Frontiers in Clinical Drug Research-Hematology

Volume 1

by

Atta-ur-Rahman

DOI: 10.2174/97816080585871140101
eISBN: 978-1-60805-858-7, 2014
ISBN: 978-1-60805-859-4
ISSN: 2352-3239

  
  




Frontiers in Clinical Drug Research – Hematology is an eBook series that brings updated reviews to readers interested in learning abou...[view complete introduction]
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Table of Contents

Preface, Pp. i-ii (2)

Atta-ur-Rahman
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List of Contributors, Pp. iii-iv (2)

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Is a Protective Microenvironment the “Achille’s Heel” in Chronic Lymphocytic Leukemia?, Pp. 3-41 (39)

Paolo Giannoni and Daniela de Totero
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Epigenetic Drugs in Myelodysplastic Syndrome and the Leukemias, Pp. 42-61 (20)

Jacob Peedicayil
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Myeloproliferative Neoplasms – Molecular Biology and Potential Targets for Intervention, Pp. 62-102 (41)

Martin H. Bonamino, Barbara Monte-Mor, Cristiana Solza and Ilana Zalcberg
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Thalidomide, Bortezomib and Lenalidomide – Three Drugs that Changed Multiple Myeloma, Pp. 103-178 (76)

Jiri Minarik and Vlastimil Scudla
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Application of Molecular Imaging for Drug Discovery and Development in Hematology Research, Pp. 179-224 (46)

Pengfei Xu, Min Liu, Xiaobo Wang, Zhiguo Liu, Weimin Miao and Wenbin Zeng
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Recent Advances in the Treatment of β-Thalassemia Major, Pp. 225-276 (52)

Manju Mamtani and Hemant Kulkarni
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Integrating Computational Methods, Molecular Docking, and Molecular Dynamics Simulation Approaches Towards Personalized Medicine in Hematological Disorders, Pp. 277-325 (49)

George Priya Doss C and Chiranjib Chakraborty
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Treatment with Acetylsalicylic Acid in Neurological Disorders – Old Drug, New Uses, Pp. 326-362 (37)

Maria Lukasik and Slawomir Michalak
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Index, Pp. 363-378 (16)

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Preface

Frontiers in Clinical Drug Research: Hematology is an eBook series that brings updated reviews to readers interested in advances in the development of pharmaceutical agents for the treatment of hematological disorders. The chapters in this volume of the eBook series are written by leading authors in their respective fields. There are several hematology related topics in this introductory volume covering in silico methods in hematology drug design, beta-thalassemia major, multiple myeloma, leukemia and more.

Chapter 1 and 2 covers research specifically on leukemia. The first chapter by Giannoni and de Totero presents findings about the in vivo microenvironment surrounding cells responsible for chronic lymphocytic leukemia. The second chapter is a review of epigenetic drugs used in leukemia and myelodysplastic syndrome. Specifically, two categories of drugs are presented, namely DNA methyltransferase inhibitors (DNMTi) and histone deacetylase inhibitors (HDACi).

Bonamino et al. in chapter 3, provides a comprehensive review on the molecular and genetic mechanisms involved in the onset and treat of myeloproliferative neoplasms. In Chapter 4, Minarik and Scudla review the history of multiple myeloma, focusing on treatment with three agents - Thalidomide, Bortezomib and Lenalidomide - drugs which have arguably changed the standards used to treat this dsease.

In chapter 5 of this volume, Xu et al. have summarized recent advances in the application of molecular imaging techniques employed in drug research in hematology. The article also highlights the different stages of the research process where such techniques can prove to be very useful for investigators.

In chapter 6, Mamtani and Kulkarni have presented a review on several treatments for β-thalassemia Major. The review covers a number of pharmacological agents that reduce tissue iron deposition as well as diagnostic methods based on MRI techniques for the early detection of iron overload. This chapter also accounts for some advances in β-thalassemia genomic research.

In chapter 7 of the eBook, Chakraborty and Priya Doss review computer based approaches such as SNP mapping and study of epigenetic marker variation in the ABL1 gene. These have paved the way for computational methods for treating patients on a personalized regimen.

Chapter 8, written by Lukasik and Michalak, summarizes the use of acetylsalicylic acid (aspirin) in the treatment of cerebrovascular disorders.

I hope that readers will find value in this collection of reviews and draw inspiration for conducting further drug discovery research in the field of hematology.

I am grateful for the timely efforts made by the editorial personnel, especially Mr. Mahmood Alam (Director Publications), Ms. Maria Baig (Manager Publications) and Mr. Taimur at Bentham Science Publishers for their assistance.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman FRS
Kings College
University of Cambridge
UK




Contributor(s):
Barbara Monte-Mor
Laboratório de Biologia Molecular
Centro de Transplante de Medula Óssea (CEMO)
Instituto Nacional de Câncer (INCA)
Brazil


Chiranjib Chakraborty
Department of Bioinformatics
School of Computer and Information Sciences
Galgotias University
Greater Noida
India


Cristiana Solza
Universidade do Estado do Rio de Janeiro (UERJ),
Brazil


Daniela de Totero
Transfer Gene Lab, IRCCS San Martino Hospital-National
Institute for Cancer Research (IST) Largo R. Benzi, 10
Genoa, 16132
Italy


George Priya Doss C
Medical Biotechnology Division
School of Biosciences and Technology
VIT University
Vellore
Tamil Nadu, 632014
India


Hemant Kulkarni
Lata Medical Research Foundation
Nagpur
TX
India


Ilana Zalcberg
Laboratório de Biologia Molecular
Centro de Transplante de Medula Óssea (CEMO)
Instituto Nacional de Câncer (INCA)
Brazil


Jacob Peedicayil
Department of Pharmacology and Clinical Pharmacology
Christian Medical College
Vellore
India


Jiri Minarik
Department of Internal Medicine III
University Hospital Olomouc
Czech Republic


Manju Mamtani
Lata Medical Research Foundation
Nagpur
TX
India


Maria Lukasik
Department of Neurology
Poznan University of Medical Sciences
Poznan
Poland


Martin H. Bonamino
Coordenação de Pesquisa – Instituto Nacional de Câncer (INCA)
Brazil


Paolo Giannoni
Stem Cell Laboratory
Advanced Biotechnology Center
Largo R. Benzi, 10
Genoa, 16132
Italy


Slawomir Michalak
Department of Neurology
Poznan University of Medical Sciences
Poznan
Poland


Vlastimil Scudla
Department of Internal Medicine III
University Hospital Olomouc
Czech Republic




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