Reviews in Pharmaceutical and Biomedical Analysis


by

Paraskevas D. Tzanavaras , Constantinos K. Zacharis

DOI: 10.2174/97816080519081100101
eISBN: 978-1-60805-190-8, 2010
ISBN: 978-1-60805-577-7

  
  


Indexed in: Chemical Abstracts, Scopus

Reviews in Pharmaceutical and Biomedical Analysis contains coverage and review of new trends and applications in all areas of pharmace...[view complete introduction]
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Table of Contents

Foreword , Pp. i

Demetrius G. Themelis
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Preface , Pp. ii

Constantinos K. Zacharis and Paraskevas D. Tzanavaras
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Contributors , Pp. iii-v (3)

Constantinos K. Zacharis and Paraskevas D. Tzanavaras
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Metabolomic Analysis of Natural Products , Pp. 1-19 (19)

David M. Pereira M. Pereira, Patricia Valentao, Federico Ferreres and Paula B. Andrade
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Optimizing the Generalization Ability of Artificial Neural Networks in ELISA Protocols by Employing Different Topologies and GENETIC Operators , Pp. 20-29 (10)

Constantinos Kousoulos, Yannis Dotsikas and Yannis L. Loukas
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Bioinformatics Tools for Mass Spectrometry-based Proteomics Analysis , Pp. 30-51 (22)

D. Di Silvestre, S. Daminelli, P. Brunetti and PL. Mauri
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Current Methods for the Quantitative Analysis of Pharmaceutical Compounds from Whole Blood Matrix Using Liquid Chromatography Mass Spectrometry , Pp. 52-62 (11)

Raymond Naxing Xu, Matthew J. Rieser and Tawakol A. El-Shourbagy
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Microbial Cells and Biosensing: A Dual Approach - Exploiting Antibodies and Microbial Cells as Analytical/Power Systems , Pp. 63-75 (13)

Sushrut Arora, Gabriele Pastorella, Byrne Barry, Marsili Enrico and Richard O Kennedy
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Electroanalytical Methods as Tools for Predictive Drug Metabolism Studies , Pp. 76-83 (8)

B. Blankert and J. -M. Kauffmann
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Sample Preparation Overview for the Chromatographic Determination of 1,4-Benzodiazepines in Biological matrices , Pp. 84-107 (24)

Mohammad Nasir Uddin, Victoria F. Samanidou and Ioannis N. Papadoyannis
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Control of the Level of Apoptosis by Different Analytical Techniques , Pp. 108-113 (6)

Małgorzata Starek, Monika Dąbrowska and Jerzy Skuciński
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Cytokinins: Progress and Developments in Analytical Methods , Pp. 114-129 (16)

Jean Wan Hong Yong and Liya Ge and Swee Ngin Tan
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Pressurized Liquid Extraction in Phytochemical Analysis , Pp. 130-148 (19)

Peng Li and Shao-Ping Li
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Index , Pp. 149-151 (3)

Constantinos K. Zacharis and Paraskevas D. Tzanavaras
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Foreword

Analytical chemistry is playing a critical role in many scientific disciplines and certainly pharmaceutical and biomedical sciences are among the most important. Just a quick glance in the international literature can easily prove this statement.

On this basis it is a pleasure to introduce you to this book under the title "Reviews in Pharmaceutical and Biomedical Analysis". The topic of this book is so wide that it would have been a utopia to expect to cover all aspects of pharmaceutical and biomedical analysis in one single volume. However, the reader can find ten very interesting chapters that cover important fields ranging from sample preparation to metabolomics.

The authors of the chapters of the book are distributed in a large number of countries and they certainly are well-respected and experienced researchers. I strongly believe that this e-book will be a valuable assistance to a variety of scientists and of course to students that are involved to the field of Analytical Chemistry and I strongly recommend it.

Demetrius G. Themelis
Associate Professor of Analytical Chemistry
Aristotelian University of Thessaloniki


Preface

The scope of this e-book entitled "Reviews in Pharmaceutical and Biomedical Analysis" is the coverage and review of new trends and applications in all areas of pharmaceutical and biomedical analytical chemistry.

Our intention was to cover all instrumental analytical methods that are applied to the analysis of compounds with pharmaceutical and biomedical interest, including liquid and gas chromatography, electrophoresis & related techniques, mass spectrometry, hyphenated techniques, automated analytical techniques, spectrometry, luminescence, electroanalysis etc.

We were pleased to see that many authors accepted our invitation to contribute to this e-book covering a wide spectrum of fields. The topics in the order of appearance in the e-book include: an insight on the methods used in the metabolomics analysis (LC-MS, GC-MS, HPLC-DAD, NMR) of several natural matrices with protective health potential (Chapter 1); demonstration of the ability of Artificial Neural Networks (ANN) in successfully predicting the response of an Enzyme-linked Immunosorbent assay (ELISA) (Chapter 2); a discussion of the most recent progresses in bioinformatics tools useful in mass spectrometry-based proteomics (Chapter 3); a review of current methods used in quantitative analysis of pharmaceutical compounds from whole blood matrix by liquid chromatography mass spectrometry (Chapter 4); a discussion of how biosensor-based platforms can be used in conjunction with microbial cells for monitoring, environmental and industrial applications (Chapter 5); electroanalytical methods as tools for predictive drug metabolism studies (Chapter 6); a review of sample preparation methodologies prior to the chromatographic determination of benzodiazepines (Chapter 7); a presentation of the most common analytical techniques for the control of the level of apoptosis (Chapter 8); a review on the various analytical methods designed to meet the requirements for cytokinin analyses in complex matrices (Chapter 9); a review on the applications of pressurized liquid extraction technique in phytochemical analysis in last decade (Chapter 10).

We sincerely believe that the book will prove to be a useful contribution to analytical science. We express our appreciation to all of the contributing authors to Bentham Publishers and their team members for the opportunity to publish this volume. Lastly we thank our family members for their support, encouragement and patience during the entire period of this work.

Constantinos K. Zacharis & Paraskevas D. Tzanavaras
Laboratory of Analytical Chemistry
Department of Chemistry
Aristotelian University of Thessaloniki, GREECE

List of Contributors

Editor(s):
Paraskevas D. Tzanavaras
Aristotelian University of Thessaloniki
Greece


Constantinos K. Zacharis
Aristotelian University of Thessaloniki
Greece




Contributor(s):
P.B. Andrade
REQUIMTE/Serviço de Farmacognosia, Faculdade de Farmácia
Universidade do Porto
R. Aníbal Cunha, 164
Porto, 4050-047
Portugal


S. Arora
School of Biotechnology
Dublin City University,
Dublin
Ireland


B. Blankert
Lab. of Pharmaceutical Analysis
University of Mons, Faculty of Medicine & Pharmacy
Belgium


Barry Byrne
School of Biotechnology
Dublin City University
Dublin 9
Ireland


P. Brunetti
Institute for Biomedical Technologies
Proteomics and Metabolomics Unit - CNR
Via Fratelli Cervi, 93, Segrate
Milan, 20090
Italy


M. Dabrowska
Department of Inorganic and Analytical Chemistr
Jagiellonian University, Collegium Medicum
9 Medyczna Str.
Cracow, 30-688
Poland


S. Daminelli
Proteomics and Metabolomics Unit - CNR
Institute for Biomedical Technologies
Via Fratelli Cervi, 93, Segrate
Milan, 20090
Italy


D. Di Silvestre
Proteomics and Metabolomics Unit - CNR
Institute for Biomedical Technologies
Via Fratelli Cervi, 93, Segrate
Milan, 20090
Italy


Y. Dotsikas
Division of Pharmaceutical Chemistry, Department of Pharmacy
University of Athens, Panepistimioupoli Zografou GR
Athens, 157 71
Greece


T.A. El-Shourbagy
Abbott Laboratories, Department of Drug Analysis
100 Abbott Park Road
Abbott Park
IL , 60064-6126
U.S.A


F. Ferreres
Research Group on Quality, Safety and Bioactivity of Plant Foods, Department of Food Science and Technology
Campus University Espinardo
CEBAS (CSIC), P.O. Box 164
Murcia, 30100
Spain


L. Ge
Natural Sciences and Science Education Academic Group
Nanyang Technological University
Singapore


J.-M. Kauffmann
Laboratory of Instrumental Analysis and Bioelectrochemistry
Université Libre de Bruxelles – Institute of Pharmacy
Belgium


C. Kousoulos
Division of Pharmaceutical Chemistry, Department of Pharmacy
University of Athens, Panepistimioupoli Zografou
Athens
GR , 157 71
Greece


P. Li
Faculty of Life Science and Technology
Kunming University of Science and Technology, Kunming
R. Aníbal Cunha, 164
Yunnan
P. R. China


S.P. Li
Institute of Chinese Medical Sciences, University of Macau
R. Aníbal Cunha, 164
Macao SAR
P. R. China


Y.L. Loukas
Division of Pharmaceutical Chemistry, Department of Pharmacy
University of Athens, Panepistimioupoli Zografou
Athens
GR , 157 71
Greece


E. Marsili
National Centre for Sensor Research (NCSR)
School of Biotechnology, Dublin City University
Dublin 9, 4050-047
Ireland


P.L. Mauri
, Proteomics and Metabolomics Unit - CNR
Universidade do Porto
Via Fratelli Cervi, 93, Segrate
Milan, 20090
Italy


R. O’Kennedy
School of Biotechnology
Dublin City University
Dublin 9
Ireland


I.N. Papadoyannis
Laboratory of Analytical Chemistry, Department of Chemistry
Aristotle University of Thessaloniki
Thessaloniki
GR, 541 24
Greece


G. Pastorella
School of Biotechnology
Dublin City University
Dublin 9
Ireland


D.M. Pereira
REQUIMTE/Serviço de Farmacognosia, Faculdade de Farmácia
Universidade do Porto
R. Aníbal Cunha, 164
Porto, 4050-047
Portugal


M.J. Rieser
Department of Drug Analysis
Abbott Laboratories
100 Abbott Park Road
Abbott Park
IL , 60064-6126
U.S.A


V.F. Samanidou
Laboratory of Analytical Chemistry, Department of Chemistry
Aristotle University of Thessaloniki
Thessaloniki
GR, 541 24
Greece


J. Skucinski
Jagiellonian University, Collegium Medicum, Institute of Emergency Medicine
12 Michalowskiego Str.
Cracow
IL , 31-126
Poland


M. Starek
Department of Inorganic and Analytical Chemistry
Jagiellonian University, Collegium Medicum
9 Medyczna Str.
Cracow
IL , 30-688
Poland


Tan S.N.
Natural Sciences and Science Education Academic Group
Nanyang Technological University
Singapore


M.N. Uddin
Department of Chemistry
University of Chittagong
Chittagong, 4331
Bangladesh


P. Valentão
REQUIMTE/Serviço de Farmacognosia
Faculdade de Farmácia, Universidade do Porto
R. Aníbal Cunha, 164
Porto
IL , 4050-047
Portugal


R.N. Xu
Department of Drug Analysis
Abbott Laboratories
100 Abbott Park Road
Abbott Park
IL , 60064-6126
U.S.


J.W.H Yong
Natural Sciences and Science Education Academic Group
Nanyang Technological University
Singapore




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