Frontiers in Drug Design and Discovery

Volume 1

by

Atta-ur-Rahman, Barry A. Springer, Gary W. Caldwell

DOI: 10.2174/97816080519911050101
eISBN: 978-1-60805-199-1, 2005
ISBN: 978-1-60805-669-9
ISSN: 1574-0889

  
  




Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug desig...[view complete introduction]
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Table of Contents

Editorial: "Cutting Edge Tools in Drug Discovery" , Pp. i-ii (2)

Garry W. Caldwell, Atta-ur-Rahman and Barry A. Springer

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Discovering Novel Antibacterial Agents by High Throughput Screening , Pp. 3-16 (14)

Letizia Brandi, Stefania Serina, Margherita Sosio and Sofia Stinchi

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Small Molecule Drug Targeting of RNA , Pp. 17-28 (12)

Guido J.R. Zaman

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Drug Discovery and Design Via High Throughput Screening of Combinatorial Phage-Display Protein- Peptide Libraries , Pp. 29-67 (39)

Karlen Gazarian

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High Throughput Screening: Will The Past Meet The Future? , Pp. 69-86 (18)

Patrick Englebienne

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Variety of the DNA Hybridization Rate and Its Relationship with High Order Structure of Single Stranded Nucleic Acids , Pp. 87-96 (10)

Makoto Tsuruoka

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An Overview of High Throughput Screening at G Protein Coupled Receptors , Pp. 97-111 (15)

Richard M. Eglen

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Developments in Hyphenated Spectroscopic Methods in Natural Product Profiling , Pp. 113-166 (54)

Sylvia Urban and Frances Separovic

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The Role of Kinetics in High Throughput Screening for Drugs , Pp. 167-195 (29)

Agustina Gomez-Hens and M Paz Aguilar-Caballos

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Assessment of iDEA pkEXPRESS™ for The Prediction of Caco-2 Permeabilities , Pp. 197-209 (13)

Cheng-Pang (Matt) Hsu, Garry W. Caldwell, John A. Masucci, Zhengyin Yan and David M. Ritchie

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Exploring the Viability of Metabonomic Urinalysis as a Toxicity Screen Within a Pharmaceutical Drug Discovery Division , Pp. 211-229 (19)

Gregory C. Leo, Gary W. Caldwell, William Hageman, Becky Hastings, Beata Starosciak, Kristin Snyder, Jaclyn Scowcroft and Aaron Kri

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Partition of Solvents and Co-Solvents of Nanotubes: Proteins and Cyclopyranoses , Pp. 231-266 (36)

Francisco Torrens

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Automating Literature-Based Lead Discovery , Pp. 267-286 (20)

Jonathan D. Wren

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Structural Biology in Early Phase Drug Discovery , Pp. 287-296 (10)

Richard Alexander and John Spurlino

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Whole Gene Synthesis: A Gene-O-Matic Future , Pp. 297-341 (45)

Lance Stewart and Alex B. Burgin

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Contributors , Pp. 343-345 (3)

Garry W. Caldwell and Atta-ur-Rahman

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Subject Index , Pp. 347-360 (14)

Garry W. Caldwell and Atta-ur-Rahman

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List of Contributors

Co-Editor(s):
Prof. Atta-ur-Rahman FRS
Higher Education Commission
International Center for Chemical Sciences, University of Karachi
Karachi , 75270
Pakistan


Barry A. Springer
Senior Research Fellow, Drug Discovery, 3-Dimensional Pharmaceuticals, Inc
665 Stockton Drive
Exton
PA , 19341
USA


Gary W. Caldwell
Senior Research Fellow, Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development LLC
Welsh & McKean Roads, PO Box 776
Spring House
PA , 19477
USA




Contributor(s):
Aaron Krikava
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Agustina Gómez-Hens
Department of Analytical Chemistry, Faculty of Sciences
"Marie Curie" Building Annex, Campus of Rabanales, University of Córdoba
Córdoba, 14071
Spain


Alex B. Burgin
deCODE biostructures, Inc
7869 N.E. Day Rd. West, Bainbridge Is
Rome
WA , 98110
USA


Beata Starosciak
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Becky Hastings
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Cheng-Pang (Matt) Hsu
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


David M. Ritchie
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Frances Separovic
School of Chemistry
The University of Melbourne
Parkville Melbourne VIC, 3010
Australia


Francisco Torrens
Institut Universitari de Ciència Molecular, Universitat de València, Dr. Moliner 50
Burjassot (València), E-46100
Spain


Gary W. Caldwell
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Gregory C. Leo
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Guido J.R. Zaman
N.V. Organon, Molecular Pharmacology Unit, P.O. Box 20
BH Oss, 5340
The Netherlands


Jaclyn Scowcroft
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


John A. Masucci
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


John Spurlino
Department of Structural Biology
Johnson and Johnson Pharmaceutical Research and Development
Exton, 19341
Pennsylvania


Jonathan D. Wren
Department of Botany and Microbiology, Advanced Center for Genome Technology
The University of Oklahoma
Norman
OK, 73019
USA


Karlen Gazarian
Department of Molecular Biology and Biotechnology of the Institute of Biomedical Research
Mexican National University
Mexico D.F
Mexico


Kristin Snyder
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Lance Stewart
deCODE biostructures, Inc
7869 N.E. Day Rd. West
Bainbridge Is
WA , 98110
USA


Letizia Brandi
Vicuron Pharmaceuticals, Via R. Lepetit 34
Gerenzano, 21040
Italy


Mª Paz Aguilar-Caballos
Department of Analytical Chemistry, Faculty of Sciences
"Marie Curie" Building Annex, Campus of Rabanales, University of Córdoba
Córdoba, 14071
Spain


Makoto Tsuruoka
School of Bionics & School of Engineering, Tokyo University of Technology
Katakura 1404-1, Hachiouji
Tokyo, 192-0981
Japan


Margherita Sosio
Vicuron Pharmaceuticals, Via R. Lepetit 34
Gerenzano, 21040
Italy


Patrick Englebienne
Biomedical Consultant, Englebienne & Associates
Strijpstraat 21, B-9750
Free University of Brussels, Place Van Gehuchten 4, B-1020
Zingem
Belgium


Richard Alexander
Department of Structural Biology
Johnson and Johnson Pharmaceutical Research and Development
Exton, 19341
Pennsylvania


Richard M. Eglen
DiscoveRx Corp
42501 Albrae St
Fremont
CA , 94358
USA


Sofia Stinchi
Vicuron Pharmaceuticals
Via R. Lepetit 34
Gerenzano, 21040
Italy


Stefania Serina
Vicuron Pharmaceuticals
Via R. Lepetit 34
Gerenzano, 21040
Italy


Stefano Donadio
Vicuron Pharmaceuticals
Via R. Lepetit 34
Gerenzano, 21040
Italy


Sylvia Urban
School of Applied Sciences (Applied Chemistry)
RMIT University
GPO Box 2476V Melbourne VIC
Australia


William Hageman
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Springhouse
PA , 19477-0776
USA


Zhengyin Yan
Johnson & Johnson Pharmaceutical Research and Development,
LLC Welsh & McKean Roads, P.O. Box 776
Spring House
PA , 19477
USA




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