Frontiers in Stem Cell and Regenerative Medicine Research

Volume 8

by

Atta-ur-Rahman, FRS , Shazia Anjum

DOI: 10.2174/97816810858901180801
eISBN: 978-1-68108-589-0, 2018
ISBN: 978-1-68108-590-6
ISSN: 2467-9593 (Print)
ISSN: 2352-7633 (Online)



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Stem cell and regenerative medicine research is a hot area of research which promises to change the face of medicine as it will be pra...[view complete introduction]
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Table of Contents

Preface

- Pp. i
Atta-ur- Rahman and Shazia Anjum
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List of Contributors

- Pp. ii-iii (2)
Atta-ur- Rahman and Shazia Anjum
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Alternative Models of Cancer Stem Cells: Implications for Translational Oncology

- Pp. 1-54 (54)
Vivek Kaushik, Juan Sebastian Yakisich, Neelam Azad and Anand Krishnan V. Iyer
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Unravelling Mesenchymal Stem Cell Signature in Regenerative Medicine

- Pp. 55-129 (75)
Genni Desiato, Morris Losurdo, Chiara A. Elia, Anna Saccomano and Silvia Coco
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Stem Cells in Orthopaedic Injuries

- Pp. 130-149 (20)
Bogdan A. Matache, Stephanie C. Petterson and Kevin D. Plancher
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Stem Cells in Endocrinology: Facts and Future

- Pp. 150-167 (18)
Hugo Mendieta Zeron, Araceli Hinojosa Juarez and Joel Vargas Hernandez
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Tissue Engineering and Wound Healing Biomaterials

- Pp. 168-201 (34)
Nelisa T. Lacin, Murat Demirbilek and Volkan Yalman
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Theoretical Models of Hematopoietic Cell Dynamics Related to Bone Marrow Transplantation

- Pp. 202-241 (40)
Radu Precup, Delia Dima, Ciprian Tomuleasa, Marcel-Adrian Serban and Lorand-Gabriel Parajdi
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Subject Index

- Pp. 242-251 (10)
Atta-ur- Rahman and Shazia Anjum
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Preface

The field of regenerative medicine continues to develop rapidly with many exciting advances. In the first chapter of this 8th volume Iyer et al. provide some promising alternative models of cancer stem cells, their clinical implications and discuss potential strategies to develop certain effective therapeutic regimens for cancer treatment. These alternative models include the Stemness Phenotype Model, the Complex System Model, the Dynamic CSC Model and the Reprogramming Model.

In Chapter 2, Coco et al. describe the use of microvesicles and exosomes in mesenchymal stem cell (MSCs). They discuss the several MSC based clinical trials developed for organ injuries, systemic diseases, chronic inflammatory and autoimmune pathologies as well as the possibility of using less immunogenic and more specific MSC byproducts (i.e. microvesicles and exosomes) to overcome MSC transplantation criticisms and side effects.

Stem cells have also generated significant scientific interest to treat common orthopaedic conditions due to their intrinsic behavior. Petterson et al. discuss the clinical implications of autologous and allogenic stem cell use in the treatment of orthopaedic injuries in chapter 3. In the next chapter, Zeron et al. discuss the progress being made in the use of stem cells in the field of endocrinology.

In chapter 5, Laçin et al. present new developments in biological and engineering principles in wound healing applications to achieve tissue repair and regeneration. These include a review of biomaterials, polymer-based dressing, films, hydrogels, current scaffolds, etc. used in wound healing applications. Functional dressings and bioactive matrices for wound healing in clinical trials are discussed.

Precup et al. in chapter 6 present an overview of theoretical studies on hematopoietic cell dynamics related to bone marrow transplantation. Selected allogeneic and autologous stem cell transplantations models are presented.

We hope that the readers will enjoy the comprehensive reviews on new developments in stem cell and regenerative medicine research. We thank the editorial staff of Bentham Science Publishers, particularly Dr. Faryal Sami, Mr. Shehzad Naqvi and Mr. Mahmood Alam for their help and support.

Prof. Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK

&

Dr. Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur, Bahawalpur
Pakistan



List of Contributors

Editor(s):
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


Shazia Anjum
Department of Chemistry
Cholistan Institute of Desert Studies
The Islamia University of Bahawalpur
Pakistan




Contributor(s):
Anand Krishnan V. Iyer
Department of Pharmaceutical Sciences, School of Pharmacy
Hampton University
VA
USA


Anna Saccomano
School of Medicine and Surgery
University of Milano Bicocca
Monza
Italy


Araceli Hinojosa Juárez
Faculty of Medicine
Autonomous University of the State of Mexico (UAEMex), “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS) and Ciprés Grupo Médico S.C. (CGM)
Toluca
Mexico


Bogdan A. Matache
Orthopaedic Foundation
Stamford
CT
USA
/
Division of Orthopaedic Surgery
University of Ottawa
Ottawa, ON
Canada


Chiara A. Elia
IRCCS Humanitas
Rozzano
Italy


Ciprian Tomuleasa
Department of Hematology
Ion Chiricuţă Oncology Institute
Cluj-Napoca
Romania
/
Iuliu Haţieganu
University of Medicine and Pharmacy
Cluj-Napoca
Romania


Delia Dima
Department of Hematology
Ion Chiricuţă Oncology Institute
Cluj-Napoca
Romania


Genni Desiato
School of Medicine and Surgery
University of Milano Bicocca
Monza
Italy
/
School in Neuroscience
University of Milano Bicocca
Monza
Italy
/
IRCCS Humanitas
Rozzano
Italy


Hugo Mendieta Zerón
Faculty of Medicine
Autonomous University of the State of Mexico (UAEMex), “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS) and Ciprés Grupo Médico S.C. (CGM)
Toluca
Mexico


Joel Vargas Hernández
Faculty of Medicine
Autonomous University of the State of Mexico (UAEMex), “Mónica Pretelini Sáenz” Maternal-Perinatal Hospital (HMPMPS) and Ciprés Grupo Médico S.C. (CGM)
Toluca
Mexico


Juan Sebastian Yakisich
Department of Pharmaceutical Sciences, School of Pharmacy
Hampton University
VA
USA


Kevin D. Plancher
Orthopaedic Foundation
Stamford
CT
USA
/
Plancher Orthopaedics & Sports Medicine
1160 Park Avenue
New York, NY
USA
/
Department of Orthopaedics
Albert Einstein College of Medicine
New York, NY
USA


Lorand-Gabriel Parajdi
Department of Mathematics
Babeş–Bolyai University
Cluj-Napoca
Romania


Marcel-Adrian Şerban
Department of Mathematics
Babeş–Bolyai University
Cluj-Napoca
Romania


Morris Losurdo
School of Medicine and Surgery
University of Milano Bicocca
Monza
Italy
/
PhD School in Neuroscience
University of Milano Bicocca
Monza
Italy


Murat Demirbilek
Advanced Technologies Application and Research Center
Hacettepe University
Istanbul
Turkey


Neelam Azad
Department of Pharmaceutical Sciences, School of Pharmacy
Hampton University
VA
USA


NelisaT Laçin
Department of Molecular Biology and Genetics
Yıldız Technical University
Istanbul
Turkey
/
Advanced Technologies Application and Research Center
Hacettepe University
Istanbul
Turkey


Radu Precup
Department of Mathematics
Babeş–Bolyai University
Cluj-Napoca
Romania


Silvia Coco
School of Medicine and Surgery
University of Milano Bicocca
Monza
Italy
/
PhD School in Neuroscience
University of Milano Bicocca
Monza
Italy


Stephanie C. Petterson
Orthopaedic Foundation
Stamford
CT 06905
USA


Vivek Kaushik
Department of Pharmaceutical Sciences, School of Pharmacy
Hampton University
VA
USA


Volkan Yalman
Department of Molecular Biology and Genetics
Yıldız Technical University
Istanbul
Turkey




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