Pregnancy Disorders and Perinatal Outcomes


by

Julie Lafond

DOI: 10.2174/97816080537281120101
eISBN: 978-1-60805-372-8, 2012
ISBN: 978-1-60805-501-2



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Indexed in: Book Citation Index, Science (BKCI-S), Web of Science, Scopus

Pregnancy Disorders and Perinatal Outcomes offers readers insights into knowledge related to maternal habits or disor...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Thierry Lacaze-Masmonteil

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Preface

- Pp. ii

Cathy Vaillancourt and Julie Lafond

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List of Contributors

- Pp. iii-vi (4)

Julie Lafond and Cathy Vaillancourt

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Introduction

- Pp. vii

Julie Lafond and Cathy Vaillancourt

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Embryo Implantation Disorders

- Pp. 3-19 (17)

Mohan Singh, Parvesh Chaudhry and Eric Asselin

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The Impact of Assisted Reproductive Technologies on Perinatal Outcomes

- Pp. 20-34 (15)

Patricia Monnier, Maria del Pilar Vélez and Thierry Forges

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Human Placentation and Maternal Adaptation to Pregnancy: The Role of Trophoblast

- Pp. 35-57 (23)

Thierry Fournier, Vassilis Tsatsaris, André Malassiné and Danièle Evain-Brion

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Biochemical Markers of Hypertensive Disorders of Pregnancy

- Pp. 58-73 (16)

Yves Giguère, Marc Charland, Dominique Guérette, Joël Girouard, François Rousseau and Jean-Claude Forest

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Immune System and Perinatal Outcomes

- Pp. 74-87 (14)

Shigeru Saito

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Gestational Diabetes Affects Placental-Fetal Development

- Pp. 88-96 (9)

Evemie Dubé, Cathy Vaillancourt, Julie Lafond and Louiza Belkacemi

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Placental Disorders in Preeclampsia: Maternal and Perinatal Outcomes

- Pp. 97-128 (32)

Dave Lanoix, Sophie Haché, Evemie Dubé, Julie Lafond and Cathy Vaillancourt

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Epigenetic Regulation of Pregnancy Outcome

- Pp. 129-148 (20)

Jeffrey M. Craig, Ji-Hoon Eric Joo, Boris Novakovic and Richard Saffery

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Subject Index

- Pp. 149-152 (4)

Julie Lafond and Cathy Vaillancourt

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Foreword

When Drs. Vaillancourt and Lafond asked me to write this foreword, I was honored to have the opportunity to introduce this eBook.

Despite the improvements in perinatal and neonatal outcomes with the progress in diagnostic, health care and service and treatment, the perinatal morbidity and mortality observed in conjunction with adverse pregnancy outcomes particularly in the developing countries remain an important health problem. A recent study of the American Health Institute suggests that half of all fetal deaths were caused by a complication during pregnancy. Specifically, a placental dysfunction was the cause in 26% of all fetal deaths, infections in the mother were the causes in 14-19% of cases, while in only 10% of cases, fetal malformations or umbilical cord dysfunctions were the cause. This study suggests that any disturbance during pregnancy including the state of the intrauterine environment during critical periods of organogenesis and fetal growth can permanently modify fetal programming; altering the organ structure and work in an epigenetic way.

In tracking healthy pregnancies through research, immense progress was made in understanding the types of disturbances and complications occur in pregnancy. This ongoing research helps to find innovative ways of minimizing these disturbances and complications, dealing with them when they do occur, ultimately leading to healthy pregnancies and healthier infants.

This eBook, while very comprehensive, remains simple in its approach. It aims at providing readers with an update on the current research on pregnancy disorders that affect fetal development and could lead to disability later in childhood and adulthood. The eBook is very well organized in eight chapters written by experts working in the burgeoning area of integrative physiology that attempts to unite nature and nurture.

In conclusion, I am excited about this eBook, not only because of its superbly organized, illustrated and presented content, but also because I anticipate that it will be useful to all those who have an interest in unraveling the mysteries of life. I believe that better management of pregnancy in the present will have long term wide-scale effects on the global health in our society.

Thierry Lacaze-Masmonteil, MD, PhD, FRCPC
Professor of Pediatrics, University of Ottawa
Regional Medical Lead-Newborn (Champlain Maternal Newborn Regional Program)
Neonatology, Division Head: CHEO-the Ottawa Hospital
Children's Hospital of Eastern Ontario
401 Smyth Road, Ottawa, ON, Canada, K1H 8L1


Preface

Adverse pregnancy outcomes are on the rise world-wide, leading to increased perinatal morbidity and mortality. Moreover, pregnancy disorders can lead to disruption in fetal programming. The fetal programming hypothesis suggests that the intrauterine environment during critical periods of organogenesis and tissue growth may permanently alter organ structure and function in an epigenetic manner. Accompanied with this are immense economic and emotional costs. In the course of its research on healthy pregnancy, scientists have made great progress in understanding features of disorders that may occur during pregnancy. These ongoing investigations are important to find ways to treat and prevent these disorders to support women in having healthy pregnancies and babies.

Since 1989, when David Barker showed an inverse relationship between birth weight and mortality due to adult ischemic heart disease, the role of prenatal programming, and by consequence pregnancy disorder, as a determinant of adult diseases has become increasingly clear. While epidemiological evidence for the role of early developmental growth patterns leading to specific adult disease outcomes has continued to strengthen, experimental evidence from animal models has brought new and compelling support for this important determinant of health throughout lifetime.

This eBook aims at providing readers with the latest research on the current state of knowledge related to pregnancy disorders that affect fetal development and possibly fetal programming. This eBook contains eight reviews by experts who are working in this burgeoning area of integrative physiology is an attempts to unite nature and nurture. We trust it to be useful to all of those who have an interest in unraveling the mysteries of life. We believe that better management of pregnancy today will have long term and wide-scale effects on the health of our society.

Cathy Vaillancourt
INRS-Institut Armand Frappier
Université du Québec
Canada

Julie Lafond
BioMed Research Centre
Department of Sciences Biologiques
Université du Québec à Montréal
Canada

List of Contributors

Editor(s):
Julie Lafond
Université du Québec à Montréal
Canada
/
INRS-Institut Armand-Frappier
Canada




Contributor(s):
Eric Asselin
Research Group in Molecular Oncology and Endocrinology
Canada research chair in molecular gyneco-oncology
Department of Chemistry-Biology
University of Quebec at Trois-Rivières
Trois-Rivières
QC
Canada


Louiza Belkacemi
Perinatal Research Laboratories Department of Obstetrics and Gynecology
David Geffen School of Medicine
University of California Los Angeles
Los Angeles Biomedical Research Institute
Harbor-UCLA Medical Center
Torrance
California
USA


Marc Charland
Reproduction, Perinatal Health and Child Health Research Axis
CHUQ Research Center
Québec City
QC
Canada


Parvesh Chaudhry
Department of Chemistry-Biology
Research Group in Molecular Oncology and Endocrinology
University of Quebec at Trois-Rivières
Trois-Rivières
QC
Canada


Jeffrey M. Craig
Early Life Epigenetics
Murdoch Childrens Research Institute
Royal Children’s Hospital
Department of Paediatrics
University of Melbourne
Melbourne
Victoria
Australia


Maria del Pilar Vélez
Obstetrics and Gynecology Department
University of Montreal
Montreal
Quebec
Canada


Evemie Dubé
BioMed Research Centre
Department of Sciences Biologiques
Université du Québec à Montréal
Montreal
QC
Canada


Danièle Evain-Brion
Unité Mixte de Recherches-Santé UMR-S 767
Institut National de la Santé et de la Recherche Médicale (INSERM), Paris Descartes University
PremUP Foundation
Faculty of Pharmaceutical and Biological Sciences
Paris, F-75006
France


Jean-Claude Forest
Reproduction, Perinatal Health and Child Health Research Axis
CHUQ Research Center
Department of Molecular Biology
Medical Biochemistry and Pathology
Faculty of Medicine, Université Laval
Québec City
QC
Canada


Thierry Forges
Department of Reproductive Medicine
Maternité Universitaire
10 rue Dr Heydenreich
Nancy, 54042
France


Thierry Fournier
Unité Mixte de Recherches-Santé UMR-S 767
Institut National de la Santé et de la Recherche Médicale (INSERM) and Paris Descartes University
PremUP Foundation
Faculty of Pharmaceutical and Biological Sciences
Paris, F-75006
France


Yves Giguère
Reproduction, Perinatal Health and Child Health Research Axis
CHUQ Research Center
Department of Molecular Biology
Medical Biochemistry and Pathology
Faculty of Medicine, Université Laval
Québec City
QC
Canada


Joël Girouard
Reproduction, Perinatal Health and Child Health Research Axis
CHUQ Research Center
Québec City
QC
Canada


Dominique Guérette
Reproduction, Perinatal Health and Child Health Research Axis
CHUQ Research Center
Québec City
QC
Canada


Sophie Haché
Department of Sciences Biologiques
BioMed Research Centre
Université du Québec à Montréal
Montreal
QC
Canada


Ji-Hoon Eric Joo
Early Life Epigenetics
Murdoch Childrens Research Institute
Royal Children’s Hospital
Department of Paediatrics
University of Melbourne
Melbourne
Victoria
Australia


Julie Lafond
Department of Sciences Biologiques
BioMed Research Centre
Université du Québec à Montréal
Montreal
QC
Canada


Dave Lanoix
INRS-Institut Armand-Frappier
Université du Québec
531 blvd. des Prairies
Laval
QC
Canada


André Malassiné
Unité Mixte de Recherches-Santé UMR-S 767
Institut National de la Santé et de la Recherche Médicale (INSERM) and Paris Descartes University
PremUP Foundation
Faculty of Pharmaceutical and Biological Sciences
Paris, F-75006
France


Patricia Monnier
Department of Obstetrics and Gynecology
McGill Reproductive Centre
Division of Reproductive Endocrinology and Infertility
McGill University, Royal Victoria Hospital
Montreal
Quebec
Canada


Boris Novakovic
Cancer, Disease and Developmental Epigenetics
Murdoch Childrens Research Institute
Royal Children’s Hospital
Department of Paediatrics
University of Melbourne
Melbourne
Victoria
Australia


François Rousseau
Reproduction, Perinatal Health and Child Health Research Axis
CHUQ Research Center
Department of Molecular Biology
Medical Biochemistry and Pathology
Faculty of Medicine, Université Laval
Québec City
QC
Canada


Richard Saffery
Cancer, Disease and Developmental Epigenetics
Murdoch Childrens Research Institute
Royal Children’s Hospital
Department of Paediatrics
University of Melbourne
Melbourne
Victoria
Australia


Shigeru Saito
Department of Obstetrics and Gynecology
2630 Sugitani Toyama-shi
Toyama
Japan


Mohan Sran
Department of Chemistry-Biology
Research Group in Molecular Oncology and Endocrinology
University of Quebec at Trois-Rivières
Trois-Rivières
QC
Canada


Vassilis Tsatsaris
Assistance Publique-Hôpitaux de Paris
Centre Hospitalier Universitaire Cochin and Maternité Port-Royal
Paris, F-75014
France


Cathy Vaillancourt
INRS-Institut Armand-Frappier
Université du Québec
531 blvd. des Prairies
Laval
QC
Canada




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