Editors: Asghar Ghasemi, Khosrow Kashfi, Zahra Bahadoran

The Role of Nitric Oxide in Type 2 Diabetes

eBook: US $79 Special Offer (PDF + Printed Copy): US $126
Printed Copy: US $87
Library License: US $316
ISBN: 978-981-5079-82-1 (Print)
ISBN: 978-981-5079-81-4 (Online)
Year of Publication: 2022
DOI: 10.2174/97898150798141220101

Introduction

Type 2 diabetes (T2D) is a complex metabolic disorder characterized by impaired glucose metabolism and pancreatic β-cell dysfunction. No effective treatments are available for T2D, although there have been many developments in the therapeutic arena. Nitric oxide (NO) is an endocrine agent with multiple and important biological roles in most mammalian tissues. NO has emerged as a central regulator of energy metabolism and body composition. NO bioavailability is decreased in T2D. Several of the pharmaceuticals used in T2D affect the NO system and perhaps even more so by the drugs we use to treat diabetic cardiovascular complications. Experimental works in animal models of T2D show promising results with interventions aimed to increase NO signaling. However, translation into human studies has so far been less successful, but more large-scale prolonged studies are clearly needed to understand its role.

This book is a collection of reviews that deal with the role of nitric oxide in type 2 diabetes, providing a unique overview of NO signaling, and pointing out key areas for more detailed research. The book includes contributions about the pathophysiology of T2D, a brief history of discovery and timeline of NO research, a comprehensive overview of impaired NO metabolism in T2D, precursors of NO (i.e., L-arginine, L-citrulline, nitrate, nitrites, and NO donors), NO and T2D from genetic points of view, NO and diabetic wound healing, NO and osteoporosis, NO and hyperuricemia, NO and Alzheimer’s Disease, therapeutic applications of NO and NO donors in T2D. The compilation is of great value to anyone interested in the biochemistry of NO and its relationship to diabetes.

Audience

Biochemists, researchers, physicians, endocrinologists, biologists

Foreword

- Pp. i-ii (2)
Eddie Weitzberg
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Preface

- Pp. iii-vi (4)
Khosrow Kashfi, Asghar Ghasemi, Zahra Bahadoran
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List of Contributors

- Pp. vii-viii (2)

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Pathophysiology of Type 2 Diabetes: A General Overview of Glucose and Insulin Homeostasis

- Pp. 1-26 (26)
Asghar Ghasemi*, Khosrow Kashfi
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Nitric oxide: A Brief History of Discovery and Timeline of its Research

- Pp. 27-38 (12)
Asghar Ghasemi*, Khosrow Kashfi
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Impaired Nitric Oxide Metabolism in Type 2 Diabetes: At a Glance

- Pp. 39-66 (28)
Zahra Bahadoran, Mattias Carlström, Parvin Mirmiran, Asghar Ghasemi*
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Asymmetrical Dimethyl Arginine, Nitric Oxide, and Type 2 Diabetes

- Pp. 67-86 (20)
Zahra Bahadoran, Mattias Carlström, Parvin Mirmiran, Asghar Ghasemi*
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Nitric Oxide-Related Oral Microbiota Dysbiosis in Type 2 Diabetes

- Pp. 87-106 (20)
Zahra Bahadoran, Pedro González-Muniesa, Parvin Mirmiran, Asghar Ghasemi*
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Nitric Oxide and Type 2 Diabetes: Lessons from Genetic Studies

- Pp. 107-127 (21)
Zahra Bahadoran, Parvin Mirmiran, Mattias Carlström, Asghar Ghasemi*
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Role of Nitric Oxide in Diabetic Wound Healing

- Pp. 128-160 (33)
Hamideh Afzali, Tara Ranjbar, Khosrow Kashfi, Asghar Ghasemi*
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Role of Nitric Oxide in Type 2 Diabetes-Induced Osteoporosis

- Pp. 161-189 (29)
Nasibeh Yousefzadeh, Sajad Jeddi, Khosrow Kashfi, Asghar Ghasemi*
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Hyperuricemia, Type 2 Diabetes and Insulin Resistance: Role of Nitric Oxide

- Pp. 190-209 (20)
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi*
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Therapeutic Management of Type 2 Diabetes: The Nitric Oxide Axis

- Pp. 210-237 (28)
Tara Ranjbar, Jennifer L. O’Connor, Khosrow Kashfi*
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Brain Insulin Resistance, Nitric Oxide and Alzheimer’s Disease Pathology

- Pp. 238-259 (22)
Zhe Pei, Kuo-Chieh Lee, Amber Khan, Hoau-Yan Wang*
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Arginine, Nitric Oxide, and Type 2 Diabetes

- Pp. 260-283 (24)
Parvin Mirmiran, Zahra Bahadoran, Khosrow Kashfi, Asghar Ghasemi*
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Citrulline, Nitric Oxide, and Type 2 Diabetes

- Pp. 284-302 (19)
Parvin Mirmiran, Zahra Bahadoran, Khosrow Kashfi, Asghar Ghasemi*
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Nitrate, Nitrite and Type 2 Diabetes

- Pp. 303-323 (21)
Zahra Bahadoran, Parvin Mirmiran, Khosrow Kashfi, Asghar Ghasemi*
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Potential Applications of Nitric Oxide Donors in Type 2 Diabetes

- Pp. 324-349 (26)
Zahra Bahadoran, Parvin Mirmiran, Mehrnoosh Bahmani, Asghar Ghasemi*
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Subject Index

- Pp. 350-365 (16)

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