Molecular Oncology: Principles and Recent Advances


by

Javier Camacho

DOI: 10.2174/97816080501611120101
eISBN: 978-1-60805-016-1, 2012
ISBN: 978-1-60805-611-8

  
  


Indexed in: Scopus

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, t...[view complete introduction]
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Table of Contents

Foreword , Pp. i

Manfred Schwab

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Preface , Pp. ii

Javier Camacho

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List of Contributors , Pp. iii-vii (5)

Javier Camacho

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Cell Proliferation, Differentiation and Apoptosis , Pp. 3-17 (15)

Miriam Huerta, Carla Angulo, Esther Lopez-Bayghen and Esther Lopez-Bayghen

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I. The Influence of the Environment , Pp. 18-27 (10)

Andrea De Vizcaya-Ruiz and Araceli Hernandez-Zavala

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II. Obesity and Cancer , Pp. 28-32 (5)

Ranier Gutierrez

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III. Estrogens and Cancer , Pp. 33-43 (11)

Jesus Adrian Rodriguez-Rasgado, Flavia Morales-Vasquez, Luz Maria Hinojosa and Javier Camacho

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IV. Example 1: Hepatocellular Carcinoma , Pp. 44-47 (4)

Pablo Muriel

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V. Example 2: Estrogens, Retinoids and Cervical Cancer Development , Pp. 48-63 (16)

Jorge Gutierrez, Enoc Mariano Cortes, Jose Juan Vazquez and Patricio Gariglio

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Oncogenes and Tumor Suppressor Genes , Pp. 64-82 (19)

Patricio Gariglio

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Epigenetics of Cancer , Pp. 83-97 (15)

Claudia M. Garcia-Cuellar and Alfonso Duenas-Gonzalez

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Signal Transduction Pathways in Cancer , Pp. 98-111 (14)

Lucrecia Marquez-Rosado

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Metastasis , Pp. 112-129 (18)

Lucrecia Marquez-Rosado

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Cancer Immunology and Novel Strategies for Immunotherapy , Pp. 130-147 (18)

Alberto Monroy-Garcia, Maria de Lourdes Mora-Garcia and Jorge Hernandez- Montes

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In Vitro and In Vivo Models for Cancer Research , Pp. 148-162 (15)

Julio Isael Perez Carreon and Jorge Melendez Zajgla

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Molecular Diagnosis and Prognosis , Pp. 163-171 (9)

M. Veronica Ponce-Castaneda and Lourdes Cabrera-Munoz

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Chemotherapy and Design of New Antineoplastic Compounds , Pp. 172-191 (20)

Claudia Rivera-Guevara, Maria Elena Bravo-Gomez and Lena Ruiz-Azuara

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Mechanisms of Therapy Resistance in Cancer , Pp. 192-197 (6)

Ivan Restrepo, Cindy Sharon Ortiz and Javier Camacho

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Antisense Oligodeoxyribonucleotides (AS-ODNs) for Cancer Gene Therapy: A Clinical Perspective , Pp. 198-218 (21)

Maria Luisa Benitez-Hess and Luis Marat Alvarez-Salas

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Directions of Future Cancer Research , Pp. 219-222 (4)

Javier Camacho

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Author Index , Pp. 223

Javier Camacho

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Subject Index , Pp. 224-227 (4)

Javier Camacho

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Foreword

The presentation of basic concepts and recent scientific advances is a demanding task to achieve in a single literary resource. This particular and timely combination is excellently accomplished in this book.

Given the broad spectrum of readership that will benefit from this book, it was imperative that the book was prepared by oncologists and scientists not only having demonstrated fundamental expertise in specific fields but who also have general presentation skills. In this manner, the present book reflects the knowledge necessary to communicate molecular aspects of oncology to Graduates and PhD candidates, physicians, oncologists and a broad variety of scientists, among more general readers. It is my pleasure to encourage readers to go through all of the chapters of this well-organized book.

This work represents an extraordinary effort of both, the Editor - Dr. Javier Camacho - and the other authors in order to offer a state-of-the-art scenario and a reliable and extremely valuable information source about basic concepts in molecular oncology.

With no doubt, this book perfectly meets the key features that people interested in molecular oncology books are seeking to find.

Manfred Schwab, Dr. rer. nat
Professor for Genetics
Director, Division of Tumor Genetics
German Cancer Research Center (DKFZ)
Heidelberg, Germany
Editor-in-Chief:
Encyclopedia of Cancer (Springer), Cancer Letters


Preface

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials are currently running for cancer patients, the successful rate is still very low. Therefore, early markers for cancer as well as novel therapeutic targets and drugs are needed. Understanding of the molecular aspects of cancer development, the discovery of new molecular targets and the rational drug design on a molecular basis, with no doubt should help to decrease cancer mortality.

In consideration to these demands, and in view of cancer as a multi-factorial disease, this book describes some of the most important topics related to cancer on a molecular basis. From describing causes of cancer to rational drug design, including molecular diagnosis and prognosis, the book covers many areas of interest to many potential readers. Instead of describing very particular processes at the very fine level, this book integrates information on different cancer topics.

This approach allows the reader to find in a single book the close relationship between causes of cancer, cell and molecular biology of cancer cells and drug design, among other subjects. This book pretends to cover a broad area of interest for people in the cancer field including students, physicians, researchers, policy makers, and people from the pharmaceutical industry.

We sincerely hope this source to be useful in the understanding of cancer and in the design of new strategies to fight against this terrible disease.

Javier Camacho
Centro de Investigacin y de Estudios Avanzados, CINVESTAV
Department of Pharmacology
Avenida Instituto Politcnico Nacional
Mexico

List of Contributors

Editor(s):
Javier Camacho
Centro de Investigación y de Estudios Avanzados
CINVESTAV Avenida Instituto Politécnico Naciona
Mexico




Contributor(s):
Luis Marat Alvarez-Salas
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


Carla Angulo
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


María Luisa Benítez-Hess
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


María Elena Bravo-Gómez
Departamento de Química Inorgánica y Nuclear Laboratorio de Química Inorgánica MedicinalFacultad de Química
Universidad Nacional Autónoma de México
Av. Universidad 3000Ciudad Universitaria
México
D.F, 04510
Mexico


Lourdes Cabrera Muñoz
Departamento de Patología Hospital Infantil de México Federico Gómez
Dr. Márquez 162
México
D.F, 06720
Mexico


Javier Camacho
Department of Pharmacology
Avenida Instituto Politécnico Nacional
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


Enoc Mariano Cortés
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Andrea De Vizcaya-Ruiz
Department of Toxicology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Alfonso Dueñas-González
Instituto de Investigaciones Biomédicas Universidad Nacional Autónoma de México (UNAM), Instituto Nacional de Cancerología
San Fernando No. 22 Tlalpan
Mexico City, 14080
Mexico


Claudia García-Cuellar
Instituto Nacional de Cancerología
San Fernando No. 22 Tlalpan
Mexico City, 14080
Mexico


Patricio Gariglio
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Ranier Gutiérrez
Department of Pharmacology
Avenida Instituto Politécnico Nacional
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Jorge Gutiérrez
Department of Pharmacology
Avenida Instituto Politécnico Nacional
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Jorge Hernández-Montes
FES-Zaragoza National University of México (UNAM)
Avenida Guelatao 66 Iztapalapa
Mexico City , 09230
Mexico


Araceli Hernández-Zavala
Department of Toxicology
Avenida Instituto Politécnico Nacional
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


Luz María Hinojosa
Hospital General “Dr. Manuel Gea González”
Avenida Calzada de Tlalpan
Mexico City, 480014080
Mexico


Miriam Huerta
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Esther López-Bayghen
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Lucrecia Márquez-Rosado
Public Health Sciences Division Fred Hutchinson Cancer Research Center
1100 Fairview Avenue North
Seattle
WA , 98109
USA


Jorge Meléndez Zajgla
Instituto Nacional de Medicina Genómica (INMEGEN)México
Periférico Sur 4124 Torre Zafiro II, piso 5
Mexico
D.F, 011900
Mexico


Alberto Monroy-García
Oncology Hospital
National Medical Centre, National University of México (UNAM)
IMSS and FES-Zaragoza
Mexico City, 09230
Mexico


María de Lourdes Mora-García
FES-Zaragoza, National University of México (UNAM)
Avenida Guelatao 66. Iztapalapa
Mexico City , 09230
Mexico


Flavia Morales-Vásquez
Instituto Nacional de Cancerología
San Fernando No. 22, Tlalpan
Mexico City, 14080
Mexico


Pablo Muriel
Department of Pharmacology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N 2508
Mexico City, 07360
Mexico


Cindy Sharon Ortiz
Department of Pharmacology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


Julio Isael Pérez-Carreon
Instituto Nacional de Medicina Genómica (INMEGEN)México
Periférico Sur 4124 Torre Zafiro II, piso 5
D.F, 011900
Mexico


M. Verónica Ponce Castañeda
Unidad de Investigación Médica en Enfermedades Infecciosas
Hospital de Pediatría
CMN SXXI, IMSS, Av. Cuauhtémoc
D.F, 330
Mexico


Iván Restrepo
Department of Pharmacology
Avenida Instituto Politécnico Naciona
Centro de Investigación y de Estudios Avanzados del I.P.N. 2508
Mexico City, 07360
Mexico


Claudia Rivera Guevara
Departamento de Química Inorgánica y Nuclear Laboratorio de Química Inorgánica Medicinal Facultad de Química
Universidad Nacional Autónoma de México
Av. Universidad 3000 Ciudad Universitaria México
D.F, 04510
Mexico


Jesús Adrián Rodríguez-Rasgado
Department of Pharmacology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N
Mexico City, 07360
Mexico


Lena Ruiz-Azuara
Departamento de Química Inorgánica y Nuclear Laboratorio de Química Inorgánica Medicinal Facultad de Química
Universidad Nacional Autónoma de México
Av. Universidad 3000 Ciudad Universitaria México
D.F, 04510
Mexico


José Juan Vázquez
Department of Genetics and Molecular Biology
Avenida Instituto Politécnico Nacional 2508
Centro de Investigación y de Estudios Avanzados del I.P.N, 2508
Mexico City, 07360
Mexico




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