.

The hypergravity experiments and results are groundbreaking since they show that microdroplets of chlorpromazine water solutions have better wetting properties when exposed long time to laser beams compared to water at different gravity levels. In general, unexposed/exposed medicine droplets to laser radiation have better wetting ability for cotton as well as activated charcoal target surfaces.

More, new results are shown about the way in which very small concentrations of photoproducts may be seized after exposure of compounds at laser beams, such as an antibiotic like vancomycin. The developed method is based on a microfluidic approach which allows measurement of surface tension at the interface between a gas bubble and the laser exposed solution. It may be also interpreted in terms of cleaning procedure of water from pollutants found at very low concentrations.

This E-book is very well organised in a series of condensed chapters that are illustrated with high quality figures. The text is accessible and easy to read.

The approach of the multiple drug resistance combat in the manner proposed by the editor is ground-breaking and the book opens promising perspectives in solving this threatening issue nowadays in flexible, rapid and adjustable ways.

Jean Pierre Delville
CNRS/University of Bordeaux,
Laboratoire Ondes et Matière d’Aquitaine,
351 Cours de la Libération,
F-33405 Talence,
France


Preface

This book is proposed as a synthesis of inter- and multi-disciplinary results about new and somewhat unconventional methods and means to fight multiple drug resistance acquired by microorganisms and tumours. Essentially, two are the main directions along which the book text is elaborated:

(i) Modification of non-antibiotic medicines by exposing them at un-coherent, or laser optical radiation so that from an initial compound that is not efficient in combating bacteria or tumours one obtains photoproducts which alone or by synergetic action receive bactericide or, possibly, tumouricide properties. Examples are given regarding several classes of medicines, pointing out particular compounds amongst cytostatics, phenothiazines, quinazolines and hydantoins and showing how the generated photoproducts may be identified by methods belonging to spectroscopy, microfluidics, optofluidics, chromatography and mass spectrometry.

(ii) Developing new vectors to transport medicines to targets based on optics and micro-spectroscopy methods. These vectors are microvolumetric droplets of water solutions that contain parent medicines and have two roles. First, is to allow fast modification of their content by exposing them to pulsed laser beams so that photoproducts with bactericide properties are generated via resonant interaction between one beam and one single droplet. The second, is splitting the droplet by its unresonant interaction with another laser beam having suitable properties, so that nano-droplets and micro-droplets are generated which contain the photoproducts and propagate at supersonic or, respectively, subsonic speeds towards the target.

The target readers of the book are medical doctors, physicists, optofluidics and microfluidics specialists, photochemists, biologists, laser spectroscopists as well as specialists in a broad area of domains ranging from delivery methods of medicines using different sorts of fabrics, to the use of multifunctional medicines in outer space missions, after passing hypergravity conditions. A particular target group is constituted by students experimenting in laser spectroscopy, biology, biomedicine, photochemistry, biophotonics and microfluidics since the book provides new and innovative information about behavior of liquid drops, foams, emulsions and bubbles at interaction with laser radiation and the possible applications of the results in the former mentioned fields.

The book is conceived not only as a coherent synthesis of new results, but also as a source of novel ideas, yet untreated, that are proposed to the readers as working variants in future research. This approach would allow, among others, a fast and flexible reaction in the fight against naturally or accidentally occurring multiresistant microorganisms and tumours, with fast enough results to allow a rapid deal with environment unexpected changes.

A particular interest is devoted to the use of laser spectroscopy and related methods for making available multifunctional drugs that may be applied for treatment of humans or for the decontamination of modules during space flights, in the conditions in which confined small spaces are used in isolation regime for long time intervals, as happens in interplanetary missions. Another subject of interest is the micro-lasers or micro-lasing droplets that emit in free space around them and may be used in a large area of biomedical and technological applications.

The editor would like to thank:

  • Dr. Tatiana Tozar for valuable assistance in placing the book text in the printing house template and for detailed checking of figures, tables, list of contributors and abbreviations.
  • Dr. Andra Dinache for final overall critical reading of the text book.
  • Dr. Viorel Nastasa for assistance in internet connections with the printing house.
  • The Laser Spectroscopy Group of the National Institute for Laser, Plasma and Radiation Physics in Bucharest, for the team work that made possible harvesting together this book.

Mihail Lucian Pascu
Laser Department,
National Institute for Laser,
Plasma and Radiation Physics,
Romania

List of Contributors

Editor(s):
Mihail Lucian Pascu




Contributor(s):
S. B. Aidarova
Kazakh National Technical University
Almaty
Kazakhstan


I. R. Andrei
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


M. Boni
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania
/
Faculty of Physics
University of Bucharest
Magurele, Ilfov
Romania


M. C. Chifiriuc
Faculty of Biology
University of Bucharest
Bucharest
Romania
/
Research Institute of the University of Bucharest
Bucharest
Romania


M. Costache
Faculty of Biology
University of Bucharest
Bucharest
Romania


F. Cotorobai
National Institute of Materials Physics
Magurele, Ilfov
Romania


A. Dinache
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


A. Dowson
European Space Agency, European Space Research and Technology Centre, TEC-MMG
Noordwijk
The Netherlands


L. Frunza
National Institute of Materials Physics
Magurele, Ilfov
Romania


S. Frunza
National Institute of Materials Physics
Magurele, Ilfov
Romania


C. P. Ganea
National Institute of Materials Physics
Magurele, Ilfov
Romania


G Gochev
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Institute of Physical Chemistry
Bulgarian Academy of Sciences
Sofia
Bulgaria


X. W. Hu
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
State Key Laboratory of Multiphase Flow in Power Engineering
Xi’an Jiaotong University
Xi'an
P.R. China


D. Izbassarov
Department of Mechanical Engineering
Koc University, Rumelifeneri Yolu, Sariyer
Istanbul
Turkey


A. Javadi
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Chemical Engineering Department
University of Tehran
Tehran
Iran


T. Kairaliyeva
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Kazakh National Technical University
Almaty
Kazakhstan


M. Karbaschi
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany


J. Krägel
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Sinterface Technologies
Berlin
Germany


J. J. W. A. van Loon
Dutch Experiment Support Center, Department of Oral and Maxillofacial Surgery / Oral Pathology
VU University Medical Center & Academic Centre for Dentistry Amsterdam
Amsterdam
The Netherlands
/
European Space Agency, European Space Research and Technology Centre, TEC-MMG
Noordwijk
The Netherlands


A. V. Makievski
Sinterface Technologies
Berlin
Germany


R. Miller
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany


M. Muradoglu
Department of Mechanical Engineering
Koc University, Rumelifeneri Yolu, Sariyer
Istanbul
Turkey


V. Nastasa
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


M. L. Pascu
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania
/
Faculty of Physics
University of Bucharest
Magurele, Ilfov
Romania


R. Pirvulescu
Emergency University Hospital, Ophthalmology Clinic
University of Medicine and Pharmacy “Carol Davila”
Bucharest
Romania


M. Popa
Faculty of Biology
University of Bucharest
Bucharest
Romania
/
Research Institute of the University of Bucharest
Bucharest
Romania


A. Popa-Cherecheanu
Emergency University Hospital, Ophthalmology Clinic
University of Medicine and Pharmacy “Carol Davila”
Bucharest
Romania


M. T. Rahni
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Sharif University
Tehran
Iran


M. O. Romanitan
Södersjukhuset AB, Internmedicin kliniken
Sektion för Neurologi
Stockholm
Sweden


A. A. Sharipova
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Kazakh National Technical University
Almaty
Kazakhstan


S. Simion
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


Á. Simon
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania
/
Faculty of Physics
University of Bucharest
Magurele, Ilfov
Romania


A. Smarandache
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


A. Staicu
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


A. Stoicu
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


A. Tleuova
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany
/
Kazakh National Technical University
Almaty
Kazakhstan


T. Tozar
National Institute for Laser, Plasma and Radiation Physics
Magurele, Ilfov
Romania


V. Ulaganathan
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany


J. Y. Won
Max Planck Institute of Colloids and Interfaces
Potsdam
Germany


I. Zgura
National Institute of Materials Physics
Magurele, Ilfov
Romania




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