Frontiers in Clinical Drug Research- HIV

Volume 4

by

Atta-ur-Rahman, FRS

DOI: 10.2174/97816810852651170401
eISBN: 978-1-68108-526-5, 2018
ISBN: 978-1-68108-527-2
ISSN: 2468-0397 (Print)
ISSN: 2352-5916 (Online)



Indexed in: Scopus.

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learn...[view complete introduction]
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The Development and Clinical Progress on Chemokine Receptor-Based HIV Entry Inhibitors

- Pp. 105-137 (33)

Yi-Qun Kuang

Abstract

Entry of HIV-1 into targeted host cells is a highly ordered multistage process involving first-receptor attachment, co-receptor binding, and membrane fusion. In this chapter, I will present an overview of progress on HIV-1 entry inhibitors with a focus on chemokine receptor-based antagonists. This chapter, at first, will describe the working mechanisms of chemokine receptors, HIV-1 co-receptors CCR5 and CXCR4, during the replication procedure. Then, the antagonists-based on different mechanisms will be presented in detail. At last, it will summarize and explain the distinct promising entry inhibitors based on co-receptors-interacting proteins, which is inspired by our current work.

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