Frontiers in Anti-Infective Drug Discovery

Volume 7

by

Atta-ur-Rahman , M. Iqbal Choudhary

DOI: 10.2174/97816810856231180701
eISBN: 978-1-68108-562-3, 2018
ISBN: 978-1-68108-563-0
ISSN: 2451-9162 (Print)
ISSN: 1879-663X (Online)



Recommend this eBook to your Library



This book series brings updated reviews to readers interested in advances in the development of anti-infective drug design and discove...[view complete introduction]
US $
Buy Personal eBook
99
Order Library eBook
396
Order Printed Copy
*119
Order PDF + Printed Copy (Special Offer)
*168

*(Excluding Mailing and Handling)

🔒Secure Checkout Personal information is secured with SSL technology

Table of Contents

Preface

- Pp. i-ii (2)
Atta-ur- Rahman and M. Iqbal Choudhary
Download Free

List of Contributors

- Pp. iii-iv (2)
Atta-ur- Rahman and M. Iqbal Choudhary
Download Free

The Role of the Microbiota in the Genesis of Gastrointestinal Cancers

- Pp. 1-44 (44)
Edda Russo and Amedeo Amedei
View Abstract Purchase Chapter

Towards Host Cell-Targeting Therapies to Treat Dengue Virus Infections

- Pp. 45-87 (43)
Cybele C. García, Veronica M. Quintana, Viviana Castilla and Elsa B. Damonte
View Abstract Purchase Chapter

Synergistic Interaction Between Plant Products and Antibiotics Against Potential Pathogenic Bacteria

- Pp. 88-152 (65)
Banasri Hazra, Sutapa Biswas Majee, Subhalakshmi Ghosh and Dhruti Avlani
View Abstract Purchase Chapter

Molecular Modelling Approaches to Antibacterial Drug Design and Discovery

- Pp. 153-222 (70)
Agnieszka A. Kaczor, Prasanthi Medarametla, Damian Bartuzi, Magdalena Kondej, Dariusz Matosiuk and Antti Poso
View Abstract Purchase Chapter

Nucleic Acid Aptamers Against Virulence Factors of Drug Resistant Pathogens

- Pp. 223-248 (26)
Canan Ozyurt, Ozge Ugurlu, Burhan Bora and Serap Evran
View Abstract Purchase Chapter

Overcoming Fungal Multidrug Resistance by Natural Compounds Targeting Efflux Pumps

- Pp. 249-260 (12)
Shweta Singh, Sandeep Hans, Zeeshan Fatima and Saif Hameed
View Abstract Purchase Chapter

The Infections and Hydrogen Sulfide

- Pp. 261-272 (12)
Ravinder R. Gaddam, Piyush Jha and Madhav Bhatia
View Abstract Purchase Chapter

Subject Index

- Pp. 273-279 (7)
Atta-ur- Rahman and M. Iqbal Choudhary
Download Free

Preface

The 7th volume of the book series entitled, “Frontiers in Anti-infective Drug Discovery” comprises seven comprehensively written reviews on therapeutic advances against bacterial, fungal, and viral infections and cancers, and on study of the mechanism of action of various drugs, and drug candidates, including natural products.

Amedei and Russo have reviewed the role of gut microbiota in the on-set and progression of gastrointestinal (GI) cancers in chapter 1. GI cancers are among the most prevalent cancers with complex aetiologies and high mortality rate. Along with many other factors, human gut microbiota has been found to play an important role in GI cancers. GI cancers are multifactorial diseases influenced by genetic and environmental factors, as well as by Helicobacter pylori infection. Association between the gut microorganisms and GI tumours has attracted major scientific interests in recent years. Modern sequencing techniques have been used to understand various features of the complex microbial communities, as well as the mechanisms through which the gut microbiota are involved in carcinogenesis and cancer progression. The authors have provided a detailed description of how microbial dysbiosis (microbial imbalance) contributes to oncogenesis via multiple pathways, including tumour progression and response to the cancer treatments.

Dengue viral fever has emerged as one of the most important epidemics in recent times. Its re-emergence in tropical and sub-tropical regions of the world is causing considerable morbidity and mortality. Currently, no vaccine is available which can protect against four serotypes of the Dengue virus (DENV) which are known to use host’s biological systems to propagate, and cause infections. These host biological processes include cytoplasmic and nuclear structures and components. Damonte et al have reviewed the recent literature in this important area of research in chapter 2. Their emphasis has been on the identification of host factors, and processes which are involved in viral infection.

Plant products have played a key role in the treatment of diseases since antiquity, including treatment of infections in the pre-antibiotics era. With the discovery of natural products and their synthetic analogues with good antibiotic activity, the importance of phytochemicals had diminished. However, with the emergence of antibiotic resistance, the search of new antibiotics including resistance reversal agents from the plant kingdom against novel targets, was globally initiated. Hazra et al in chapter 3 discuss various classes of plant secondary metabolites which have the capacity to serve as resistance modifying agents (RMA), thus helping conventional antibiotics to function again. The authors have discussed various screening approaches protocols which have been successfully used for the discovery of RMAs, as well as approaches to study their possible mechanism of actions. The discovery of plant-based RMAs is thus a powerful new approach for the treatment infections caused by multi-drug resistant bacteria.

Computer-aided drug design (CADD) has emerged as an important tool in the modern drug discovery and development process. CADD approach plays a key role in drug target identification, study of mechanism of action, as well as in the prediction of drug candidates in the initial drug discovery process. However, CADD-predicted compounds are often found to be ineffective in biochemical and cellular assays. Kaczor and his colleagues have reviewed the application and limitations of CADD approach in chapter 4. They critically analyse the strengths and weaknesses of CADD based lead identification in the context of antibacterial drug discovery and emphasize the need to further improve the CADD based methods, as well the need for experimental verification of computational results at an early phase of drug discovery process.

Since the FDA approval of first aptamer-based drug for the treatment of age-related macular degeneration in 2004, interest in therapeutic uses of aptamers has increased substantially. These molecules are capable of specifically binding with proteins, and inhibiting targets such as vascular endothelial growth factor (VEGF), thrombin and other cellular disease targets. These oligonucleotide aptamers are essentially the small molecular equivalent of antibodies, and thus have the advantage of being highly specific and non-immunogenic. Evran et al present a comprehensive review on the applications of small single-stranded RNA and DNA (oligonucleotide aptamers) as targeted therapies against virulence factors of drug resistance microorganisms in chapter 5. Many aptamers have been investigated and developed for the treatment of diseases, such as cancers, HIV, and macular degeneration. The review of Evran et al focuses on recent research on the use of various aptamers as specific blockers of the virulence factors of drug resistant pathogens. The authors have also reviewed the literature on the use of aptamers as biosensors of bacterial toxins.

Fungal skin infections are often difficult to treat completely due to their capacity to go in recession through spore formation. Candida albicans and its multidrug resistant strains are a major cause of superficial, and deep seeded infections in humans and livestock. The review by Hameed et al in chapter 6 addresses the approaches to overcome fungal infections by using natural products, that can act by blocking or modulating the functions of drug efflux pumps in MDR fungal pathogens. These natural products thus provide an excellent opportunity to treat MDR fungal infections, including Candida infections effectively.

Hydrogen sulfide (H2S) is an endogenous gaseous transmitter whose role in the pathophysiology of several diseases has been extensively studied. It has been linked to many important physiological functions and is known to play a significant role in various diseases involving inflammation, fibrosis, and vascular responses. Recent studies indicate the vasoactive, cytoprotective and anti-inflammatory role of hydrogen sulfide. It can regulate viral, bacterial, parasitic, and fungal infections through its function as signalling molecule. Bhatia et. al. has reviewed state-of-the-art understanding about the mechanisms underlying H2S—mediated regulation of different infectious diseases in chapter 7. This can help in developing H2S- releasing drugs as therapeutic molecules. In the absence of effective treatment for many infections, the H2S based therapeutic agents provide a new approach for infection treatment.

The above articles by prominent researchers in chosen fields have made this volume another important treatise for scientists and research scholars. We are grateful to all the authors for their excellent and scholarly contributions for the 7th volume of this internationally recognized eBook series. We hope that like the previous volumes of this internationally reputed book series, the current compilation will also receive a wide readership and appreciation.

The editorial team of Bentham Science Publishers is greatly appreciated for efficient processing and timely management of this publication. The coordination and liaison by Ms Fariya Zulfiqar (Assistant Manager Publications), and leadership of Mr. Mahmood Alam (Director Publications) are duly acknowledged.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
UK

&

M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi Pakistan

List of Contributors

Editor(s):
Atta-ur-Rahman
Kings College
University of Cambridge
Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi, 75270
Pakistan




Contributor(s):
Agnieszka A. Kaczor
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modelling Lab
Faculty of Pharmacy with Division for Medical Analytics
Lublin
Poland
/
School of Pharmacy
University of Eastern Finland
Kuopio
Finland


Amedeo Amedei
Department of Experimental and Clinical Medicine, Viale Pieraccini 6
University of Florence
Florence
Italy


Antti Poso
School of Pharmacy
University of Eastern Finland
Kuopio
Finland


Banasri Hazra
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India


Burhan Bora
Faculty of Science, Department of Biochemistry
Ege University
Bornova-Izmir
Turkey


Canan Ozyurt
Faculty of Science, Department of Biochemistry
Ege University
Bornova-Izmir
Turkey


Cybele C. García
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires (UBA)
Buenos Aires
Argentina
/
IQUIBICEN
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA
Buenos Aires
Argentina


Damian Bartuzi
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modelling Lab
Faculty of Pharmacy with Division for Medical Analytics
Lublin
Poland


Dariusz Matosiuk
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modelling Lab
Faculty of Pharmacy with Division for Medical Analytics
Lublin
Poland


Dhruti Avlani
Division of Pharmaceutics, NSHM Knowledge Campus
Kolkata-Group of Institutions
Kolkata 700053
India


Edda Russo
Department of Experimental and Clinical Medicine, Viale Pieraccini 6
University of Florence
Florence
Italy


Elsa B. Damonte
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires (UBA)
Buenos Aires
Argentina
/
IQUIBICEN
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET)-UBA
Buenos Aires
Argentina


Madhav Bhatia
Department of Pathology and Biomedical Science
University of Otago-Christchurch
Christchurch
New Zealand


Magdalena Kondej
Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modelling Lab
Faculty of Pharmacy with Division for Medical Analytics
Lublin
Poland


Ozge Ugurlu
Faculty of Science, Department of Biochemistry
Ege University
Bornova-Izmir
Turkey


Piyush Jha
Department of Pathology and Biomedical Science
University of Otago-Christchurch
Christchurch
New Zealand


Prasanthi Medarametla
School of Pharmacy
University of Eastern Finland
Kuopio
Finland


Ravinder R. Gaddam
Department of Pathology and Biomedical Science
University of Otago-Christchurch
Christchurch
New Zealand


Saif Hameed
Amity Institute of Biotechnology
Amity University Haryana
Gurugram (Manesar)
India


Sandeep Hans
Amity Institute of Biotechnology
Amity University Haryana
Gurugram (Manesar)
India


Serap Evran
Faculty of Science, Department of Biochemistry
Ege University
Bornova-Izmir
Turkey


Shweta Singh
Amity Institute of Biotechnology
Amity University Haryana
Gurugram (Manesar)
India


Subhalakshmi Ghosh
Department of Pharmaceutical Technology
Jadavpur University
Kolkata 700032
India


Sutapa Biswas Majee
Division of Pharmaceutics, NSHM Knowledge Campus
Kolkata-Group of Institutions
Kolkata 700053
India


Verónica M. Quintana
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires (UBA)
Buenos Aires
Argentina


Viviana Castilla
Laboratorio de Virología, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales
Universidad de Buenos Aires (UBA)
Buenos Aires
Argentina


Zeeshan Fatima
Amity Institute of Biotechnology
Amity University Haryana
Gurugram (Manesar)
India




Advertisement

Nobel LaureateFocus Medica


Webmaster Contact: info@benthamscience.org Copyright © 2018 Bentham Science