Frontiers in Clinical Drug Research- HIV

Volume 4


Atta-ur-Rahman, FRS

DOI: 10.2174/97816810852651170401
eISBN: 978-1-68108-526-5, 2018
ISBN: 978-1-68108-527-2
ISSN: 2468-0397 (Print)
ISSN: 2352-5916 (Online)

Indexed in: Scopus.

Frontiers in Clinical Drug Research – HIV is a book series that brings updated reviews to readers interested in learn...[view complete introduction]
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Syntheses of FDA Approved Integrase Inhibitor HIV Drugs and Improved Manufacturing using Flow Processing

- Pp. 61-104 (44)

Omobolanle Janet Jesumoroti, Faith Akwi and Paul Watts


A number of new antiviral drugs have made HIV/AIDS a manageable disease by the introduction of integrase strand transfer inhibitors. One of the major concerns is the accessibility of these drugs in lower income countries. Thus, adequate supplies and cost effective syntheses of these drugs via flow technology are of great importance. Presently, there are four integrase strand transfer inhibitors approved by FDA. This chapter will focus on the published synthesis of currently FDA approved integrase inhibitor drugs and other HIV drugs developed through flow technology. Thus hoping that such a review could be useful to scientists and academia desiring a greater understanding of HIV integrase drug development at reduced cost and could serve as a context for further research and possible collaboration with the industry.

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