Frontiers in Anti-Cancer Drug Discovery

Volume 2

by

Atta-ur-Rahman, M. Iqbal Choudhary

DOI: 10.2174/97816080580821130201
eISBN: 978-1-60805-808-2, 2013
ISBN: 978-1-60805-809-9
ISSN: 1879-6656 (Print)



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Indexed in: Scopus, EMBASE

Frontiers in Anti-Cancer Drug Discovery is an Ebook series devoted to publishing the latest and the most important advances in Anti-Ca...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Ferid Murad

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Preface

- Pp. ii-iv (3)

Atta-ur-Rahman and M. Iqbal Choudhary

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List of Contributors

- Pp. v-viii (4)

Atta-ur-Rahman and M. Iqbal Choudhary

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HER2 Over-Expression and Gastric Cancer: Molecular Mechanisms and Target Therapies

- Pp. 3-31 (29)

Michael Luis and Ramon A. de Mello

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Dietary Phenolics as Cancer Chemopreventive Nutraceuticals: A Promising Paradigm

- Pp. 32-92 (61)

Mohammad F. Ullah, Showket H. Bhat, Eram Hussain, Faisel Abu-Duhier, Husain Y. Khan, Mohammad Aatif, Aamir Ahmad and Sheikh M. Hadi

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Flavonoids and their Therapeutic Potential as Anti Cancer Agents: Mechanism, Factors and Regulation

- Pp. 93-138 (46)

Priya Batra, Rajesh Naithani and Anil K. Sharma

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Antibody-Drug Conjugates as Therapeutic Agents in Oncology: Overview And Perspectives

- Pp. 139-189 (51)

Milos Dokmanovic, Mohammed K. ElZarrad, Dianne S. Hirsch and Wen J. Wu

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Strategies for Improving the Systemic Delivery of Oncolytic Adenoviruses and Plasmids: Potential Application of Non-Viral Carriers

- Pp. 190-225 (36)

Mireia Agirre, Jon Zarate, Gustavo Puras, Luis A. Rojas, Ramon Alemany and José L. Pedraz

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Peptidyl-Prolyl Isomerase Pin1: A Novel Target for Cancer Therapy

- Pp. 226-263 (38)

Rohit Mathur, Anant N. Bhatt, Seema Gupta and Bilikere S. Dwarakanath

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Targeting the Molecular Circuitry Underlying Glioblastoma Invasion

- Pp. 264-281 (18)

Sean M. Lawless, Johnny C. Akers, Chun-Lin Chen, Rui Liu, Bob Carter and Clark C. Chen

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State-of-the-Art Nanopharmaceutical Drug Delivery Platforms for Antineoplastic Agents

- Pp. 282-368 (87)

Georgi Ts. Momekov, Denitsa B. Momekova, Plamen T. Peykov and Nikolay G. Lambov

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Index

- Pp. 369-377 (9)

Atta-ur-Rahman and M. Iqbal Choudhary

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Foreword

Frontiers in Anti-cancer Drug Discovery covers important advances in the field of drug development with particular focus on research on drugs in advanced stages of development, clinical trials and applications. This Volume published under the editorship of Prof. Atta-ur-Rahman aims at providing readers with an update on contemporary research. The research articles are comprehensive and have been written by an impressive group of authors, most of whom are well known for their own contributions in the field of drug research.

This eBook should be of significant interest to Ph.D. students and established researchers. I commend the editor, Prof. Atta-ur-Rahman, and all the contributors for this well written volume which highlights the quest for a cure for cancer.

Ferid Murad
(Nobel Prize Physiology and Medicine 1998)
University Professor and Director of the Cell
George Washington University
Washington
USA


Preface

Cancer remains second leading cause of death, after cardiovascular diseases. Efforts to understand cancer at the molecular level have led to the emergence of many new disciplines at the interface of chemistry and biology. The discovery of new molecular targets and new molecular entities which can modulate the molecular functions, combined with the advent of enabling technologies for early diagnosis and disease progression, as well as better drug delivery vehicles, create a new hope for the treatment of most cancers, if not all, in the near future. The eBook entitled “Frontiers in Anti-Cancer Drug Discovery”, is an excellent show case of the various approaches the researchers are undertaking to address the issue of cancer prevention and treatment. All chapters, with the exception of chapters 2 and 3, address a distinct issue and provide research based solutions.

Chapter 1 contributed by Michael Luis and Ramon Andrade de Mello, reviews the importance of human epidermal growth factor receptor 2 (HER2) as a potential target for the treatment of the second most common cancer type, gastric cancer. The authors support their hypothesis of HER2 as an important target for drug discovery and development by numerous studies, conducted in recent past. HER2 and its role in gastric cancer progression and development of resistance against cancer chemotherapies are presented in a reader friendly manner.

Chapter 2 and 3 contributed by Mohammad F. Ullah et al., and Priya Batra et al., respectively, highlight the importance of natural products in cancer chemoprevention and treatment. Chapter 2 provides an excellent overview of scientific and clinical studies conducted on cancer’s preventive role of dietary phenolics. They have mentioned the examples of various well known plant phenolic constituents, obtained from fruits and dietary herbs, and describe their chemopreventive role by modulating the essential cellular pathways involved in cancer proliferation and metastasis. In chapter 3, the authors have also focused on a class of plant phenolics, flavonoids of dietary origin and reviewed their possible action in the prevention and treatment of various cancers. Interactions of plant-based flavonoids with proteins and other dietary components are also reviewed.

Chapter 4 contributed by Milos Dokmanovic et al., focuses on an emerging class of therapeutics, anti-body drug conjugates (ADC). The authors have taken a holistic view of the topic by describing the history, current status of development and future prospects. These recent developments have made it possible to use ADC as serious candidates for cancer treatment. The results of recent clinical trials and synthetic strategies to develop novel ADCs have also been nicely described in this chapter.

Mireia Agirre et al., in chapter 5 address the potential and prospects of virotherapy against cancer. This new approach, though it has suffered from a lot of technical hurdles, now appears to be practical and promising. Specially interesting is the fact that synthetic viruses have the capacity to manipulate aderoviruses to target cancer cells. This makes the field scientifically exciting and therapeutically promising.

Chapter 6 by Rohit Mathur et al., identifies peptidyl-prolyl isomerase PIN1 as a novel target for cancer treatment. PIN1 up-regulation in tumor cell and its role in protein post phosphorylation events makes it an attractive target for drug discovery. PIN1 inhibitors as anti-cancer agents and as adjuvants deserve special attention.

Sean M. Lawless et al., review the details of molecular cascade involved in the glioblastoma invasion in chapter 7. Glioblastoma is among the deadliest of human cancers with an amazing tendency to invade other regions of the brain. The authors have reviewed the molecular mechanisms involved in glioblastoma invasion and identified numerous molecular targets for possible drug development.

Last but not least, chapter 8 contributed by Georgi Ts. Momekov et al., reviews an exciting development in drug delivery. The use of nanopharmaceutical agents holds great promise. Drug delivery vehicles with nanoparticles not only have improved therapeutic indices but also improved stability and solubility and lower toxicity associated with cancer chemotherapy.

This delightful feast of well written scientific articles on topics of general relevance, makes this book a “must to read” for practitioners, scientists, and students. We must thank the contributing authors for making this volume an important treatise of scientific knowledge. We are also profoundly grateful to the editorial staff, particularly Mr. Mahmood Alam (Director Publication) and Ms. Hira Aftab (Assistant Manager) for their hard work and persistent efforts.

Prof. Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

&

Prof. M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
University of Karachi
Karachi-75270
Pakistan

List of Contributors

Editor(s):
Prof. Atta-ur-Rahman
Honorary Life Fellow, Kings College
University of Cambridge
UK


Prof. M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Pakistan




Contributor(s):
Priya Batra
Department of Biotechnology
Maharishi Markandeshwar University
Mullana-Ambala, 133203
India


Rajesh Naithani
Cancer Research Centre
Himalayan Institute and Hospital Trust
UK
India


Anil K. Sharma
Department of Biotechnology
Maharishi Markandeshwar University
Mullana-Ambala, 133203
India


Michael Luis
Department of Medical Oncology
Portuguese Oncology Institute
Rua Dr. António Bernardino de Almeida
Porto, 4200-072
Portugal


Ramon Andrade de Mello
Department of Medical Oncology
Portuguese Oncology Institute
Rua Dr. António Bernardino de Almeida
Porto, 4200-072
Portugal


Rohit Mathur
Department of Lymphoma/Myeloma
The University of Texas MD Anderson Cancer Center
Houston
Texas, 77030
USA


Anant N. Bhatt
Division of Radiation Biosciences
Institute of Nuclear Medicine and Allied Sciences
Delhi, 110054
India


Seema Gupta
Department of Radiation Oncology
University of Miami
Miami
Florida, 33136
USA


B.S. Dwarakanath
Division of Radiation Biosciences
Institute of Nuclear Medicine and Allied Sciences
Delhi, 110054
India


Sean M. Lawless
Center for Theoretical and Applied Neuro-Oncology
Moores Cancer Center, School of Medicine
University of California at San Diego
La Jolla
CA
USA


Johnny C. Akers
Center for Theoretical and Applied Neuro-Oncology
Moores Cancer Center, School of Medicine
University of California at San Diego
La Jolla
CA
USA


Chun-Lin Chen
Center for Theoretical and Applied Neuro-Oncology
Moores Cancer Center, School of Medicine
University of California at San Diego
La Jolla
CA
USA


Rui Liu
Department of Neurosurgery
Navy General Hospital of People's Liberation Army
Beijing, 100037
China


Bob Carter
Center for Theoretical and Applied Neuro-Oncology
Moores Cancer Center, School of Medicine
University of California at San Diego
La Jolla
CA
USA


Clark C. Chen
Center for Theoretical and Applied Neuro-Oncology
Moores Cancer Center, School of Medicine
University of California at San Diego
La Jolla
CA
USA


Georgi Ts. Momekov
Faculty of Pharmacy
Medical University-Sofia
2 Dunav Str.
Sofia, 1000
Bulgaria


Denitsa B. Momekova
Faculty of Pharmacy
Medical University-Sofia
2 Dunav Str.
Sofia, 1000
Bulgaria


Plamen T. Peykov
Faculty of Pharmacy
Medical University-Sofia
2 Dunav Str.
Sofia, 1000
Bulgaria


Nikolay G. Lambov
Faculty of Pharmacy
Medical University-Sofia
2 Dunav Str.
Sofia, 1000
Bulgaria


Mohammad F. Ullah
Department of Medical Laboratory Technology
Faculty of Applied Medical Sciences
University of Tabuk
Tabuk, 71491
KSA


Showket H. Bhat
Department of Medical Laboratory Technology
Faculty of Applied Medical Sciences
University of Tabuk
Tabuk, 71491
KSA


Eram Hussain
Department of Medical Laboratory Technology
Faculty of Applied Medical Sciences
University of Tabuk
Tabuk, 71491
KSA


Faisel Abu-Duhier
Department of Medical Laboratory Technology
Faculty of Applied Medical Sciences
University of Tabuk
Tabuk, 71491
KSA


Husain Y. Khan
Department of Biochemistry
Faculty of Life Sciences, AMU
Aligarh
(U.P.), 202002
India


Mohammad Aatif
Department of Biochemistry
Faculty of Life Sciences, AMU
Aligarh
(U.P.), 202002
India


Aamir Ahmad
Department of Pathology, Barbara Ann Karmanos Cancer Institute
Wayne State University School of Medicine
Hudson Webber Cancer Research Center
Detroit
MI, 48201
USA


S. M. Hadi
Department of Biochemistry
Faculty of Life Sciences, AMU
Aligarh
(U.P.), 202002
India


Milos Dokmanovic
Laboratory of Molecular Oncology, Division of Monoclonal Antibodies
Office of Biotechnology Products, Office of Pharmaceutical Science
Center for Drug Evaluation and Research, U.S. Food and Drug Administration
Bethesda
Maryland
USA


M. Khair ElZarrad
Laboratory of Molecular Oncology, Division of Monoclonal Antibodies
Office of Biotechnology Products, Office of Pharmaceutical Science
Center for Drug Evaluation and Research, U.S. Food and Drug Administration
Bethesda
Maryland
USA


Dianne S. Hirsch
Laboratory of Molecular Oncology, Division of Monoclonal Antibodies
Office of Biotechnology Products, Office of Pharmaceutical Science
Center for Drug Evaluation and Research, U.S. Food and Drug Administration
Bethesda, Maryland
USA


Wen Jin Wu
Laboratory of Molecular Oncology, Division of Monoclonal Antibodies
Office of Biotechnology Products, Office of Pharmaceutical Science
Center for Drug Evaluation and Research, U.S. Food and Drug Administration
Bethesda, Maryland
USA


Mireia Agirre
NanoBioCel Group
University of the Basque Country
Vitoria
Spain


Jon Zarate
NanoBioCel Group
University of the Basque Country
Vitoria
Spain


Gustavo Puras
NanoBioCel Group
University of the Basque Country
Vitoria
Spain


Luis Alfonso Rojas
Traslational Research laboratory
IDIBELL-Institut Català d´Oncologia
L´Hospitalet de Llobregat
Barcelona
Spain


Ramon Alemany
Traslational Research laboratory
IDIBELL-Institut Català d´Oncologia
L´Hospitalet de Llobregat
Barcelona
Spain


José Luis Pedraz
NanoBioCel Group
University of the Basque Country
Vitoria
Spain




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