Chapter 2

Basic Sciences Behind BMAC and Expanded Stem Cells

Mohamed Ahmed Mandour, Asmaa Kamal Abdel Maogood, Eman Gamal Ahmed and Rania Mohammed Kishk

Abstract

Bone Marrow (BM) is a major hematopoietic organ in the human body being the main primary lymphoid organ; it is the source of production of all blood lineages. These cells are produced through an interaction between BM hematopoietic cells and the surrounding microenvironment in a unit called the stem cell niche that involves several cytokines, growth factors and transcriptional factors. The following chapter will entail an overview of MSCs, their isolation and clinical application.

Total Pages: 5-21 (17)

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