Lung Macrophages in Health and Disease


by

Sandra Hodge

DOI: 10.2174/97816080502081090101
eISBN: 978-1-60805-020-8, 2009
ISBN: 978-1-60805-314-8

  
  


Indexed in: Scopus

This Ebook is edited by Sandra Hodge, a recognized expert in the field of macrophage dysfunction in chronic lung disease. The book con...[view complete introduction]
PDF US $
- Single user / Non-Library usage: 49
- Multi user / Library usage: 196
Print-On-Demand (P.O.D): *59
Special Offer for Single user / Non-Library usage (PDF + P.O.D): *83

*(Excluding Mailing and Handling)
Purchase: Book Chapters
Download Flyers

Table of Contents

Foreword , Pp. i

William Vandivier
Download Free

Preface , Pp. ii

Sandra Hodge
Download Free

Contributors , Pp. iii-iv (2)

Sandra Hodge
Download Free

Pulmonary Surfactant Homeostasis and Altered Macrophage Function , Pp. 1-13 (13)

S. W. Glasser and A. P. Senft
Purchase Chapter

Regulation of Macrophage Homeostasis , Pp. 14-36 (23)

Tracey L Bonfield
Purchase Chapter

Macrophage Functional Plasticity: Implications for Cancer Progression and Therapy , Pp. 37-51 (15)

Robert D. Stout and Jill Suttles
Purchase Chapter

Critical Clearance: Alveolar Macrophage Recognition of Apoptotic Cells , Pp. 52-61 (10)

Carol Anne Ogden
Purchase Chapter

Defective Clearance of Apoptotic Cells (Efferocytosis) in Chronic Lung Diseases , Pp. 62-75 (14)

Sandra Hodge
Purchase Chapter

Role of Macrophage Phagocytosis of Bacterial Pathogens in Chronic Lung Disease , Pp. 76-87 (12)

Abigail E Taylor and Louise E Donnelly
Purchase Chapter

The Impact of Oxidative and Carbonyl Stress on Cell Function: Functional Consequences for Macrophages , Pp. 88-98 (11)

Paul Kirkham
Purchase Chapter

The Effects of Chronic Alcohol Ingestion on Alveolar Macrophage Function , Pp. 99-106 (8)

Pratibha C. Joshi
Purchase Chapter

Novel Therapeutic Approaches to Improve Efferocytosis for Pulmonary Disease , Pp. 107-117 (11)

Paul N. Reynolds
Purchase Chapter

Index , Pp. 118-119 (2)

Sandra Hodge
Download Free

Abbreviations , Pp. 120

Sandra Hodge
Purchase Chapter

Foreword

Like the gut, the lung resides in a relatively unique, outside-in position, in that it sits squarely within the body while interacting directly with the outside world. The lung’s interaction with ambient air is so extensive that it includes a surface area approaching that of a tennis court. While this tremendous surface area is required for the lung to perform its essential gas-exchange functions, it is also inherently problematic. Because like the tennis court, the lung is literally bombarded daily by thousands of inorganic, organic and microbial intruders, that all harbour “ill-will” to one extent or another. So like the Kenny Roger’s song, “The Gambler”, where accurately reading the eyes of one’s opponent is vital, the lung needs to carefully balance its response to each challenge in order to maximize benefit and limit harm.

Much of the lung’s initial reaction to injury has been thought to depend on the sentinel function of the alveolar macrophage, the “decider” so to speak; the cell that chooses whether a challenge warrants a response and how vigorous that response might be. While this concept of the alveolar macrophage has its merits, it is also limited. It is now understood that the functions regulated by the alveolar macrophage are much more extensive and nuanced than were once conjectured. As is beautifully presented within these pages, the alveolar macrophage not only holds a key position as the first responder to insults, it also performs crucial functions in the maintenance of lung structure, cancer biology and many more. This strategically places the alveolar macrophage at a regulatory checkpoint, critical for the maintenance of homeostasis, ripe for dysregulation to the point of causing disease, and essential to understand for the development of novel therapeutic approaches for acute and chronic disease.

R.W. Vandivier.M.D
University of Colorado at Denver
Denver, CO
USA


Preface

The nine chapters provide a full coverage of macrophage function in both healthy and chronically diseased lungs, starting with regulation of macrophage homoestasis to altered macrophage recognition and clearance of pathogens and apoptotic cells in the lung before moving on to macrophage targeted treatment options for chronic lung diseases. The important problem of oxidative and carbonyl stress in the lung and its impact on macrophage function is discussed. Additional chapters deal with the role of disordered macrophage function in cancer progression and the role of chronic alcohol ingestion of macrophage function

Importantly, the book integrates both respiratory cell biology and clinical medicine. The concept of failed macrophage function with regard to chronic lung disease has recently been the topic of intensive research. Key advances in our knowledge of the cellular and molecular mechanisms involved in defective macrophage function have paved the way for the development of novel diagnostic and therapeutic strategies for diseases such as chronic obstructive pulmonary disease and asthma. For this reason the book can be recommended without reservation to a wide spectrum of readers including students, respiratory cell biologists and respiratory clinicians.

Sandra Hodge
1st April, 2009

List of Contributors

Editor(s):
Sandra Hodge
University of Adelaide
Australia




Contributor(s):
S.W. Glasser
Associate Professor of Pediatrics, Cincinnati Children’s Hospital Medical Center
University of Cincinnati, College of Medicine
Cincinnati
Ohio
USA


A.P. Senft
Lovelace Respiratory Research Institute
Infectious Diseases Program, Albuquerque
New Mexico
USA


Tracey L. Bonfield
Assistant Professor and Director of The Inflammatory Mediator CORE, Department of Pediatrics
Case Western Reserve University, Cleveland
Ohio
USA


Robert D. Stout
Professor, Department of Microbiology and Immunology
University of Louisville School, of Medicine and James Graham Brown Cancer Cente
Louisville
KY
USA


Jill Suttles
Professor, Department of Microbiology and Immunology
University of Louisville School, of Medicine and James Graham Brown Cancer Center
Louisville
KY
USA


Carol Anne Ogden
Immuno-Inflammation Center for Excellence in Drug Discovery
GlaxoSmithKline, Pharmaceuticals
Philadelphia
Pennsylvania
USA


Abigail E. Taylor
Senior Lecurer, Airway Disease, National Heart and Lung Institute
London
UK


Louise E. Donnelly
Senior Lecurer, Airway Disease, National Heart and Lung Institute
London
UK


Paul Kirkham
Royal Society Fellow & Honorary Senior Lecturer
National Heart and Lung Institute, Imperial College
London
UK


Pratibha C. Joshi
Assistant Professor of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine
Emory University and Atlanta VAMC
Decatur
GA
USA


Paul N. Reynolds
Consultant Physician in Respiratory and Sleep Medicine, Department of Thoracic Medicine
Royal Adelaide Hospital
South Australia




Advertisement


Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science