Current Advances in the Medical Application of Nanotechnology


by

Mark Slevin

DOI: 10.2174/97816080513111120101
eISBN: 978-1-60805-131-1, 2012
ISBN: 978-1-60805-535-7

  
  


Indexed in: Scopus, Chemical Abstracts

Nanotechnology promises new medical therapies, more rapid and sensitive diagnostic and investigative tools for normal and diseased tis...[view complete introduction]
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Table of Contents

Editor’s Note , Pp. i

Mark Slevin
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Foreword , Pp. ii

Jian-Xing Ma
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List of Contributors , Pp. iii

Mark Slevin
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Potential of Nanotechnology in Vascular Imaging and Treatment of Atherosclerosis , Pp. 3-9 (7)

Mark Slevin
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Effective Transvascular Delivery of Chemotherapy into Cancer Cells with Imageable Nanoparticles in the 7 to 10 Nanometer Size Range , Pp. 10-24 (15)

Hemant Sarin
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Nanocrystalline Silver: Use in Wound Care , Pp. 25-31 (7)

Valerie Edwards-Jones
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Nanomedicine and the Treatment of Coronary In-Stent Restenosis - A Clinical Review , Pp. 32-42 (11)

Garry McDowell
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Applications of Nanotechnology in Imaging and Therapy of Cancer , Pp. 43-72 (30)

Xiang-Hong Peng, Debatosh Majumdar and Dong M. Shin
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The Nanotoxicological Influence of Nanoparticles, with Special Reference to the Vasculature , Pp. 73-84 (12)

May Azzawi
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Nanorobots for Endovascular Target Interventions in Future Medical Practice , Pp. 85-106 (22)

Sylvain Martel
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Role of Nanotechnology in the Diagnosis and Treatment of Alzheimer’s Disease , Pp. 107-124 (18)

Kristen M. Jaruszewski, Rajesh S. Omtri and Karunya K. Kandimalla
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Index , Pp. 125-127 (3)

Mark Slevin
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Foreword

Nanotechnology is becoming increasingly important in biomedical research and clinical medicine. Similar to other fields, nanotechnology is believed to have a great future in broad aspects of medicine. For example, nanoparticles can potentially improve drug delivery into targeted cells or specific sites within tissue, overcome drug insolubility, enhance drug penetration across barriers and prolong drug bioavailability or achieve sustained drug release. Nanoparticle-mediated drug delivery is being widely studied, as nanoparticles can encapsulate drugs in broad categories including small molecule compounds, peptides, antibodies, siRNA and DNA. Furthermore, most nanoparticles have excellent storage capacity and can be produced with biocompatible and biodegradable materials. Due to their small size, nanoparticles can carry drugs into cells to reach disease sites, which increases local drug concentrations and reduces systemic toxicities. Nanoparticles are also used to achieve sustained drug release after a single injection and thus reduce the injection frequency. This application is especially attractive for drug delivery to sites which drugs cannot reach in an efficient manner. In addition, the engineering of specialized nanoparticles offers a tremendous promise for improving medical imaging and diagnosis techniques.

Nanotechnology in medicine is a fast growing field with numerous publications each year. The purpose of this eBook is to introduce the rationale for the use of nanotechnology in medicine and summarize recent advances in some specific applications of nanotechnology in medicine. This eBook also provides a perspective on the future development and potential use of nanotechnology in medicine and discusses the current limitations and hurdles in the medical application of nanotechnology. This eBook will be of interest to readers in broad fields, including scientists in drug research and development, biomedical technologists, researchers in nanotechnology, medical doctors with interests in improved drug delivery and diagnosis, as well as students in nanotechnology and drug delivery fields.

The editor of the eBook, Dr. Mark Slevin, is a well established scientist with extensive knowledge in the medical application of nanotechnology. Dr. Slevin has been doing research in nanotechnology for many years, and has published multiple peer-review journal articles, invited reviews and eBook chapters. He is currently serving as Editor-in-Chief for the Journal of Vascular Cell, and Editor of Brain Pathology, Frontiers in Biosciences, Neural Regeneration Research, the Open Circulation and Microvascular Journal, World Journal of Cardiology. Each chapter of the eBook contains an in-depth review of a growing field of medical nanotechnology and has been written by leading experts. This eBook is an excellent resource for anyone interested in the current status and future potential of the utilization of nanotechnology in medicine.

Jian-Xing Ma
Department of Cell Biology
Professor and Laureate Chair in Molecular Medicine
Department of Medicine Endocrinology


List of Contributors

Editor(s):
Mark Slevin
Manchester Metropolitan University
Manchester
UK




Contributor(s):
Mark Slevin
Cell Pathology, School of Biology
Chemistry and Health Science, Manchester Metropolitan University
Manchester
UK


Hemant Sarin
National Institute of Biomedical Imaging and Bioengineering
National Institutes of Health
Bethesda
USA


Valerie Edwards Jones
Research Development, Research, Enterprise & Development
Manchester Metropolitan University
UK


Mai M. H. Mansour
Department of Chemistry & Yousef Jameel Science & Technology Research Center
the American University In Cairo
Cairo
Egypt


Garry McDowell
Edge Hill University
UK


Dong Moon Shin
Emory Winship Cancer Institute, Hematology and Oncology, and Otolaryngology
Academic Development for Emory Winship Cancer Institute and Director of the Emory Winship Cancer Chemoprevention Program
Atlanta
U.S.A


Debatosh Majumdar
Emory University Winship Cancer Research Institute and Center of Cancer Nanotechnology Excellence,
Atlanta
U.S.A


Xiang-Hong Peng
Departments of Biomedical Engineering and Chemistry
Emory University and Georgia Institute of Technology
Atlanta
U.S.A


Heike Hall
ETH Zurich
Department of Materials
Zürich
Switzerland


May Azzawi
School of Biology, Chemistry and Health Science
Manchester Metropolitan University
Manchester
UK


Judith Sendra Cuadal
Biological Unit Manager
Endor Nanotechnologies
Barcelona
Spain


Mercè Morral
Hospital Clínic i Provincial de Barcelona
University of Barcelona
Spain


Sylvain Martel
École Polytechnique de Montréal (EPM) Campus of the University of Montréal
Montréal (Québec)
Canada


Kristen M. Jaruszewski
Division of Basic Pharmaceutical Sciences
Florida A&M University
Tallahassee
FL , 32307
U.S.A


Rajesh S. Omtri
Division of Basic Pharmaceutical Sciences
Florida A&M University
Tallahassee
FL , 32307
U.S.A


Karunya K. Kandimalla
Division of Basic Pharmaceutical Sciences
Florida A&M University
Tallahassee
FL , 32307
U.S.A




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