Frontiers in Drug Design and Discovery

Volume 5

by

Atta-ur-Rahman, Mohammad Iqbal Choudhary

DOI: 10.2174/97816080520351100501
eISBN: 978-1-60805-203-5, 2010
ISBN: 978-1-60805-527-2
ISSN: 1574-0889

  
  




Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug desig...[view complete introduction]
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Table of Contents

Preface , Pp. i

Att-ur-Rahman and M. Iqbal Choudhary
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Pegaptanib Sodium in the Treatment of Ocular Vascular Diseases: Expectations and Realities , Pp. 1-16 (16)

Gian Paolo Giuliari and Peter Y. Chang
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Recent Developments in Anxiety Disorders , Pp. 17-40 (24)

David M. Christmas, Geetha Menon and Sean D. Hood
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Development of Novel Synthetic Hydrophilic Resin for Drug-Protein Interaction Analysis , Pp. 41-66 (26)

Akito Tanaka and Takao Isogai
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Selecting an Appropriate Dose-Response Curve in Bioassay Development , Pp. 67-96 (30)

Jason J.Z. Liao, Fenghai Duan, Yuan Meng and Qinjian Zhao
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Biologically Active Benzyl Derivatives of Germanium - Challenges in Chromatographic Separation , Pp. 97-120 (24)

Mariusz Kluska
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Development of New Anti-Cancer Drugs that Block the Kinase Pak1 , Pp. 121-145 (25)

Hiroshi Maruta and Shanta M. Messerli
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Enabling Drug Delivery to Cancer Cells and Tumor Endothelium: the Benefit of Targeted Therapy , Pp. 146-167 (22)

Maria Jeppesen and Torben Moos
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Design of Anti-Fasn Molecules as a New Anti-Tumour Modality , Pp. 168-200 (33)

J. Relat and T. Puig
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Contributors , Pp. 201-202 (2)

Atta-ur-Rahman and M. Iqbal Choudhary
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Preface

Compound and Biological Sample Management in Drug Discovery

The present volume of Frontiers in Drug Design and Discovery and is an excellent compilation of eight well-written review on topics directly revelent to various aspects of drug development and delivery. Giuliari and Chang have contributed a detailed and Wellreferenced review on the use of pegaptanib sodium, a selectiveRNA aptamers antiangiogenic agent, for the treatment of age-related macular degeneration (AMD) and proliferative diabetic-related retinopathy (PDR). Review highlights the promising results of various pre-clinical and clinical studies conducted on pegaptanib sodium. Second review by Tanaka and Isogai deals with the development of a stable synthetic hyprophilic resin which has the capacity of minimizing the non-specific protein absorption, and thus can be employed to characterize the drug-protein interaction. This particular resin can also be used as affinity matrix to isolate specific target proteins for drug research. The thirdarticle, Written by Lio et al., deals with the systematic strategy to select a linear dose range in various bioassay screenings. Thus address an important aspect of correctly analyzing, and interpreting the results of biological screening methods.

Kluska in his review focuses on the challenging task of chromatographic separation of benzyn derivatives, complexed with germanium metal. These compounds are Known to posses a range of biological activities and their separation is often a challenge due to their capacity to irreversibly bound with a variety stationary phases. The review contributed by Jappesen and Moos focuses on targeted drug delivery specifically to the tumor, such as the glioblastoma, multiform. The targeted drug delivery, in such cases is based on properties, such as molecular-signaling pathways or cell surface binding.

Designing of anti-FASN molecules as novel antitumor agents reviewed by Relat and Puig. Fatty acid synthase enzym (FASN) plays an important role in tumor cell survival and malignancy. FASN therefore has been identified as a novel target in anti tumor drug development. The article review the development of FASN-inhibitors and rational designing by anti-FASN agent based on the crystal structure of FASN protein. The last review of Maruta and Messerli also summarizes the extensive work, in last several decades, on the development of anti-PAK I drug, both of synthetic and natural arigin. These drug are specially effective against PAK I-dependent tumors.

In brief, this volume of FDDD bring a delight of interesting readings on various aspects of grug discovery, development and delivery. It is hopped that these well-written, and well-referenced reviews will be of special interest to scientists working in phatmaceutical R&D, as well as researchers of academic institutions, involve in drug discovery, and development.

We wish to extend our gratitide and felicitation to all the authors of this volume for their immensely useful contributions. We also extend our thanks to the editorial staff of the Bentham Science Publishers. The Netherlands, involved in various stages of timly publication of current volume of this important book series.

Att-ur-Rahman
M. Iqbal Choudhary
Pakistan, 2010

List of Contributors

Editor(s):
Prof. Dr. Atta-ur-Rahman FRS
University of Karachi
Pakistan


Prof. Dr. Mohammad Iqbal Choudhary
University of Karachi
Pakistan




Contributor(s):
P.Y. Chang
Massachusetts Eye Research and Surgery Institution
Cambridge
MA
USA


D.M. Christmas
Psychopharmacology Unit
University of Bristol
Bristol , BS1 3NY
UK


F. Duan
Center for Statistical Sciences
Brown University
Providence
RI , 02912
USA


G.P. Giuliari
Massachusetts Eye Research and Surgery Institution
Cambridge
MA
USA


S.D. Hood
School of Psychiatry and Clinical Neurosciences (M521)
University of Western Australia
Perth
Australia


T. Isogai
Graduate School of Pharmaceutical Sciences, The University of Tokyo
Tokyo
Japan


M. Jeppesen
Section of Neurobiology, Biomedicine, Department of Health Science and Technology
Aalborg University
Aalborg University
Denmark


M. Kluska
Institute of Chemistry
University of Podlasie
Siedlce
Poland


J.J.Z. Liao
Merck Research Laboratories
West Point
PA , 19486
USA


H. Maruta
NF CURE Japan
Melbourne, 3055
Australia


Y. Meng
Merck Research Laboratories
West Point
PA , 19486
USA


T. Moos
Section of Neurobiology, Biomedicine, Department of Health Science and Technology
Aalborg University
Denmark


G. Menon
School of Psychiatry and Clinical Neurosciences (M521)
University of Western Australia
Perth
Australia


S.M. Messerli
Marine Biological Laboratory
Woods Hole, Mass.
USA


T. Puig
Institut d'Investigació Biomèdica de Girona (IdIBGi), Hospital Dr. Josep Trueta
Girona, E-17007
Spain


J. Relat
Departament de Bioquímica i Biologia Molecular, Facultat de Farmàcia
Universitat de Barcelona, Av. Diagonal 643
Barcelona, E-08028
Spain


A. Tanaka
Department of Pharmacy
Hyogo University of Health Sciences
Japan


Q. Zhao
Merck Research Laboratories
West Point
PA , 19486
USA




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