Advances in Cancer Drug Targets

Volume 1

by

Atta-ur-Rahman

DOI: 10.2174/97816080547561130101
eISBN: 978-1-60805-474-9, 2013
ISBN: 978-1-60805-601-9
ISSN: 2213-9915

  
  




Advances in Cancer Drug Targets is an e-book series that brings together recent...[view complete introduction]
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Table of Contents

Foreword , Pp. i- (1)

Atta-ur-Rahman

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List of Contributors , Pp. ii-v (4)

Atta-ur-Rahman

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The PIK3CA Gene as a Mutated Target for Cancer Therapy , Pp. 3-21 (19)

Sarah Croessmann, Justin Cidado, John P. Gustin, David Cosgrove and Ben Ho Park

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AKT Signaling in Regulating Angiogenesis , Pp. 22-50 (29)

Bing-Hua Jiang and Ling-Zhi Liu

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Inhibitors of Cyclin Dependent Kinases: Useful Targets for Cancer Treatment (An Update) , Pp. 51-119 (69)

P. Sapra Sharma and R. Sharma

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Cellular FLICE-Like Inhibitory Protein (c-FLIP): A Key Anti- Apoptotic Factor and a Target for Cancer Therapy , Pp. 120-145 (26)

Ahmad R. Safa

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Pin1: A Promising Novel Diagnostic and Therapeutic Target that Acts on Numerous Cancer-Driving Pathways , Pp. 146-171 (26)

Greg Finn, Man-Li Luo, Xiao Zhen Zhou and Kun Ping Lu

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Anticancer Immunotherapy in Combination with Proapoptotic Therapy - Possible Therapeutic Strategies for Enhancement of Anticancer Immune Reactivity in Autologous Immunocompetent Cells and After Allogeneic Stem Cell Transplantation , Pp. 172-206 (35)

Håkon Reikvam, Elisabeth Ersvær, Guro Kristin Melve, Astrid Olsnes Kittang, Bjørn Tore Gjertsen and Øystein Bruserud

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Melatonin and Breast Cancer: Selective Estrogen Enzyme Modulator Actions , Pp. 207-237 (31)

Samuel Cos, Alicia González, Virginia Alvarez-García, Carolina Alonso-González and Carlos Martínez-Campa

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Targeting Cancer and Neuropathy with Histone Deacetylase Inhibitors , Pp. 238-263 (26)

V. Rodriguez-Menendez, L. Tremolizzo and G. Cavaletti

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Index , Pp. 264-308 (45)

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Foreword

Cancer drug therapy has evolved significantly since the assumption made by Paul Ehrlich and others that low molecular weight compounds could be used to manage cancers and infectious diseases. Progress in the synthesis and isolation of organic compounds as well as our understanding of the structure and nature of DNA have also contributed to advances in anti-cancer drug development. Contemporary biochemical strategies to combat cancers range from cytotoxic and DNA damaging mechanisms to regulating programmed cell death (apoptosis). This e-book is the first volume of the series Advances in Cancer Drug Targets and is a compilation of recent expert reviews published on the subject with a focus these strategies. The reference work serves to give readers a brief yet comprehensive glance at current theory and practice behind employing chemical compounds for tackling tumor suppression, DNA site specific drug targeting and the inhibition of enzymes involved in growth control pathways. The reviews, written by experts in pharmaceutical sciences and molecular biology, have been carefully selected and represent an attempt to collect and present research on anti-cancer drug development in a separate volume for interested researchers and pharmaceutical scientists. Advances in Cancer Drug Targets can also provide insights into development of new approaches to anti-cancer therapy. I hope that the articles contained in this volume will be greatly enjoyed by the readers.

I would like to thank Mr. Mahmood Alam, Mr. Taimur Khan, Ms. Nazia Kamran and Ms. Humaira Hashmi for their help and support.

Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
Cambridge
UK


List of Contributors

Editor(s):
Atta-ur-Rahman
Honorary Life Fellow Kings College
University of Cambridge
Cambridge
UK




Contributor(s):
Carolina Alonso-González
Department of Physiology and Pharmacology
School of Medicine
University of Cantabria
Spain


Virginia Alvarez-García
Department of Physiology and Pharmacology
School of Medicine
University of Cantabria
Spain


Øystein Bruserud
Institute of Medicine
University of Bergen
Haukeland University Hospital
Norway


Guido Cavaletti
Department of Neuroscience and Biomedical Technologies
University of Milano-Bicocca
Italy


Justin Cidado
The Sidney Kimmel Comprehensive Cancer Center
School of Medicine
The Johns Hopkins University
USA


Samuel Cos
Department of Physiology and Pharmacology
School of Medicine
University of Cantabria
Spain


David Cosgrove
Division of Medical Oncology
The Johns Hopkins University
School of Medicine
USA


Sarah Croessmann
The Sidney Kimmel Comprehensive Cancer Center
School of Medicine
The Johns Hopkins University
USA


Elisabeth Ersvær
Institute of Medicine
University of Bergen
Norway


Greg Finn
Cancer Biology Program
Division of Hematology/Oncology
Department of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
USA


Bjørn Tore Gjertsen
Section for Hematology
Department of Medicine
Haukeland University Hospital
Norway


Alicia González
Department of Physiology and Pharmacology
School of Medicine
University of Cantabria
Spain


John P. Gustin
The Sidney Kimmel Comprehensive Cancer Center
School of Medicine
The Johns Hopkins University
USA


Bing-Hua Jiang
Department of Pathology
Anatomy and Cell Biology
Thomas Jefferson University
USA


Astrid Olsnes Kittang
Section for Hematology
Department of Medicine
Haukeland University Hospital
Norway


Ling-Zhi Liu
Department of Pathology
Anatomy and Cell Biology
Thomas Jefferson University
USA


Kun Ping Lu
Cancer Biology Program
Division of Hematology/Oncology
Department of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
USA


Man-Li Luo
Cancer Biology Program
Division of Hematology/Oncology
Department of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
USA


Carlos Martínez-Campa
Department of Physiology and Pharmacology
School of Medicine
University of Cantabria
Spain


Guro Kristinv Melve
Department of Immunology and Transfusion Medicine
Haukeland University Hospital
Norway


Ben Ho Park
Department of Oncology
The Sidney Kimmel Comprehensive Cancer Center
The Johns Hopkins University
USA


Håkon Reikvam
Institute of Medicine
University of Bergen
Haukeland University Hospital
Norway


Virginia Rodriguez-Menendez
Department of Neuroscience and Biomedical Technologies
University of Milano-Bicocca
Italy


Ahmad R. Safa
Department of Pharmacology and Toxicology
Indiana University Simon Cancer Center
Indiana University School of Medicine
USA


Pooja S. Sharma
Department of Chemistry
C.S.S.S. (P.G.) College
India


Rajan Sharma
Department of Chemistry
C.S.S.S. (P.G.) College
India


Lucio Tremolizzo
Department of Neuroscience and Biomedical Technologies
University of Milano-Bicocca
Italy


Xiao Zhen Zhou
Cancer Biology Program
Division of Hematology/Oncology
Department of Medicine
Beth Israel Deaconess Medical Center
Harvard Medical School
USA




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