Frontiers in Medicinal Chemistry

Volume 5

by

Atta-ur-Rahman , Allen B. Reitz, M. Iqbal Choudhary

DOI: 10.2174/97816080520801100501
eISBN: 978-1-60805-208-0, 2010
ISBN: 978-1-60805-675-0
ISSN: 1567-2042

  
  




Frontiers in Medicinal Chemistry is an Ebook series devoted to the review of ar...[view complete introduction]
PDF US $
- Single user / Non-Library usage: 44
- Multi user / Library usage: 176
Print-On-Demand (P.O.D): *215
Special Offer for Single user / Non-Library usage (PDF + P.O.D): *237

*(Excluding Mailing and Handling)
Purchase: Book Chapters
Download Flyers

Table of Contents

Preface , Pp. i-ii (2)

Allen B. Reitz and M. Iqbal Choudhary

Download Free

Contributors , Pp. vi-ix (2)

Atta-ur-Rahman, Allen B. Reitz and M. Iqbal Choudhary

Download Free

Always Around, Never the Same: Pathways of Amyloid Beta Induced Neurodegeneration Throughout the Pathogenic Cascade of Alzheimer , Pp. 1-14 (14)

Jeroen J.M. Hoozemans, Sidhartha M. Chafekar, Frank Baas, Piet Eikelenboom and Wiep Scheper

View Abstract Purchase Chapter

Novel Neuroprotective Therapies for Alzheimer's and Parkinsons's Disease , Pp. 15-57 (43)

Kirubakaran Shanmugam, Annette E.Maczurek, Megan L.Steele, Obdulio Benavente-García, Julian Castillo and Gerald Munch

View Abstract Download Free

Improving Memory: A Role for Phosphodiesterases , Pp. 58-80 (23)

Arjan Blokland1, Rudy Schreiber and Jos Prickaerts

View Abstract Purchase Chapter

Progress in Current Non-Viral Carriers for Gene Delivery , Pp. 81-97 (17)

Yoko Shoji-Moskowitz, Daisuke Asai, Ami E.Iskandrian, Kota Kodama, Yoshiki Katayama and Hideki Nakashima

View Abstract Purchase Chapter

Protein Transduction: Cell Penetrating Peptides and Their Therapeutic Applications , Pp. 98-126 (29)

Kylie M. Wagstaff and David A. Jans

View Abstract Purchase Chapter

Design of Peptide-Based Vaccines for Cancer , Pp. 127-166 (40)

Geoffrey A. Pietersz, Dodie S. Pouniotis and Vasso Apostolopoulos

View Abstract Download Free

Inhibitors of Protein: Geranylgeranyl Transferases , Pp. 167-233 (67)

Farid El Oualid, Gijs A. van der Marel and Mark Overhand

View Abstract Purchase Chapter

Voltage-Gated Sodium Channels: New Targets in Cancer Therapy? , Pp. 234-256 (23)

Ludovic Gillet, Sebastien Roger, Marie Potier, Lucie Brisson, Christophe Vandier, Pierre Besson and Jean-Yves Le Guennec

View Abstract Purchase Chapter

Recent Advances in Antiviral Agents: Antiviral Drug Discovery for Hepatitis Viruses , Pp. 257-271 (15)

Kyuichi Tanikawa

View Abstract Purchase Chapter

NO-Releasing Hybrids of Cardiovascular Drugs , Pp. 272-308 (37)

Alma Martelli, Simona Rapposelli, Maria C. Breschi and Vincenzo Calderone

View Abstract Purchase Chapter

Trends in the Development of New Drugs for Treatment of Benign Prostatic Hyperplasia , Pp. 309-349 (41)

Katarzyna Kulig and Barbara Malawska

View Abstract Purchase Chapter

Targeting the Prostaglandin D2 Receptors DP1 and CRTH2 for Treatment of Inflammation , Pp. 350-380 (31)

Trond Ulven and Evi Kostenis

View Abstract Purchase Chapter

Privileged Structures as Leads in Medicinal Chemistry , Pp. 381-422 (42)

Luca Costantino and Daniela Barlocco

View Abstract Purchase Chapter

Acetylcholinesterase Reprised: Molecular Modeling with the Whole Toolkit , Pp. 423-456 (34)

Gerald H. Lushington, Jian-Xin Guo and Margaret M. Hurley

View Abstract Purchase Chapter

Preface

This 5th volume of the book series “Frontiers in Medicinal Chemistry” consists of a compendium of useful reviews on topics of wide interest to researchers in the fields of Medicinal Chemistry, Drug Discovery and Chemical Biology. The contributions are separated into different therapeutic areas, along with two reviews on general enabling technologies. The objective of “Frontiers in Medicinal Chemistry” is to periodically publish collections of comprehensive overviews based on areas of topical interest, written by leading experts in their respective fields. Initial versions of these reviews have been published in the journals Current Medicinal Chemistry, Current Topics in Medicinal Chemistry, and Current Pharmaceutical Design, and the authors have had the opportunity to update their original manuscripts prior to publication in the current volume.

The initial section of this volume entails three reviews in the area of Central Nervous System therapeutics. The first by Scheper et al. summarizes current understanding on the role of the β-amyloid peptides in Alzheimer's disease. The second by Münch and colleagues entails neuroprotection for both Alzheimer’s and Parkinson’s diseases, and the third by Blokland et al. is on the topic of phosphodiesterase inhibition to improve cognition.

The Biologics section is next, containing reviews by Shoji-Moskowitz et al. on non-viral approaches for gene therapy, Jans and Wagstaff on peptides that can cross a membrane barrier, and Apostolopoulos and co-workers on peptidic vaccines for cancer.

The next section has two reviews in the area of Oncology. The first by Overhand et al. deals with geranylgeranyl transferases, the second by Besson el al. focuses on voltage-gated sodium channels as targets for cancer.

There are then four reviews that follow covering separate therapeutic areas. The first is a contribution in the area of Infectious Disease by Tanikawa on hepatitis B and C, Cardiovascular Diseases by Calderon et al. on nitric oxide releasing drugs, Endocrinology covering benign prostatic hypertrophy by Malawska and Kulig, and Inflammation on prostaglandin D2 receptor modulators by Ulven and Kostenis.

Finally, topics in the last section on Enabling Technologies include the concept of privileged structures in medicinal chemistry by Costantino and Barlocco, and the use of molecular modeling with application to acetylcholinesterase by Lushington et al.

We hope that Frontiers in Medicinal Chemistry becomes an invaluable resource for the benefit of researchers in various aspects of therapeutic drug discovery. We wish to thank the authors who have contributed to this volume, and Mahmood Alam, Samina Khan, Qurat-ul-Ain and Matthew Honan of Bentham Science Publishers for their efforts.

ALLEN B. REITZ
Johnson & Johnson
USA

ATTA-UR-RAHMAN
Higher Education Commission
International Center for Chemical Sciences
Pakistan

M. IQBAL CHOUDHARY
International Center for Chemical Sciences
Pakistan

List of Contributors

Co-Editor(s):
Atta-ur-Rahman
Biological Sciences
(HEJ Research Institute of Chemistry, Dr. Panjwani Center for Molecular, Medicine & Drug Research)
University of Karachi
Karachi, 75270
Pakistan


Allen B. Reitz
Johnson & Johnson Pharmaceutical Research and Development, Spring House
Pennsylvania , 19477
USA


M. Iqbal Choudhary
Biological Sciences
(HEJ Research Institute of Chemistry, Dr. Panjwani Center for Molecular, Medicine & Drug Research)
University of Karachi
Karachi, 75270
Pakistan




Editorial Advisory Board:
P.R. Bernstein
University of Delaware
Newark
DE
USA


C. Bor-Luen
National Taiwan University, Taipei
Taiwan
R.O.C.


R. Efremov
M.M. Shemyakin & Yu.A. Ovchinnikov Institute of Bioorganic Chemistry
Moscow
Russia


C. Garcia-Echeverria
Sanofi-Aventis
Paris
France


D. Hadjipavlou-Litina
Arristotle Universith of Thessaloniki
Thessaloniki
Greece


D. Heymann
University of Nantes
Nantes
France


D.A. Jans
Nuclear Signaling Laboratory, Monash University
Australia


G.B. Mahady
University of Illinois at Chicago
Chicago
IL
USA


B. Malawska
Jagiellonian University Collegium Medicum
Kraków
Poland


C. Philippe
Sciences and Technologies University of Lille
Lille
France




Contributor(s):
Jeroen J.M. Hoozemans
Neurogenetics Laboratory
Amsterdam
The Netherlands


Sidhartha M. Chafekar
Neurogenetics Laboratory
Amsterdam
The Netherlands


Frank Baas
Neurogenetics Laboratory, Department of Neurology
Academic Medical Center, University of Amsterdam
Amsterdam
The Netherlands


Piet Eikelenboom
Department of Neurology, Academic Medical Center
University of Amsterdam
Amsterdam
The Netherlands


Wiep Scheper
Neurogenetics Laboratory
Amsterdam
The Netherlands


Kirubakaran Shanmugam
Department of Pharmacology
School of Medicine, University of Western Sydney
Campbelltown
Australia


Annette E. Maczurek
Department of Pharmacology
School of Medicine, University of Western Sydney
Campbelltown
Australia


Megan L. Steele
Department of Pharmacology
School of Medicine, University of Western Sydney
Campbelltown
Australia


Obdulio Benavente-García
Furfural Español-Nutrafur
Alcantarilla
Murcia
Spain


Julián Castillo
Furfural Español-Nutrafur
Alcantarilla
Murcia
Spain


Gerald Münch
Department of Pharmacology,
School of Medicine, University of Western Sydney
Campbelltown
Australia


Arjan Blokland
Department of Psychology and Neuroscience
EURON, Maastricht University
P.O. Box 616
Maastricht
MD , 6200
The Netherlands


Rudy Schreiber
Sepracor, Inc.
84 Waterford Drive
Marlborough
MA, 01752
USA


Jos Prickaerts
Department of Psychiatry and Neuropsychology
Brain & Behavior Institute, EURON, Maastricht University
P.O. Box 616
Maastricht
MD , 6200
The Netherlands


Yoko Shoji-Moskowitz
CREST, JAPAN;FOLIGO Therapeutics, Inc.
USA


Daisuke Asai
CREST, JAPAN; Department of Microbiology, Department of Biomedical Engineering
St. Marianna University School of Medicine, Japan
Duke University
USA


Kota Kodama
CREST, JAPAN;FOLIGO Therapeutics, Inc.
Creative Research Institution
Hokkaido University
USA


Yoshiki Katayama
CREST, JAPAN; Department of Applied Chemistry
Faculty of Engineering, Kyushu University
Japan


Hideki Nakashima
CREST, JAPAN; Department of Applied Chemistry
Faculty of Engineering, Kyushu University
Japan


Kylie M. Wagstaff
Nuclear Signalling Laboratory, Department of Biochemistry and Molecular Biology
Monash University
Clayton
Australia


David A. Jans
ARC Centre of Excellence for Biotechnology and Development
Australia


Geoffrey A. Pietersz
Bio-organic and Medicinal Chemistry Laboratory
Australia


Dodie S. Pouniotis
Immunology and Vaccine Laboratory
Centre for Immunology, Burnet Institute
Commercial Road, Melbourne
Szeged
VIC, 3004
Australia


Vasso Apostolopoulos
Immunology and Vaccine Laboratory
Centre for Immunology, Burnet Institute
Commercial Road, Melbourne
Szeged
VIC, 3004
Australia


Farid El Oualid
Netherlands Cancer Institute
Division of Cell Biology
Amsterdam
1066 , CX
The Netherlands


Gijs A. van der Marel
Leiden Institute of Chemistry, Gorlaeus Laboratories
Leiden University
P.O. Box 9502
Leiden
RA, 2300
The Netherlands


Mark Overhand
Leiden Institute of Chemistry, Gorlaeus Laboratories
Leiden University
P.O. Box 9502
Leiden
RA, 2300
The Netherlands


Ludovic Gillet
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Sébastien Roger
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Marie Potier
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Lucie Brisson
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Christophe Vandier
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Pierre Besson
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Jean-Yves Le Guennec
U921 Inserm, Nutrition Croissance Cancer
Université de Tours; Faculté de Médecine
10 Bd Tonnellé
TOURS , 37032
France


Kyuichi Tanikawa
President, International Institute for Liver Research
Kurume University, Alley II 202
Tsubuku-honmachi 636-1
Kurume , 830-0047
Japan


Alma Martelli
Dipartimento di Psichiatria, Neurobiologia
Farmacologia e Biotecnologie,Università degli Studi di Pisa
Via Bonanno, 6
Pisa, I-56126
Italy


Simona Rapposelli
Dipartimento di Scienze Farmaceutiche
Università degli Studi di Pisa,Via Bonanno, 6
Av. de l'Hôpital, 1, B36
Pisa, I-56126
Italy


Maria C. Breschi
Dipartimento di Psichiatria, Neurobiologia
Farmacologia e Biotecnologie,Università degli Studi di Pisa
Via Bonanno, 6
Pisa, I-56126
Italy


Vincenzo Calderone
Dipartimento di Psichiatria, Neurobiologia
Farmacologia e Biotecnologie,Università degli Studi di Pisa
Via Bonanno, 6
Pisa, I-56126
Italy


Katarzyna Kulig
Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry
Jagiellonian University Medical College
Medyczna 9 str.
Kraków
FL, 30-688
Poland


Barbara Malawska
Department of Physicochemical Drug Analysis, Chair of Pharmaceutical Chemistry
Jagiellonian University Medical College
Medyczna 9 str.
Kraków
FL, 30-688
Poland


Trond Ulven
Department of Physics and Chemistry
University of Southern Denmark
Campusvej 55, DK-5230 Odense M
Denmark


Evi Kostenis
Institute for Pharmaceutical Biology, University of Bonn
Nussallee 6, PO Box 100485
Bonn, 53115
Germany


Luca Costantino
Dipartimento di Scienze Farmaceutiche, Via Campi 183
University of Modena e Reggio Emilia
Modena, 41100
Italy


Daniela Barloccob
Dipartimento di Scienze Farmaceutiche “Pietro Pratesi”
Via L. Mangiagalli 25, University of Milano
Milano, 20133
Italy


Gerald H. Lushington
Molecular Graphics and Modeling Laboratory
University of Kansas
Lawrence
KS , 66045
USA


Jian-Xin Guo
Molecular Graphics and Modeling Laboratory
University of Kansas
Lawrence
KS , 66045
USA


Margaret M. Hurley
Weapons and Materials Research Directorate
U.S. Army Research Laboratory
Aberdeen Proving Ground
MD , 21005
USA




Advertisement


Webmaster Contact: urooj@benthamscience.org Copyright © 2014 Bentham Science