Surface Tailoring of Inorganic Materials for Biomedical Applications


by

Lia Rimondini

DOI: 10.2174/97816080546261120101
eISBN: 978-1-60805-462-6, 2012
ISBN: 978-1-60805-556-2

  
  




Inorganic materials have been used for biomedical applications since many decades. They have been utilized successfully because of eas...[view complete introduction]
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Table of Contents

Foreword , Pp. i-ii (2)

Luigi Ambrosio
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Preface , Pp. iii

Lia Rimondini, Claudia L. Bianchi and Enrica Vernè
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List of Contributors , Pp. iv-vii (4)

Lia Rimondini, Claudia L. Bianchi and Enrica Vernè
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Physico-Chemical Tailoring of Material Surface Properties , Pp. 3-42 (40)

S. Ardizzone, I. Biraghi, G. Cappelletti, D. Meroni and F. Spadavecchia
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Calcium Phosphate Surface Tailoring Technologies for Drug Delivering and Tissue Engineering , Pp. 43-111 (69)

Christophe Drouet, Jaime Gomez-Morales, Michele Iafisco and Stephanie Sarda
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Sonochemically Synthesized Materials for Biomedical Applications , Pp. 112-129 (18)

Muthupandian Ashokkumar
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Vibrational Spectroscopies for Surface Characterization of Biomaterials , Pp. 130-152 (23)

José Manuel Delgado-López, Jaime Gómez-Morales and Michele Iafisco
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Surface Characterization of Inorganic Nanobiomaterials at a Molecular Scale: Use of Vibrational Spectroscopies , Pp. 153-172 (20)

Gianmario Martra, Valentina Aina, Yuriy Sakhno, Luca Bertinetti and Claudio Morterra
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Morphological Surface Characterization of Nano-Structured Inorganic and Polymeric Materials for Biomedical Application , Pp. 173-206 (34)

Barbara Palazzo, Ismaela Foltran and Dominic Walsh
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Biological Characterization of Biomaterials: In vitro Tests , Pp. 207-223 (17)

Neelam Gurav, Borvornwut Buranawat and Lucy Di Silvio
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Biological Characterization of the Materials: In Vivo Tests , Pp. 224-246 (23)

Roberto Giardino, Milena Fini, Nicolò Nicoli Aldini and Anna Paola Parrilli
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New Concepts Applied to the Development of Biomaterials for Orthopaedic Tissue Regeneration , Pp. 247-278 (32)

Anna Tampieri and Simone Sprio
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Metallic Surfaces for Osteointegration , Pp. 279-296 (18)

Silvia Spriano and Sara Ferraris
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Tailoring of Tissue-Surface Interaction in Blood Contacting Materials , Pp. 297-327 (31)

Roman Major and Boguslaw Major
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Tailoring Surfaces of Nanocarriers for Cancer Therapy and Diagnosis , Pp. 328-345 (18)

Gürer G. Budak, Tolga Çamli, Fatih Büyükserin and Selman Yavuz
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Drug Delivery from Ordered Mesoporous Matrices for Bone Tissue Engineering , Pp. 346-358 (13)

Renato Mortera and Barbara Onida
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Methods to Study the Mechanism of Bioactivity , Pp. 359-375 (17)

Antonio J. Salinas and María Vallet-Regí
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New Trends in Bone Tissue Engineering Scaffolds: Hierarchically Porous Glass and Glass-Ceramic Structures , Pp. 376-391 (16)

Francesco Baino and Chiara Vitale Brovarone
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Surface Modification of Bioactive Glasses , Pp. 392-405 (14)

Sara Ferraris and Marta Miola
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Index , Pp. 406-412 (7)

Lia Rimondini, Claudia Bianchi and Enrica Vernè
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Foreword

Biomaterials, the functional components of medical devices, are used extensively in the treatment of disease, trauma and disability. The history of biomaterials began in the pre-Christian era, with the use copper, bronze, precious stones or shells and natural fiber to substitute parts of the human body. Since then, many improvements have been implemented in medical device manufacturing, through the advent of new biomaterials and innovative design and characterization techniques.

Some of the most significant advances have taken place in the last 50 years, a period which has witnessed the introduction of pioneering joint and heart valve replacements and, more recently, the development of so-called bioactive materials which interact with the host tissues to assist healing. While these advances have been arguably sufficient to meet the medical challenges of the last century, society now faces even greater problems. These are caused mainly by an increase in lifespan which is frequently not matched by maintenance of health and quality of life.

The ability to tailor the surface of inorganic biomaterials introduces the possibility to broaden their area of application to include, for example, bioactive prostheses, biomimetic scaffolds for tissue engineering, and systems for drug delivery.

The implementation of nanotechnology has offered a completely new perspective to material scientists aiming to mimic the different types of extracellular matrices present in tissues. Techniques are now available which can produce structures on the nanometer scale which exhibit finely controlled atomic composition and architecture.

This eBook provides an interdisciplinary overview of the surface treatment of a wide range of nano- and micro-structured inorganic materials, both degradable and non-degradable, for a wide range of clinical and biomedical applications.

Luigi Ambrosio
Institute of Composite & Biomedical Materials (IMCB-CNR)
National Research Council of Italy
Piazzale F. Tecchio 80
80125 Naples, Italy
Tel.: +39-0812425929
Fax: +39-0812425932
Email: ambrosio@unina.it

Director of IMCB-CNR
President of the European Society for Biomaterials
Adjunct Professor of Artificial Organs at University of Naples Federico II


Preface

Biomaterial surfaces play a crucial role in medicine and biology, since most of the biological reactions occurring in vivo take place at surfaces and interfaces. As an example, when biomaterials are implanted, protein adsorption on the foreign surface occurs immediately. In protein-surface interactions a variety of governing factors have to be considered in defining the role of the solid-solution interface. Among them, surface charge, surface roughness, absorbed ions, surface composition, surface energy etc., are determined by the physical state of the material.

In the last decades, the ability of scientists to investigate the composition and molecular structure of biomaterials surface has significantly increased, due to the evolution of the characterization techniques. Similar advancements have occurred in molecular biology and material science.

These advancements allowed the development of a biological model for surface science, aiming to understand how the biological behavior of a material can be controlled by its surface properties.

In this eBook, a number of examples of surface tailoring studies on different class of biomaterials are presented, offering a wide range state-of-the-art of biomedical surface science taking into account also the clinical applications.

The chapters of this eBook written by eminent scientists, everyone specialized in their own field, will serve as an important and useful reference source for biomedical engineers and biologists.

Lia Rimondini
Università del Piemonte Orientale “Amedeo Avogadro”, Novara
Italy

Claudia L. Bianchi
Università degli Studi di Milano, Milano
Italy

Enrica Vernè
Politecnico di Torino, Torino
Italy

List of Contributors

Editor(s):
Lia Rimondini
Università del Piemonte Orientale “Amedeo Avogadro”
Italy




Co-Editor(s):
Claudia L. Bianchi
Università degli Studi di Milano
Italy


Enrica Vernè
Politecnico di Torino
Italy




Contributor(s):
Valentina Aina
Dipartimento di Chimica IFM & Interdipartimental Centre of Excellence
“Nanostructured Interfaces and Surfaces - NIS”
Universita’ di Torino
Torino
Italy


Silvia Ardizzone
Dipartimento di Chimica Fisica ed Elettrochimica
Università di Milano
Milano
Italy


Muthupandian Ashokkumar
School of Chemistry, University of Melbourne
Parkville
VIC, 3010
Australia


Nicolò Nicoli Aldini
Preclinical and Surgical Studies Laboratory - Rizzoli Orthopaedic Institute
Codivilla Putti Research Institute
Bologna
Italy


Luca Bertinetti
Dipartimento di Chimica IFM & Interdipartimental Centre of Excellence
“Nanostructured Interfaces and Surfaces - NIS”
Università di Torino
Torino
Italy


Borvornwut Buranawat
King's College London, Biomaterials, Biomimetics & Biophotonics Group, Dental Insitute, at Guy's
King's College and St Thomas' Hospitals
UK


Fatih Büyükserin
Gazi University NanoMedicine & Advance Technology Research Center
Ankara
Turkey


Francesco Baino
Dipartimento di Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino
Torino
Italy


Gürer G. Budak
Gazi University NanoMedicine & Advance Technology Research Center
Ankara
Turkey


Iolanda Biraghi
Dipartimento di Chimica Fisica ed Elettrochimica
Università di Milano
Milano
Italy


Chiara Vitale Brovarone
Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino
Torino
Italy


Giuseppe Cappelletti
Dipartimento di Chimica Fisica ed Elettrochimica
Università di Milano
Milano
Italy


Tolga Çamli
Gazi University NanoMedicine & Advance Technology Research Center
Ankara
Turkey


Christophe Drouet
Université de Toulouse, Institut Carnot CIRIMAT
UPS - INPT - CNRS, ENSIACET
Toulouse
France


José Manuel Delgado - López
LEC, IACT (CSIC - UGR). Ed. Instituto López Neyra
University ogf Granada
Spain


Lucy Di Silvio
King's College London, Biomaterials, Biomimetics & Biophotonics Group
, Dental Insitute, at Guy's, King's College and St Thomas' Hospitals
UK


Sara Ferraris
Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino
Torino
Italy


Milena Fini
Preclinical and Surgical Studies Laboratory
Rizzoli Orthopaedic Institute, Codivilla Putti Research Institute
Bologna
Italy


Ismaela Foltran
Dipartimento di Chimica ‘‘G. Ciamician’’, Alma Mater Studiorum
Università di Bologna Bologna; Dipartimento di Scienze della Salute
Italy


Roberto Giardino
Preclinical and Surgical Studies Laboratory
Rizzoli Orthopaedic Institute, Codivilla Putti Research Institute
University of Bologna Medical School
Bologna
Italy


Jaime Gomez - Morales
Laboratorio de Estudios Cristalograficos
IACT (CSIC - UGR) University of Granada
Spain


Neelam Gurav
King's College London, Biomaterials, Biomimetics & Biophotonics Group
Dental Insitute, at Guy's, King's College and St Thomas' Hospitals
UK


Michele Iafisco
Dipartimento di Chimica ‘‘G. Ciamician’’, Alma Mater Studiorum
Università di Bologna, Bologna, Italy; Dipartimento di Scienze della Salute
Novara
Italy


Boguslaw Major
Institute of Metallurgy and Materials Science Polish Academy of Sciences
Krakow
Poland


Roman Major
Institute of Metallurgy and Materials Science Polish Academy of Sciences
Krakow
Poland


Gianmario Martra
Dipartimento di Chimica IFM & Interdipartimental Centre of Excellence
“Nanostructured Interfaces and Surfaces - NIS”
Torino
Italy


Daniela Meroni
Dipartimento di Chimica Fisica ed Elettrochimica
Università di Milano
Milano
Italy


Marta Miola
Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino, Politecnico di Torino
Torino
Italy


Renato Mortera
Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino
Torino
Italy


Barbara Onida
Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino
Torino
Italy


Barbara Palazzo
Ghimas S.p.A., Cittadella della Ricerca Brindisi
Dipartimento di Scienze della Salute
Università del Pimeonte Orientale
Novara
Italy


Anna Paola Parrilli
Preclinical and Surgical Studies Laboratory
Rizzoli Orthopaedic Institute, Codivilla Putti Research Institute
Bologna
Italy


Yuriy Sakhno
Dipartimento di Chimica IFM & Interdipartimental Centre of Excellence
“Nanostructured Interfaces and Surfaces - NIS”
University of Torino
Torino
Italy


Antonio J. Salinas
Departamento de Química Inorgánica y Bioinorgánica, Facultad Farmacia
Universidad Complutense; Madrid, Centro de Investigación Biomédica en Red
Bioingeniería, Biomateriales y Nanomedicina
CIBER - BBN
Spain


Stephanie Sarda
Institut Carnot CIRIMAT, UPS - INPT - CNRS
ENSIACET, Université de Toulouse
France


Francesca Spadavecchia
Dipartimento di Chimica Fisica ed Elettrochimica
Università di Milano
Milano
Italy


Silvia Spriano
Dipartimento di Scienza Applicata e Tecnologia
Politecnico di Torino, Politecnico di Torino
Torino
Italy


Simone Sprio
Italian National Research Council
Institute for Science and Technology for Ceramics
ISTEC - CNR
Faenza
Italy


Anna Tampieri
Italian National Research Council
Institute for Science and Technology for Ceramics
ISTEC - CNR
Faenza
Italy


Selman Yavuz
Gazi University NanoMedicine & Advance Technology Research Center
Ankara
Turkey


María Vallet-Regí
Departamento de Química Inorgánica y Bioinorgánica
Facultad Farmacia; Universidad Complutense; Madrid
Centro de Investigación Biomédica en Red: Bioingeniería
Biomateriales y Nanomedicina
CIBER - BBN
Spain


Dominic Walsh
School of Chemistry, University of Bristol
Bristol
UK




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