Frontiers in Clinical Drug Research – Anti Allergy Agents

Volume 1

by

Atta-ur-Rahman

DOI: 10.2174/97816080571841130101
eISBN: 978-1-60805-718-4, 2013
ISBN: 978-1-60805-752-8
ISSN: 2214-6938

  
  




Frontiers in Clinical Drug Research - Anti-Allergy Agents is an exciting eBook ...[view complete introduction]
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Table of Contents

Preface , Pp. i-ii (2)

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List of Contributors , Pp. iii-vi (4)

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Topical Use of Calcineurin Inhibitors in Dermatology , Pp. 3-23 (21)

Sedef Bayata and Aylin Türel Ermertcan

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New Therapies for Asthma: What Else Besides Steroids? , Pp. 24-49 (26)

Jorge Sánchez and Javier Estarita

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Anti-Allergy Agents in Patients Practicing Sports , Pp. 50-117 (68)

Mariana Couto, Diana Silva, Luís Delgado and André Moreira

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Omalizumab Therapy for Allergic Diseases , Pp. 118-161 (44)

Juan Antonio Martinez-Tadeo, Eva Perez-Rodriguez and Zulay Almeida-Sanchez

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Therapeutics for Allergy Management , Pp. 162-181 (20)

Sagar Laxman Kale and Naveen Arora

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Main Food Allergic Therapies (Promising Ongoing Projects) , Pp. 182-239 (58)

Marina Pérez-Gordo, Carlos Pastor-Vargas and Bárbara Cases

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Vitamins in the Therapy of Inflammatory and Oxidative Diseases , Pp. 240-264 (25)

Neena Philips, Mathew Samuel, Harit Parakandi, Halyna Siomyk, Michael Re, Sesha Gopal, Hui Jia and Hossam Shahin

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A Novel Therapeutic Anti-allergy Approach: The Nontraditional Signaling Pathways of Adiponectin and Estrogen , Pp. 265-329 (65)

Jianli Zhao, Wayne Bond Lau and Yajing Wang

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Indications for Adrenaline: Use by Patients and Emergency Departments , Pp. 330-363 (34)

Miguel A. Tejedor-Alonso, Maria V. Mugica-Garcia and Mar Moro-Moro

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Index , Pp. 364-380 (17)

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Preface

Frontiers in Clinical Drug Research - Anti-Allergy Agents is an exciting eBook series comprising a selection of chapters relevant to the development of pharmacological agents used for the treatment of allergies. The contributions by leading researchers in the field shed light on new therapies for allergic reactions, nutrition based therapies and the use of substances such as omalizumab and adrenaline to counter inflammatory response and anaphylaxis in patients. The scope of the chapters includes clinical trials of anti-inflammatory and anti-allergic drugs, drug delivery strategies used to treat specific allergies (such as inflammation, asthma and dermatological allergies), lifestyle dependent modes of therapies and the immunological or metabolic mechanisms that are of interest to researchers as targets for new drugs.

In the first chapter, Sedef Bayata and Aylin Turel Ermertcan have discussed the mechanism of action, efficacy, safety, adverse effects of topical calcineurin inhibitors and their innovative use in dermatology. In chapter two, Jorge Sánchez and Javier Estarita present the biological agents available for the treatment of asthma and other allergic diseases such as omalizumab (Anti-IgE) and mepolizumab (Anti-IL5). The different monoclonal antibodies that are being studied in allergic disease with emphasis on the evidence of their use in asthma is also reviewed. Mariana Couto et al. demonstrate the hypersensitivity disorder problems for both recreational and competitive athletes such as asthma in the next chapter.

In chapter four Martinez-Tadeo et al. have discussed the use of omalizumab therapy for allergic diseases such as asthma of occupational origin, seasonal or perennial allergic rhinitis, and chronic urticaria. Sagar Laxman Kale and Naveen Arora provide a comprehensive overview of different therapeutic approaches for the management of allergic diseases which include allergen avoidance, pharmacotherapy and allergen specific immunotherapy (SIT) in chapter 5.

Food allergies have been increasing in prevalence over the last 10 years. In chapter six, Marina Pérez-Gordo et al. have discussed a number of promising emerging therapeutic modalities for food allergy, including allergen-specific and allergen non-specific immunotherapeutic approaches.

In chapter seven, Neena Philips et al. present the pathophysiology of several diseases, including allergy and asthma, which is linked to increased reactive oxygen or nitrogen species and inflammatory cytokines. They also discuss inflammatory and oxidative processes consisting of the breakdown of membrane lipids to generate important inflammatory mediators (prostaglandins, platelet activating factor) that activate immune cells, degranulate eosinophils, and mediate vascular alterations.

Jianli Zhao have reviewed the recent developments regarding adiponectin and estrogen in the context of allergic pathology, encompassing asthma, allergic rhinitis, and immune system components pertaining to inflammation in chapter eight. They have also discussed anti-inflammatory mechanisms underlying nontraditional pathways of these proteins, including adiponectin’s AMPKindependent signaling pathway and estrogen’s effects via its membrane receptor.

In the last chapter by Miguel A. Tejedor-Alonso et al. a comprehensive review is presented of the use of epinephrine in anaphylaxis episodes both by patients and by the emergency services.

I hope that the readers will find these reviews valuable and thought provoking so that they trigger further research in the quest for the development of pharmacological agents used for the treatment of allergies.

I am grateful for the timely efforts made by the editorial personnel, especially Mahmood Alam (Director Publications), Taimur A. Khan and Maria Baig at Bentham Science Publishers.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
University of Cambridge
UK




Contributor(s):
André Moreira
Allergy, Asthma and Sports Unit
Immunoallergology Department Porto
Centro Hospitalar São João, E.P.E.
Portugal; Immunology Lab
Faculty of Medicine
University of Porto
Porto
Portugal


Aylin Türel Ermertcan
Celal Bayar University
Faculty of Medicine
Department of Dermatology
Manisa
Turkey


Bárbara Cases
Institute of Applied Molecular Medicine (IMMA) and San Pablo CEU University
School of Medicine of Madrid
Jiménez Díaz Foundation (IIS-FJD) of Madrid
Research and Development Department of Inmunotek S.L
Madrid
Spain


Carlos Pastor-Vargas
Institute of Applied Molecular Medicine (IMMA) and San Pablo CEU University
School of Medicine of Madrid
Jiménez Díaz Foundation (IIS-FJD) of Madrid
Research and Development Department of Inmunotek S.L
Madrid
Spain


Diana Silva
Allergy, Asthma and Sports Unit
Immunoallergology Department Porto
Centro Hospitalar São João, E.P.E.
Porto
Portugal


Eva Perez-Rodriguez
Hospital Universitario Ntra. Sra. De Candelaria
Allergy and Immunology Service
Canary Islands
Tenerife
Spain


Halyna Siomyk
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Harit Parakandi
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Hossam Shahin
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Hui Jia
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Javier Estarita
Internal Medicine Department
National University
Bogotá
Colombia


Jianli Zhao
Department of Anesthesiology
the First Affiliated Hospital and Department of Physiology
Shanxi Medical University
Thomas Jefferson University
Shanxi
Taiyuan
China


Jorge Sánchez
GACE, Group of Clinical and Experimental Allergy
University of Antioquia
Medellín
Colombia


Juan Antonio Martinez-Tadeo
Hospital Universitario Ntra. Sra. De Candelaria
Allergy and Immunology Service
Canary Islands
Tenerife
Spain


Luís Delgado
Allergy, Asthma and Sports Unit
Immunoallergology Department
Centro Hospitalar São João, E.P.E.
Portugal; Immunology Lab
Faculty of Medicine
University of Porto
Porto
Portugal


Mar Moro-Moro
Allergy Unit of University Hospital Fundacion
Alcorcon
Spain


Maria V. Mugica-Garcia
Allergy Unit of University Hospital Fundacion
Alcorcon
Spain


Mariana Couto
Immunology Lab
Faculty of Medicine
University of Porto
Alameda Prof
Monteiro
Portugal


Marina Pérez-Gordo
Research and Development Department of Inmunotek S.L
Institute of Applied Molecular Medicine (IMMA) and San Pablo CEU University
School of Medicine of Madrid
Jiménez Díaz Foundation (IIS-FJD) of Madrid
Madrid
Spain


Mathew Samuel
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Michael Ret
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Miguel A Tejedor-Alonso
Allergy Unit of University Hospital Fundacion
Alcorcon
Spain


Naveen Arora
Allergy and Immunology Section
CSIR-Institute of Genomics and Integrative Biology
Delhi University Campus
India


Neena Philips
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Sagar Laxman Kale
Delhi University Campus
Allergy and Immunology Section
CSIR-Institute of Genomics and Integrative Biology
India


Sedef Bayata
Department of Dermatology
Celal Bayar University
Faculty of Medicine
Manisa
Turkey


Sesha Gopal
School of Natural Sciences
Fairleigh Dickinson University
Teaneck
NJ , 07666
USA


Wayne Bond Lau
Department of Anesthesiology
the First Affiliated Hospital and Department of Physiology
Shanxi Medical University
Thomas Jefferson University
Shanxi
Taiyuan
China


Yajing Wang
Department of Anesthesiology
the First Affiliated Hospital and Department of Physiology
Shanxi Medical University
Thomas Jefferson University
Shanxi
Taiyuan
China


Zulay Almeida-Sanchez
Hospital Universitario Ntra. Sra. De Candelaria
Allergy and Immunology Service
Canary Islands
Tenerife
Spain




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