Frontiers in Cardiovascular Drug Discovery

Volume 1

by

Atta-ur-Rahman, Dr. M.Iqbal Choudhary

DOI: 10.2174/97816080516011100101
eISBN: 978-1-60805-160-1, 2010
ISBN: 978-1-60805-668-2
ISSN: 1879-6648

  
  


Indexed in: Chemical Abstracts

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Table of Contents

Preface , Pp. i

Atta-ur-Rahman and M. Iqbal Choudhary

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Contributors , Pp. ii-vii (6)

Atta-ur-Rahman and M. Iqbal Choudhary

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Statins in Hypertension , Pp. 1-11 (11)

Carlos A. Feldstein

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New Insights into Pharmacogenetics of Statins Therapy , Pp. 12-31 (20)

Luca Puccetti, Maurizio Acampa, Marcello Pastorelli, Vittoria Soldati, Francesca Scarpini and Alberto Auteri

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HDL Elevation and Lipid Lowering Therapy: Current Scenario and Future Perspectives , Pp. 32-60 (29)

Mahesh T. Chhabria, Bhanubhai N. Suhagia and Pathik S. Brahmkshatriya

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New Approaches to Atherosclerotic Cardiovascular Disease: The Potential of Torcetrapib , Pp. 61-72 (12)

Jose Luis Perez-Castrillon and Antonio Duenas-Laita

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Role of Infrasound Pressure Waves in Atherosclerotic Plaque Rupture: A Theoretical Approach , Pp. 73-78 (6)

Athanasios Tsatsaris, Efstathios Koukounaris, Theodoros Motsakos and Despina Perrea

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Advances in the Perioperative Management of Pulmonary Hypertension , Pp. 79-95 (17)

Harish Ramakrishna

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The Role of Small, Dense LDL in Cardiovascular Risk: The Contributions of the Universities of Palermo and Zurich , Pp. 96-104 (9)

Manfredi Rizzo and Kaspar Berneis

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Role of Omega-3 Fatty Acids in Cardiovascular Disease Prevention , Pp. 105-120 (16)

GianLuca Colussi, Cristiana Catena, Elisa Nadalini, Alessandra Chiuch, Alessandro Di Fabio, Marica Valeri and Leonardo A. Sechi

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Chronic Diabetic Complications: Endothelial Cells at the Frontline , Pp. 121-137 (17)

Zia A. Khan and Subrata Chakrabarti

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Oxidative Stress in Cardiovascular Disease: A New Avenue Toward Future Therapeutic Approaches , Pp. 138-153 (16)

Reiko Inagi

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The Clinical Impact of Hyperphosphatemia in Chronic Kidney Disease Patients: The Role of Lanthanum Carbonate , Pp. 154-164 (11)

Mario Cozzolino and Diego Brancaccio

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Myocardial Protection Against Ischemia-Reperfusion Injury: Novel Approaches in Maintaining Homeostatic Stability in Blood , Pp. 165-191 (27)

Maqsood M. Elahi and Bashir M. Matata

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The Role of Angiotensin Type 1 Receptor in Inflammation and Endothelial Dysfunction: Clinical Application , Pp. 192-200 (9)

Dana Skultetyova, Adriena Sakalova, Pavol Chnupa and Slavomira Filipova

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B-Type Natriuretic Peptide for Diagnosis and Therapy , Pp. 201-211 (11)

Marek Jankowski

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Urokinase-An Important Anti-Thromboembolic Drug , Pp. 212-235 (24)

Adinarayana Kunamneni, Bhavani D. Ravuri, Vinjamuri Saisha, Poluri Ellaiah and Taadimalla Prabhakhar

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Anti-Inflammatory Effects of Endothelin Receptor Antagonists and their Importance for Treating Human Disease , Pp. 236-258 (23)

Matthias Barton, Philipp C. Nett, Kerstin Amann and Mauro M. Teixeira

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Levosimendan in Heart Failure , Pp. 259-269 (11)

Charalambos Antoniades, Michael Demosthenous, Dimitris Tousoulis, Costantinos Bakogiannis, Nikolaos Koumallos and Christodoulos Ste

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Thyroid Hormone in Heart Failure: Potential Therapeutic Implications , Pp. 270-287 (18)

Alessandro Pingitore and Giorgio Iervasi

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Skeletal Muscle Derived Stem Cells for Myocardial Repair , Pp. 288-306 (19)

Husnain K. Haider, Lei Ye and Muhammad Ashraf

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A Practical Approach to Diagnosis and Treatment of Symptomatic Thromboembolic Events in Children with Acute Lymphoblastic Leukem , Pp. 307-323 (17)

Paola Giordano, Giovanni Carlo Del Vecchio, Paola Saracco, Marco Zecca, Angelo Claudio Molinari and Domenico De Mattia

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Recent Progress in Pharmacological Research of Antioxidants in Pathological Conditions: Cardiovascular Health , Pp. 324-346 (23)

Milagros Rocha, Remedios Garcia-Bou, Raul Herance, Antonio Hernandez-Mijares and Victor M. Victor

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Author Index , Pp. 347-348 (2)

Atta-ur-Rahman and M. Iqbal Choudhary

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Preface

Recent advances in drug discovery and development are based on post-genomic understanding of human diseases at the cellular as well as molecular levels. Cardiovascular disorders are among the most important group of diseases which have gone through major transformation, both in approach and techniques. The chapters contain in this volume are the updated version of articles published in Recent Patents on Cardiovascular Drug Discovery. This volume comprises well-written reviews contributed by experts in the field of cardiovascular drug discovery and development. Each review summarizes cutting edge researches on a specific approach in CVD treatment. Many of these reviews are focused on the development of various classes of chemical compounds for cardiovascular disease management by interfering in the molecular mechanisms, which lead to atherosclerosis and hypertension.

Most reviews in this volume are written in a way to first introduce the topic and then gradually summarize the important developments in the field in a chronological manner. Thus each review should be of interest not only to professional scientists but also to research students. The references in each review are up-to-date, and represent state-of-the-art developments.

We are grateful to all contributors for their willingness to write short reviews on important aspects of cardiovascular drug discovery and development, as well as, submitting their articles in a timely manner. We are also grateful to the staff of Bentham Science Publishers, especially Mr. Mahmood Alam (Managing Director), Ms. Samina Khan (Senior Manager), Ms. Taqdees Malik (Assistant Manager) and Ms. Sadaf Idrees Khan (Composer), for their untiring efforts to make this assignment a success.

Prof. Dr. Atta-ur-Rahman, FRS
Prof. Dr. M. Iqbal Choudhary
Editors

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan


Prof. Dr. M.Iqbal Choudhary
University of Karachi
Pakistan




Editorial Advisory Board:
Carlos A. Feldstein
Hypertension Program, Hospital de Clínicas José de San Martín
Av. Córdoba 2351
Buenos Aires, 1120
Argentina


Luca Puccetti
Department of Clinical Medicine and Immunology
Section of Internal Medicine
Centre for Atherosclerosis Research
University of Siena
Siena
Italy


Maurizio Acampa
Department of Clinical Medicine and Immunology
Section of Internal Medicine
Centre for Atherosclerosis Research
University of Siena
Siena
Italy


Marcello Pastorelli
Department of Clinical Medicine and Immunology
Section of Internal Medicine
Centre for Atherosclerosis Research
University of Siena
Siena
Italy


Vittoria Soldati
Department of Clinical Medicine and Immunology
Section of Internal Medicine
Centre for Atherosclerosis Research
University of Siena
Siena
Italy


Francesca Scarpini
Department of Clinical Medicine and Immunology
Section of Internal Medicine
Centre for Atherosclerosis Research
University of Siena
Siena
Italy


Alberto Auteri
Department of Clinical Medicine and Immunology
Section of Internal Medicine, Centre for Atherosclerosis Research
University of Siena
Siena
Italy


Mahesh T. Chhabria
Department of Pharmaceutical Chemistry and Quality Assurance
L M College of Pharmacy, Navrangpura, Ahmedabad
Gujarat, 380 009
India


Bhanubhai N. Suhagia
Department of Pharmaceutical Chemistry and Quality Assurance
L M College of Pharmacy, Navrangpura, Ahmedabad
Gujarat, 380 009
India


Pathik S. Brahmkshatriya
Department of Pharmaceutical Chemistry and Quality Assurance
L M College of Pharmacy, Navrangpura, Ahmedabad
Gujarat, 380 009
India


Jose Luis Pérez-Castrillon
Hospital Rio Hortega, University of Valladolid
Valladolid
Spain


Antonio Dueñas-Laita
Hospital Rio Hortega, University of Valladolid
Valladolid
Spain


Athanasios Tsatsaris
Laboratory for Experimental Surgery and Surgical Research
Laboratory of Sanitary Police Department of Grevena
School of Medicine, University of Athens
Athens
Greece


Efstathios Koukounaris
Mechanical Engineering Department of Hellenic Coast Guard
Hellenic Naval Academy
Greece


Theodoros Motsakos
Mechanical Engineering Department of Hellenic Coast Guard
Hellenic Naval Academy
Greece


Despina Perrea
Laboratory for Experimental Surgery and Surgical Research, School of Medicine
University of Athens
Athens
Greece


Harish Ramakrishna
Department of Anesthesiology
Division of Cardiothoracic Anesthesiology
Mayo Clinic, Phoenix
Arizona
USA


Manfredi Rizzo
Department of Clinical Medicine and Emerging Diseases
University of Palermo
Via Maqueda, 175
Palermo, 90133
Italy


Kaspar Berneis
Clinic for Endocrinology, Diabetes & Clinical Nutrition
University Hospital Zurich and Zurich Center for Integrative Human Physiology
University of Zurich
Switzerland


Gian Luca Colussi
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Cristiana Catena
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Elisa Nadalini
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Alessandra Chiuch
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Alessandro Di Fabio
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Marica Valeri
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Leonardo A. Sechi
Department of Experimental and Clinical Pathology and Medicine
Division of Internal Medicine
University of Udine
Udine
Italy


Zia A. Khan
Department of Pathology
University of Western Ontario, London
Lawson Health Research Institute, London
Ontario , N6G 2V4
Canada


Subrata Chakrabarti
Department of Pathology, University of Western Ontario, London
Metabolism and Diabetes Research Program
Lawson Health Research Institute, London
Ontario , N6G 2V4
Canada


Reiko Inagi
Division of Nephrology and Endocrinology, University of Tokyo
School of Medicine, Hongo, Bunkyo-ku
Tokyo , 113-8655
Japan


Mario Cozzolino
Renal Division, San Paolo Hospital
University of Milan
Milan
Italy


Diego Brancaccio
Renal Division, San Paolo Hospital
University of Milan
Milan
Italy


Maqsood M. Elahi
Department of Cardiothoracic Surgery
Faculty of Medicine and Surgery PIC
Lahore
Pakistan


Bashir M. Matata
Liverpool Heart and Chest Hospital NHS Trust, Thomas Drive
Liverpool, L14 3PE
UK


Dana Skultetyova
Dept. Cardiology
National Institute of Cardiovascular Diseases
Bratislava
Slovak Republic


Adriena Sakalova
Dept. Cardiology
Slovak Medical University
Bratislava
Slovak Republic


Slavomira Filipova
Dept. Cardiology
Slovak Medical University
Bratislava
Slovak Republic


Marek Jankowski
Centre Hospitalier de l’Université de Montréal (RCCHUM) and Department of Medicine
Laboratory of Cardiovascular Biochemistry, Centre de Recherche
University of Montreal, 3850 Saint Urbain Street, Montréal
Québec, H2W 1T7
Canada


Adinarayana Kunamneni
Pharmaceutical Biotechnology Division
University College of Pharmaceutical Sciences, Andhra University
Visakhapatnam, 530 003
India


Bhavani D. Ravuri
Pharmaceutical Biotechnology Division
University College of Pharmaceutical Sciences, Andhra University
Visakhapatnam, 530 003
India


Vinjamuri Saisha
Pharmaceutical Biotechnology Division
University College of Pharmaceutical Sciences, Andhra University
Visakhapatnam, 530 003
India


Poluri Ellaiah
Pharmaceutical Biotechnology Division
University College of Pharmaceutical Sciences, Andhra University
Visakhapatnam, 530 003
India


Taadimalla Prabhakhar
Pharmaceutical Biotechnology Division
University College of Pharmaceutical Sciences, Andhra University
Visakhapatnam, 530 003
India


Matthias Barton
University of Zurich, Molecular Internal Medicine
Institute of Laboratory Animal Science
Winterthurer Str. 190
Zurich, 8057
Switzerland


Philipp C. Nett
Department of Visceral and Transplantation Surgery
University Hospital Bern
Bern
Switzerland


Kerstin Amann
Abteilung für Nephropathologie, Klinikum der Friedrich-Alexander
Universität Erlangen-Nürnberg
Glückstraße 11
Erlangen, 91054
Germany


Mauro M. Teixeira
Departamento de Bioquimica e Imunologia
Instituto Ciencias Biologicas, Universidade Federal de Minas Gerais
Belo Horizonte
Brazil


Charalambos Antoniades
1st Cardiology Department
Athens University Medical School
Athens
Greece


Michael Demosthenous
>1st Cardiology Department
Athens University Medical School
Athens
Greece


Dimitris Tousoulis
1st Cardiology Department
Athens University Medical School
Athens
Greece


Costantinos Bakogiannis
1st Cardiology Department
Athens University Medical School
Athens
Greece


Nikolaos Koumallos
1st Cardiology Department
Athens University Medical School
Athens
Greece


Christodoulos Stefanadis
1st Cardiology Department
Athens University Medical School
Athens
Greece


Alessandro Pingitore
Institute of Clinical Physiology, C.N.R.
Pisa
Italy


Giorgio Iervasi
Institute of Clinical Physiology, C.N.R.
Pisa
Italy


Husnain K. Haider
Department of Pathology and Laboratory of Medicine
University of Cincinnati
231-Albert Sabin Way
Ohio, 45267-0529
USA


Lei Ye
National University Medical Institutes
National University of Singapore
Singapore


Muhammad Ashraf
Department of Pathology and Laboratory of Medicine
231-Albert Sabin Way, University of Cincinnati
Ohio, 45267-0529
USA


Paola Giordano
Department of Biomedicine of Evolutive Age
University of Bari
Italy


Giovanni Carlo Del Vecchio
Department of Biomedicine of Evolutive Age
University of Bari
Italy


Paola Saracco
Department of Pediatrics
Hematology Unit, University of Torino
Italy


Marco Zecca
Department of Pediatric Sciences
University of Pavia
Italy


Angelo Claudio Molinari
Department of Haematology and Oncology
Giannina Gaslini Children’s Hospital
Thrombosis and Haemostasis Unit
Genova
Italy


Domenico De Mattia
Department of Biomedicine of Evolutive Age
University of Bari
Italy


Milagros Rocha
University Hospital Doctor Peset Foundation
Avda Gaspar Aguilar 90
Avda Gaspar Aguilar 90
Valencia, 46017
Spain


Remedios García-Bou
University Hospital Doctor Peset Foundation
Avda Gaspar Aguilar 90
Valencia, 46017
Spain


Raul Herance
High Technology Institute-PRBB
Barcelona
Spain


Antonio Hernandez-Mijares
Department of Medicine, University of Valencia
University Hospital Doctor Peset, Endocrinology Service
Avda Gaspar Aguilar 90
Valencia, 46017
Spain


Victor M. Victor
Department of Physiology and CIBERehd, University of Valencia
University Hospital Doctor Peset Foundation
Avda Gaspar Aguilar 90
Valencia, 46017
Spain




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