Pesticide Chemistry and Toxicology

Book Series: Toxicology: Agriculture and Environment

Volume 1

by

Dileep K. Singh

DOI: 10.2174/97816080513731120101
eISBN: 978-1-60805-137-3, 2012
ISBN: 978-1-60805-531-9
ISSN: 2211-2952 (Print)



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Pesticide control involves killing pest organisms or otherwise preventing them from destructive behavior. Pesticides are either natura...[view complete introduction]

Table of Contents

About the Author

- Pp. i

Dileep K. Singh

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Foreword

- Pp. ii

H. C.Agarwal

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Preface

- Pp. iii

Dileep K. Singh

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Acknowledgement

- Pp. iv

Dileep K. Singh

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Keywords

- Pp. v

Dileep K. Singh

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Pesticide Chemistry

- Pp. 3-25 (23)

Dileep K. Singh

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Individual Pesticides

- Pp. 26-49 (24)

Dileep K. Singh

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Toxicology of Pesticides

- Pp. 50-61 (12)

Dileep K. Singh

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Metabolism or Degradation of Pesticides: Phase I and Phase II Reactions

- Pp. 62-96 (35)

Dileep K. Singh

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Toxicological Symptoms

- Pp. 97-103 (7)

Dileep K. Singh

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Pesticide Formulation and Application

- Pp. 104-113 (10)

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Pesticides and Environment

- Pp. 114-121 (8)

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Summary

- Pp. 122-123 (2)

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Terminologies

- Pp. 124-134 (11)

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Index

- Pp. 135-137 (3)

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Unit Conversion Table

- Pp. 138-142 (5)

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Foreword

I am delighted to introduce my student and the author of this book, Dileep K. Singh, an Associate Professor, in the Department of Zoology, University of Delhi, India. He has been teaching 'Pesticide Toxicology' at master level since 1996. He has contributed many research papers on environmental pesticide toxicology in peer reviewed journals with good impact factor. I know him personally and appreciate him for his sound knowledge in pesticide toxicology. He conceived the idea to write a book on pesticide toxicology somewhere in 2006, since then he has been working on it. I have seen his book on 'Pesticide chemistry and toxicology', which is informative and deals with different aspects of toxicology and chemistry associated with the pesticides. I specially appreciate his efforts to include a chapter on 'Pesticide Metabolism', which provides the information about the pesticide degradation in very lucid manner and well explained using figures with target site for pesticide metabolism.

Pesticide Metabolism is typically a two stage process. These are Phase I reactions and Phase II reactions. Phase I reactions, normally add a functional (polar reactive) group to the foreign molecule which enables the phase II reaction to take place. These reactions are catalyzed by the cytochrome P- 450 group of enzymes and other enzymes which are associated with endoplasmic reticulum. Phase I reaction includes microsomal oxidation and extramicrosomal metabolism of pesticides. Phase II reactions are conjugation reactions and involve the covalent linkage of the toxin or phase I product to a polar compound. In general, conjugated products are ionic, polar, less lipid soluble, less toxic and easily excretable from body.

I hope that this book will be very useful to the students of master and graduation level and also to the people working in different fields of pesticide toxicology.

Professor H.C.Agarwal
F.N.A.Sc., F.N.A.A.S. (Retired)
Insect Biochenistry & Toxicolog
Department of Zoology
University of Delhi
India


Preface

As a teacher, I have faced several questions put forward by my students on toxicology such as dose response relationship, carcinogenicity, teratogenicity, mutagenicity, metabolism of toxic chemicals and their behavior in the environment. These queries initiated me to write a book on "Pesticide chemistry and toxicology", which will provide some answers to their questions. In this book, there are eight chapters with subtopics; each is dealing with answers of very specific questions on toxicology. I have tried to pin point the discrepancies raised in my mind as toxicologist and tried to pen down here. I hope this book will be helpful to the students of pesticide toxicology and scientists/teachers working in this field. I am thankful to my colleagues for their continuous support in writing this book and NISCAIR (CSIR, India) for according the approval to use my two chapters hosted on their website. Thanks to Bentham Science publisher who have made publishing this eBook possible.

Dileep K. Singh
Delhi, India

List of Contributors

Author(s):
Dileep K. Singh
University of Delhi
India




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