Frontiers in Drug Design and Discovery

Volume 2

by

Atta-ur-Rahman, Gary W. Caldwell, Mohammad Iqbal Choudhary , Michael R. D' Andrea

DOI: 10.2174/97816080520041060201
eISBN: 978-1-60805-200-4, 2006
ISBN: 978-1-60805-670-5
ISSN: 1574-0889 (Print)

  
  


Indexed in: Scopus, EMBASE

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Table of Contents

Editorial: "Biomarkers to Biosensors - Technologies and Applications to Improve the Drug Discovery Process"

- Pp. i-iii (3)

Gary W. Caldwell, Atta-ur-Rahman, Michael R. D'Andrea and M. Iqbal Choudhary

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Strategies of Biomarker Discovery for Drug Development

- Pp. 5-22 (18)

Xiang Jian Lou, S. M. Belkowski, James M. Dixon, Brenda Hertzog, Dan Horowitz, Sergey I. Ilyin, Danielle Lawrence and D. Polkovit

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Protein and Antibody Microarrays: Clues Towards Biomarker Discover

- Pp. 23-33 (11)

Kazue Usui-Aoki, Motoki Kyo, Makoto Kawai, Masatoshi Murakami, Kazuhide Imai, Kiyo Shimada and Hisashi Koga

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The Use of Biomarkers to Detect Cervical Neoplasia and to Diagnose High-Grade Cervical Disease

- Pp. 35-54 (20)

Douglas P. Malinowski

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New Developments in the Field of Protein and Metabolism Assays Aimed at Drug Discovery Processes

- Pp. 55-86 (32)

Kothandaraman Narasimhan, Ponnusamy Sukumar and Mahesh Choolani

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Proteomic Screening for Novel Therapeutic Targets in Kidney Diseases

- Pp. 87-102 (16)

Visith Thongboonkerd

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Aptamer-Based Technologies as New Tools for Proteomics in Diagnosis and Therapy

- Pp. 103-119 (17)

Vittorio de Franciscis and Laura Cerchia

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Recent Developments in Proteomics: Mass Spectroscopy and Protein Arrays

- Pp. 121-150 (30)

Aarohi Kulkarni and Mala Rao

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NMR Spectroscopy Based Metabonomics: Current Technology and Applications

- Pp. 151-173 (23)

Clare A. Daykin and Florian Wulfert

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NMR-Based Metabonomics of Urine from An Exploratory Study of Ciprofibrate in Healthy Volunteers and Patients with Type 2 Diabete

- Pp. 175-191 (17)

Gregory C. Leo, Ewoud J. van Hoogdalem and Martijn B.A. van Doorn

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Chromatography Mass Spectrometry Based Metabonomic Analytical Methods

- Pp. 193-209 (17)

Gary W. Caldwell, Wensheng Lang, Gregory C. Leo, John A. Masucci, William Jones and Andrew Mahan

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OWLS—A Versatile Technique for Drug Discovery

- Pp. 211-223 (13)

Jeremy J. Ramsden

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Cell-Based Biosensors in Proteomic Analysis

- Pp. 225-239 (15)

Spiridon E. Kintzios

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Current Approaches in Natural Biopolymer- Nanoparticle Hybrid Functional Materials: From Drug Delivery to Bio-Detection Applicat

- Pp. 241-258 (18)

Roberta Brayner

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Spectroscopic Analysis of Cell Physiology and Function

- Pp. 259-272 (14)

Mark Riley, Iram Mondaca Fernandez and Pierre Lucas

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Encapsulated Biomolecules Using Sol-Gel Reaction for High-Throughput Screening

- Pp. 273-294 (22)

Kumiko Sakai-Kato, Masaru Kato, Naoko Utsunomiya-Tate and Toshimasa Toyo'oka

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Modeling of Environmentally Sensitive Hydrogels for Drug Delivery: An Overview and Recent Developments

- Pp. 295-331 (37)

Hua Li, Rongmo Luo and K.Y. Lam

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Polyelectrolyte Nanocapsules - Promising Progress in Development of New Drugs and Therapies

- Pp. 333-348 (16)

Silke Krol, Alessandra Gliozzi and Alberto Diaspro

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Contributors

- Pp. 349-352 (4)

Atta-ur-Rahman, Gary W. Caldwell, M. Iqbal Choudhary and Michael R. D’Andrea

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Subject Index to Volume 2

- Pp. 353-365 (13)

Atta-ur-Rahman, Gary W. Caldwell, M. Iqbal Choudhary and Michael R. D’Andrea

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List of Contributors

Co-Editor(s):
Prof. Atta-ur-Rahman FRS
Federal Minister & Advisor to the Prime Minister on Science and Technology
H.E.J Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi
Karachi, 75270
Pakistan



Gary W. Caldwell
Senior Research Fellow, Drug Discovery, Johnson & Johnson Pharmaceutical Research & Development LLC
Welsh & McKean Roads, PO Box 776
Spring House
PA, 19477
USA



Mohammad Iqbal Choudhary
Director (Acting), H.E.J. Research Institute of Chemistry,
International Center for Chemical Sciences, University of Karachi
Karachi
PA, 75270
Pakistan



Michael R. D' Andrea
Principal Scientist, Drug Discovery
Johnson & Johnson Pharmaceutical Research & Development LLC
Welsh & McKean Roads, P.O. Box 776
Spring House
PA, 19477
USA





Contributor(s):
Gary W. Caldwell
Johnson & Johnson Pharmaceutical Research and Development
LLC, Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Stanley M. Belkowski
Johnson & Johnson Pharmaceutical Research and Development
LLC, Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Roberta Brayner
Interfaces, Traitements, Organisation et Dynamique des Systèmes (ITODYS) –UMR-CNRS 7086
Université Paris 7 Denis Diderot, case 7090 ; 2 Place Jussieu
Paris Cedex 05, 75251
France



Laura Cerchia
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR “G. Salvatore”
via S. Pansini 5
Naples, 80131
Italy



Mahesh Choolani
Diagnostic Biomarker Discovery Laboratory, Department of Obstetrics and Gynaecology, National University Hospital
5 Lower Kent Ridge Road
Singapore



Clare A. Daykin
School of Pharmacy, University of Nottingham, University Park
Nottingham, NG7 2RD
UK



Michael R. D'Andrea
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Alberto Diaspro
CNR-INFM, Department of Physics, University of Genoa, via Dodecaneso 33,
Genoa, 16146
Italy



Vittorio De Franciscis
Istituto di Endocrinologia ed Oncologia Sperimentale del CNR "G. Salvatore"
via S. Pansini 5
Naples
CA, 80131
ITALY



James M. Dixon
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Martijn van Doorn
Centre for Human Drug Research
Zernikedreef 10
Leiden
CL , 2333
THE NETHERLANDS



Iram Mondaca Fernandez
Agricultural and Biosystems Engineering, The University of Arizona
1177 E. 4th Street, Shantz Building, Room 403, Tucson
Arizona, 85721
USA



Alessandra Gliozzi
CNR-INFM, Department of Physics, University of Genoa
via Dodecaneso 33
Genoa, 16146
Italy



Brenda Hertzog
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Ewoud J. van Hoogdalem
Johnson & Johnson Pharmaceutical Research and Development, LLC
Turnhoutseweg 30, B-2340
Beerse
Belgium



Dan Horowitz
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Sergey I. Ilyin
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Williams Jones
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Masaru Kato
School of Pharmaceutical Sciences and COE Program in the 21st Century
University of Shizuoka, 52-1 Yada Suruga-ku
Shizuoka
422-8526, Japan
USA



Spiridon E. Kintzios
EMBIO/Laboratory of Plant Physiology, Faculty of Biotechnology, Agricultural University of Athens, Iera Odos 75
Athens, 11855
Greece



Silke Krol
CNR-INFM, Department of Physics, University of Genoa, via Dodecaneso 33
Genoa, 16146
Italy



Aarohi Kulkarni
Division of Biochemical Sciences, National Chemical Laboratory, Pune
Maharashtra, 411008
India



Wensheng Lang
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



K. Y. Lam
Institute of High Performance Computing, National University of Singapore
1 Science Park Road, #01- 01 The Capricorn Singapore Science Park II
Rome, 117528
Singapore



Danielle Lawrence
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Gregory C. Leo
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Hua Li
Institute of High Performance Computing, National University of Singapore
1 Science Park Road, #01- 01 The Capricorn Singapore Science Park II
117528
Singapore



Xing Jian Lou
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Pierre Lucas
Materials Science and Engineering, The University of Arizona
1177 E. 4th Street, Shantz Building, Room 403, Tucson
Arizona, 85721
USA



Rongmo Luo
Institute of High Performance Computing, National University of Singapore
1 Science Park Road, #01- 01 The Capricorn Singapore, Science Park II
Singapore



Andrew Mahan
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Douglas.P. Malinowski
TriPath Oncology
4025 Stirrup Creek Drive, Suite 400, Durham
North Carolina, 27702
USA



John A. Masucci
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Kothandaraman Narasimhan
Diagnostic Biomarker Discovery Laboratory, Department of Obstetrics and Gynaecology, National University Hospital
5 Lower Kent Ridge Road
Singapore



Debbie Polkovitch
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Jeremy J. Ramsden
School of Industrial and Manufacturing Science, Cranfield University
UK



Mala Rao
Division of Biochemical Sciences, National Chemical Laboratory, Pune
Maharashtra, 411008
INDIA



Mark Riley
Agricultural and Biosystems Engineering, The University of Arizona
1177 E. 4th Street, Shantz Building, Room 403, Tucson
Arizona, 85721
USA



Kumiko Sakai-Kato
Research Institute of Pharmaceutical Sciences, Musashino University
1-1-20 Shinmachi, Nishitokyo-shi
Tokyo, 202-8585
JAPAN



Ponnusamy Sukumar
Diagnostic Biomarker Discovery Laboratory, Department of Obstetrics and Gynaecology, National University Hospital
5 Lower Kent Ridge Road
Singapore



Visith Thongboonkerd
Siriraj Proteomics Facility, Medical Molecular Biology Unit, Office for Research and Development
Faculty of Medicine Siriraj Hospital, Mahidol University
12th Fl. Adulyadej Vikrom Bldg., 2 Prannok Rd., Bangkoknoi
Bangkok , 10700
Thailand



Meghan Towers
Johnson & Johnson Pharmaceutical Research and Development, LLC
Welsh and McKean Roads, P.O. Box 776
Spring House
PA , 19477-0776
USA



Toshimasa Toyo'oka
School of Pharmaceutical Sciences and COE Program in the 21st Century
University of Shizuoka
52-1 Yada Suruga-ku
Shizuoka, 422-8526
JAPAN



Naoko Utsunomiya-Tate
Research Institute of Pharmaceutical Sciences
Musashino University
1-1-20 Shinmachi, Nishitokyo-shi
Tokyo, 202-8585
JAPAN



Florian Wülfert
School of Biosciences, University of Nottingham
Sutton Bonington, Loughborough
Leicestershire, LE12 5RD
UK





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