Frontiers in Clinical Drug Research - Alzheimer Disorder

Volume 7

by

Atta-ur-Rahman, FRS

DOI: 10.2174/97816810856091180701
eISBN: 978-1-68108-560-9, 2018
ISBN: 978-1-68108-561-6
ISSN: 2451-8743 (Print)
ISSN: 2214-5168 (Online)



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Table of Contents

Preface

- Pp. i
Atta-ur-Rahman
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List of Contributors

- Pp. ii-iii (2)
Atta-ur-Rahman
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Deep Brain Stimulation in the Treatment of Alzheimer's disease

- Pp. 1-11 (11)
Angelo Lavano, Giusy Guzzi, Attilio Della Torre, Domenico Chirchiglia, Carmelino Angelo Stroscio, Donatella Gabriele and Giorgio Volpentesta
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ASS234: A New and Promising Anti-Alzheimer Agent

- Pp. 12-25 (14)
Alejandro Romero, Eva Ramos, Ana P. Fernandez, Julia Serrano, Ricardo Martínez-Murillo and Jose Marco-Contelles
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Recent Advances in Alzheimer's Drug Discovery Research

- Pp. 26-98 (73)
Xin-An Liu, Brati Das, Youjun Chen, Zuxin Chen, Yosef Avchalumov, Xu Tian and Sathyanarayanan V. Puthanveettil
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Alzheimer’s Disease and Proteasome: The Therapeutic Development and Management

- Pp. 99-139 (41)
Qunxing Ding and Haiyan Zhu
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Alzheimer´s Disease: Fundamental Concepts, Novel Findings and Therapeutics Outcomes Coming from the Ca2+/cAMP Signalling Interaction

- Pp. 140-157 (18)
Leandro Bueno Bergantin
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Alzheimer's Disease: An Approach for Non- Pharmacological Therapies

- Pp. 158-213 (56)
M. G.V. Gottlieb, V. E. Closs, V. M. Junges, A. von Gunten, Z. C.L. Lindoso, J. P. Rocha, B.J.P. Lopes Filho, C .R. Oliveira and F. Loureiro
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Past and Present Drug Development for Alzheimer's Disease

- Pp. 214-253 (40)
Pratap Kumar Sahu, Prashant Tiwari, Shakti Ketan Prusty and Bharat Bhusan Subudhi
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Subject Index

- Pp. 254-262 (9)
Atta-ur-Rahman
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Preface

The book series, “Frontiers in Clinical Drug Research – Alzheimer Disorders” presents the important recent advancements in the form of cutting edge reviews written by experts. Volume 7 of this eBook series is a compilation of seven well written chapters contributed by prominent researchers in the field. They include articles on brain stimulation, ASS234 – an Anti-Alzheimer agent, Alzheimer's drug discovery research, proteasome, Ca2+/cAMP signalling interaction, non-pharmacological therapies, drug development and other related areas.

Chapter 1 by Lavano et al., discusses the role of deep brain stimulation in the treatment of Alzheimer's disease (AD). In chapter 2, Romero et al., summarize the neuroprotective effects of ASS234 in counteracting several steps in the pathological processes of AD. Liu et al. in chapter 3 focus on recent advances in Alzheimer's drug discovery research. In Chapter 4, Ding and Zhu highlight the basic information and updates on the proteasome system and related cellular complexes.

In chapter 5, Bergantin discusses the fundamental concepts and current therapies to treat AD, including therapeutic outcomes resulting from the Ca2+/cAMP signalling interaction. Chapter 6 by Gottlieb et al., emphasizes the role of different non-pharmacological therapies administered by a multi-professional health team to maintain the acceptable quality of life for the elderly with AD. The last chapter by Sahu et al., discusses the scope and limitations of some currently marketed drugs in the management of AD.

The 7th volume of this book series represents the results of a huge amount of work by many eminent researchers. I am grateful to the authors for their excellent contributions. I would also like to express my gratitude to the editorial staff of Bentham Science Publishers, particularly Mr. Mahmood Alam (Director Publication), Mr. Shehzad Naqvi (Editorial Manager Publications) and Ms. Fariya Zulfiqar (Manager Publications) for their hard work and persistent efforts.


Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman, FRS
Kings College, University of Cambridge
Cambridge
UK




Contributor(s):
Alejandro Romero
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine
Complutense University
Madrid
Spain


Ana P. Fernández
The Neurovascular Research Group, Department of Translational Neurobiology
Cajal Institute (CSIC)
Madrid
Spain


Angelo Lavano
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


Attilio Della Torre
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


A von Gunten
Department of Psychiatry
University Hospital Lausanne
Lausanne
Switzerland


Bharat Bhusan Subudhi
School of Pharmaceutical Sciences
Siksha O Anusandhan Deemed University
Bhubaneswar, Odisha
India


Brati Das
Department of Neuroscience
UConn Health, 263 Farmington Avenue
Farmington, CT
USA


BJP Lopes Filho
Graduate Program in Biomedical Gerontology (GERONBIO) of the School of Medicine
Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre, RS
Brazil


Carmelino Angelo Stroscio
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


CR Oliveira
Psychology Graduate Program
Faculdade Meridional Imed.
Passo Fundo, RS
Brazil


Domenico Chirchiglia
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


Donatella Gabriele
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


Eva Ramos
Department of Pharmacology and Toxicology, Faculty of Veterinary Medicine
Complutense University
Madrid
Spain


F Loureiro
Graduate Program in Biomedical Gerontology (GERONBIO) of the School of Medicine
Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre, RS
Brazil


Giorgio Volpentesta
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


Giusy Guzzi
Unit of Functional Neurosurgery, Department of Medical and Surgical Sciences
University “Magna Graecia”
Catanzaro
Italy


Haiyan Zhu
Department of Biological Sciences
Kent State University
East Liverpool, OH
USA


José Marco-Contelles
Laboratory of Medicinal Chemistry
Institute of General Organic Chemistry (CSIC)
Madrid
Spain


Julia Serrano
The Neurovascular Research Group, Department of Translational Neurobiology
Cajal Institute (CSIC)
Madrid
Spain


JP Rocha
Graduate Program in Biomedical Gerontology (GERONBIO) of the School of Medicine
Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre, RS
Brazil


Leandro Bueno Bergantin
Department of Pharmacology
Universidade Federal de São Paulo (UNIFESP)
São Paulo
Brazil


MGV Gottlieb
Graduate Program in Biomedical Gerontology (GERONBIO) of the School of Medicine
Pontifícia Universidade Católica do Rio Grande do Sul
Porto Alegre, RS
Brazil


Prashant Tiwari
School of Pharmaceutical Sciences
Siksha O Anusandhan Deemed University
Bhubaneswar, Odisha
India


Pratap Kumar Sahu
School of Pharmaceutical Sciences
Siksha O Anusandhan Deemed University
Bhubaneswar, Odisha
India


Qunxing Ding
Department of Biological Sciences
Kent State University
East Liverpool, OH
USA


Ricardo Martínez-Murillo
The Neurovascular Research Group, Department of Translational Neurobiology
Cajal Institute (CSIC)
Madrid
Spain


Sathyanarayanan V Puthanveettil
Department of Neuroscience
The Scripps Research Institute
Jupiter, FL
USA


Shakti Ketan Prusty
School of Pharmaceutical Sciences
Siksha O Anusandhan Deemed University
Bhubaneswar, Odisha
India


VE Closs
Study Group on Cardiometabolic Risk, Aging And Nutrition (GERICEN) of the Institute of Geriatrics and Gerontology (IGG)
Pontifícia Universidade Católica do Rio Grande do Sul.
Porto Alegre, RS
Brazil


VM Junges
Integrated Center for Obesity Treatment (CINTRO)
Porto Alegre, RS
Brazil


Xin-An Liu
Department of Neuroscience
The Scripps Research Institute
Jupiter, FL
USA
/
Department of Neuroscience
Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place
NewYork, NY
USA


Xu Tian
Department of Environmental Sciences and Engineering, School of Public Health
University of North Carolina
Chapel Hill, NC
USA


Yosef Avchalumov
Department of Neuroscience
The Scripps Research Institute
Jupiter, FL
USA


Youjun Chen
Department of Neurology, School of Medicine
University of North Carolina
Chapel Hill, NC
USA


Zuxin Chen
Department of Neuroscience
Icahn School of Medicine at Mount Sinai, One Gustave L. Levy Place
New York, NY
USA


ZCL Lindôso
Federal University of Pelotas
Pelotas, RS
Brazil




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