Molecular Mechanism and Morphology in Cancer


by

Misa Nakamura, Kennichi Kakudo

DOI: 10.2174/97816080507341100101
eISBN: 978-1-60805-073-4, 2009
ISBN: 978-1-60805-387-2

  
  


Indexed in: Scopus

The WHO report estimates that 12 million people will be diagnosed with some form of cancer this year. In addition, the report predicts...[view complete introduction]
PDF US $
- Single user / Non-Library usage: 59
- Multi user / Library usage: 236
Print-On-Demand (P.O.D): *71
Special Offer for Single user / Non-Library usage (PDF + P.O.D): *100

*(Excluding Mailing and Handling)
Purchase: Book Chapters
Download Flyers

Table of Contents

Preface , Pp. i-iii (1)

Misa Nakamura

Download Free

Foreword , Pp. ii

Liang Shan

Download Free

Contributors , Pp. iii-iv (2)

Misa Nakamura and Kennichi Kakudo

View Abstract Download Free

Gastrointestinal Stromal Tumors: Mutations of Receptor Tyrosine Kinases and Morphology , Pp. 1-11 (11)

Seiichi Hirota and Koji Isozaki

View Abstract Purchase Chapter

Pathology and Molecular Biology of Renal Neoplasms: Recent Advances and Impacts on Pathological Classification , Pp. 12-41 (30)

Yoji Nagashima, Naohito Kobayashi, Eriko Kagawa, Ichiro Aoki, Yoshiaki Inayama and Masahiro Yao

View Abstract Purchase Chapter

Chemotherapy in malignant gliomas , Pp. 42-56 (15)

Mitsutoshi Nakamura, Keiji Shimada, Hiroyuki Nakase and Noboru Konishi

View Abstract Purchase Chapter

The Role of Bcl-2 in Breast Cancer , Pp. 57-80 (24)

Xiaoyan Li and Qifeng Yang

View Abstract Purchase Chapter

ETS Gene Fusions in Prostate Cancer , Pp. 81-101 (21)

Bo Han

View Abstract Purchase Chapter

New Types of Cell Death: Morphological and Molecular Characteristics , Pp. 102-119 (18)

Takashi Ozaki, Ichiro Mori, Katsuyoshi Tabuse, Takaomi Suzuma, Takeo Sakurai, Misa Nakamura, Emiko Taniguchi and Kennichi Kakudo

View Abstract Purchase Chapter

Thyroid Cancer: Gene Mutation and Morphology of Follicular Cell Carcinomas , Pp. 120-137 (18)

Misa Nakamura, Yaqiong Li, Zhiyan Liu and Kennichi Kakudo

View Abstract Purchase Chapter

Index , Pp. 138-144 (7)

Misa Nakamura and Kennichi Kakudo

View Abstract Download Free

Foreword

Traditionally diagnosis of pathology is established on the basis of morphological findings. In most cases, it provides precise information on human tumors regarding their tissue origins, histological types, differentiation degrees, and stages, and this information is the basis for therapy design. However, the clinical outcome of a tumor is not completely mirrored by its morphology. Tumors with identical morphology and stage may present different clinical behaviors. Emergence of molecular pathology is improving the insufficient situation encountered with morphology alone-based diagnosis. Molecular pathology is a rapidly growing field which allows us to read the tumors as precisely as possible by providing information on their morphology as well as on their molecular signatures. There is no doubt that a new interpretation of human tumors based on both molecular biology and morphology will provide clinically more meaningful information.

The eBook, edited by Drs. Nakamura and Kakudo, provides new insight on some issues in molecular pathology with comprehensive reviews of the recent advances in the most active topics. In the first chapter, Drs. Hirota and Isozaki describe a vivid story of how they defined the gastrointestinal stromal tumors based on their molecular analysis and tumor morphology. In the chapter by Dr. Nagashima et al., the molecular basis responsible for the diversity of renal tumor pathology is discussed thoroughly. Dr. Nakamura et al. discuss another important topic on the genetic status underlying the different responses of morphologically similar gliomas to chemotherapy. Drs. Li and Yang then explain the inconsistent side between morphology and clinical outcome in breast cancer with a review of the theories concerning how the Bcl-2 gene family exerts their pro- or anti-apoptotic effect. Next, Dr. Han emphasizes the significance of chromosomal rearrangements in prostate cancer development and morphology, citing the E26 transformation-specific family as an example. In the chapter by Dr. Ozaki et al., authors describe a new type of cell death (microwave cell death) and discuss the necessity of new criteria combining morphology and molecular biology to identify various cell deaths. Thyroid tumors, in particular the follicular lesions, are well-known for the interobserver variation in pathological diagnosis. In the last chapter, Dr. Nakamura et al. outline the signal pathway alterations underlying the thyroid tumors and discuss the value of molecular analysis in improving the pathological diagnosis.

The biological behavior and the morphology of a tumor are controlled by a complex network of functionally active and inactive signaling pathways. The new knowledge and skills in molecular biology is reshaping the conventional diagnostic approaches for human tumors. It is challenging to integrate the molecular technologies and pathological approaches into a diagnostic algorithm and further to standardize the diagnostic approaches. This eBook provides clues on the rapid integration for tumor diagnosis. It is my pleasure to introduce you this book.

Liang Shan, MD, PhD
Molecular Imaging Editor
National Center for Biotechnology Information
National Institutes of Health


Preface

The WHO report estimates that 12 million people will be diagnosed with some form of cancer this year. In addition, the report predicts that more than 7 million people will die early from the disease. Together, the number of cancer cases and deaths from cancer are expected to increase one percent each year.

Cancer research has advanced remarkably, including the multi-step carcinogenesis theory and the identification of cancer stem cells, and these advancements are being applied to clinical therapies targeting the oncogene. In addition, the function of the gene product is becoming clear through analysis of intracellular signaling of the oncogene. As a result, it has been clarified that cancer morphologies are dependent on the kind of abnormal gene and these differences affect patient mortality.

This book presents summaries by specialists in this area. The book consists of seven chapters. Chapter 1 introduces the establishment of a concept of gastrointestinal stromal tumors and also discusses gain of function mutations of the c-kit gene and platelet-derived growth factor receptor alpha gene. Chapter 2 discusses the relationships between the pathology and molecular biology of each histological type of renal neoplasm and the underlying molecular biological abnormalities. Chapter 3 reviews biological and molecular approaches to glioma classification that have the potential to increase the efficacy of treatments for these tumors. Chapter 4 introduces the role of Bcl-2 in clinicopathology and prognosis of breast cancer. Chapter 5 reviews the roles of ETS gene fusions in prostate cancer, associated with prognosis as well as morphological aspect from the perspective of pathology. Chapter 6 introduces a new type of cell death caused by microwaves and radiofrequency ablation. The author expects that this cell death may be applied in cancer therapy. Chapter 7 reviews specific genetic changes in the process of development and dedifferentiation in thyroid cancer.

In this book, all of the authors demonstrate that correct diagnosis using molecular knowledge is important for cancer therapy.

This theme includes the full range of human diseases with regard to medical genetics, biochemistry, microbiology, immunology, anatomy, pathology, structural biology, molecular cell biology, neuroscience and developmental biology. It would be useful to clinicians and scientists in all medical fields. Finally, we would like to express our sincere appreciation to all of the authors who contributed chapters to this book.

Misa Nakamura, PhD.
Osaka Kawasaki Rehabilitation University

List of Contributors

Editor(s):
Misa Nakamura
Osaka Kawasaki Rehabilitation University
Japan


Kennichi Kakudo
Wakayama Medical University
Japan




Contributor(s):
Seiichi Hirota
Department of Surgical Pathology
Hyogo College of Medicine
Hygo
Japan


Koji Isozaki
Department of Molecular Pathology
Yokohama City University Graduate School of Medicine
Yokohama
Japan


Yoji Nagashima
Department of Molecular Pathology
Yokohama City University Graduate School of Medicine
Yokohama
Japan


Naohito Kobayashi
Department of Molecular Pathology
Yokohama City University Graduate School of Medicine
Yokohama
Japan


Eriko Kagawa
Department of Molecular Pathology
Yokohama City University Graduate School of Medicine
Yokohama
Japan


Ichiro Aoki
Department of Molecular Pathology
Yokohama City University Graduate School of Medicine
Yokohama
Japan


Yoshiaki Inayama
Division of Anatomical and Surgical pathology
Yokohama City University Hospital,
Yokohama
Japan


Masahiro Yao
Deaprtment of Urology
Yokohama City University Graduate School of Medicine
Yokohama
Japan


Mitsutoshi Nakamura
Departments of Pathology
Nara Medical University School of Medicine
Nara
Japan


Keiji Shimada
Departments of Pathology
Nara Medical University School of Medicine
Nara
Japan


Hiroyuki Nakase
Departments of Neurosurgery
Nara Medical University School of Medicine
Nara
Japan


Noboru Konishi
Departments of Pathology
Nara Medical University School of Medicine
Nara
Japan


Xiaoyan Li
Department of Breast Surgery, Qilu Hospital
Shandong University School of Medicine
Shandong
China


Qifeng Yang
Department of Breast Surgery, Qilu Hospital
Shandong University School of Medicine
Shandong
China


Han Bo
Department of Pathology
Shandong University Medical School
Shandong, 02543
China


Takashi Ozaki
Department of Human Pathology,
Wakayama Medical University
Wakayama
Japan


Ichiro Mori
Department of Human Pathology,
Wakayama Medical University
Wakayama
Japan


Katsuyoshi Tabuse
Department of Surgery
National Hospital Organization Osaka Minami Mediccal Center
Osaka
Japan


Takaomi Suzuma
Department of Surgery
National Hospital Organization Osaka Minami Mediccal Center
Osaka
Japan


Takeo Sakurai
Sakurai Breast Clinic
Wakayama
Japan


Misa Nakamura
Department of Rehabilitation
Osaka Kawasaki Rehabilitation University
Osaka
Japan


Emiko Taniguchi
Department of Human Pathology
Wakayama Medical University
Wakayama
Japan


Kennichi Kakudo
Department of Human Pathology
Wakayama Medical University
Wakayama
Japan


Yaqiong Li
Department of Human Pathology
Wakayama Medical University
Wakayama
Japan


Zhiyan Liu
Department of Human Pathology
Wakayama Medical University
Wakayama
Japan




Advertisement


Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science