Anti-Angiogenesis Drug Discovery and Development

Volume 2

by

Atta-ur-Rahman, FRS , M. Iqbal Choudhary

DOI: 10.2174/97816080586621140201
eISBN: 978-1-60805-866-2, 2014
ISBN: 978-1-60805-867-9
ISSN: 2452-3240 (Print)
ISSN: 2210-268X (Online)



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The inhibition of angiogenesis is an effective mechanism of slowing down tumor growth and malignancies. The process of induction or pr...[view complete introduction]

Table of Contents

Preface

- Pp. i-iii (3)

Atta-ur-Rahman

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List of Contributors

- Pp. iv-vi (3)

Atta-ur-Rahman

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Mechanism of Controlling Blood Vessel Growth and Development and Identification of Therapeutics Against Pathological Angiogenesis

- Pp. 3-62 (60)

Sheetal Parida and Mahitosh Mandal

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Development of In Vitro Method for Assaying Anti-Angiogenic Effect of Drugs

- Pp. 63-111 (49)

Masumi Akita

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Clear Cell Renal Cell Carcinoma as a Model of Pathological Angiogenesis: Which Actors to Target for Treatment?

- Pp. 112-131 (20)

Caroline Hilmi and Gilles Pagès

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Inhibition of Angiogenesis in Cancer Management by Antioxidants: Ascorbate and P. leucotomos

- Pp. 132-146 (15)

Neena Philips, Halyna Siomyk, Hui Jia and Harit Parakandi

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Development of Novel Anti-Cancer Strategies Based on Angiogenesis Inhibition

- Pp. 147-190 (44)

Rajiv P. Gude, Prachi Patil, Mohammad Zahid Kamran and Peeyush N. Goel

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Discovery and Development of Antiangiogenetic Drugs in Ovarian Cancer

- Pp. 191-215 (25)

Madon M. Maile, Evelyn Y. T. Wong, Daphne Suzin, Nicole E. Birrer and Richard T. Penson

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STAT3 Signaling in Cancer: Small Molecule Intervention as Therapy?

- Pp. 216-267 (52)

John S. McMurray and Jim Klostergaard

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Anti-Angiogenic Therapy and Cardiovascular Diseases: Current Strategies and Future Perspectives

- Pp. 268-308 (41)

Vasiliki K. Katsi, Costas T. Psarros, Marios G. Krokidis, Georgia D. Vamvakou, Dimitris Tousoulis, Christodoulos I. Stefanadis and Ioannis E. Kallikazaros

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Index

- Pp. 309-314 (6)

Atta-ur-Rahman

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Preface

Angiogenesis is one of the most important processes in the life cycles of higher animals, both in normal physiology, and in pathophysiology. The growth of new blood vessels modulates many processes including reproduction and development of cells, wound heating, etc. The molecular cascade of angiogenesis is tightly regulated by inhibitors and stimulators. Upregulation and disruption of angiogenic factors play key roles in the tumor growth and metastasis. Angiogenesis is also a key actor in cancer and other diseases. The discovery of angiogenic inhibitors is a promising approach for the treatment of various diseases, including cancers. The modern research in this area takes benefit of the understanding of angiogenisis at the molecular level. Key targets has been identified, and a large number of small molecular inhibitors have been discovered, which influence the angiogenic pathway in a very subtle manner. The developments in this field are fast and exciting, and deserve attention of both the drug discovery scientists, and the general public.

Volume 2 of this ebook series entitled, “Anti-angiogenesis Drug Discovery and Development”, is an outstanding collection of well written articles in this important field. The first volume of this series was greatly appreciated by the readers. The second volume is a continuation of the some high quality compilation of focused articles.

The first review by Parida and Mandal focuses on defining the complex mechanism of angiogenesis, and the recent advances in therapeutics which target the process at various points. These drugs and drugs candidates interact with various targets in the angiogenic cascade, and generate considerable disease response. Akita in his review describes various in vitro assays / bioassays, used in the discovery of anti-angiogenic agents. These range from culturing techniques to capillary tube degradation and cell migration. The objective is to punitively assess the anti-angiogenic effects of drug candidates.

Hilmi and Pagès have reviewed various targets in angiogenesis in clear cell renal carcinoma (CCRCC). CCRCC is widely used for the study of the implications of angiogenesis in cancer. This has been taken as a model to understand the process of angiogenesis at molecular and cellular levels as well as to understand which of these targets can yield optimal therapeutic response. The success and failure of various antiagiogenic agents in clinical practices has also been reviewed. Oxidative stress plays an important role in the on-set of many diseases. In cancer progression, oxidative stress is the primary cause of the up-regulation of several pro-angiogenic factors. Philips et al have contributed an excellent review on the role of antioxidants, both single molecules as well as plant extracts, and their combination, as supplement regimen to inhibit the invasiveness of several cancers. Gude et al have reviewed studies on novel anti-cancer strategies, based on striking the balance between pro-angiogenic and anti-angiogenic molecules. They have also summarized various molecules of both synthetic and natural origins which inhibit the process of angiogenesis and can be used for the treatment of cancers. Ovarian cancer is among the most lethal malignancies. Currently the available drugs are less than adequate for its treatment. The discovery of new antiangiogenics can open the way for better treatment, and improve overall survival in ovarian cancer. Maile at al has attributed an excellent review on this topic. Mc Murray and Klostergaard present a well referenced review on STAT3 (Signal Transducer and activator of Transcription 3) and its role in angiogenesis. STAT3 signaling activation has been identified as a valid target for drug discovery. Inhibition of STAT3 activation is achieved by inhibiting the interaction between the tumor cells and stromal compartment. The review summarizes decades of research work on small molecule-mediated inhibition of STAT3.

Katsi has written an excellent treatise on another aspect of angiogenesis, related to cardiovascular diseases such as an atherosclerosis. Historical prospects and details of the latest developments of angiogenesis therapies for cardiovascular diseases are reviewed.

This volume is the result of hard work of so many eminent contributors, for which we express our profound gratitude. We also like to acknowledge the commitment and untiring efforts of the outstanding team of the Bentham Science Publishers, led by Mr. Mahmood Alam, Director Bentham Science Publishers. The efforts of Ms. Sara Yasir, Manager Publications, deserve special appreciation.

Atta-ur-Rahman, FRS
Kings College
University of Cambridge
Cambridge
UK

List of Contributors

Editor(s):
Atta-ur-Rahman, FRS
Honorary Life Fellow
Kings College
University of Cambridge
UK


M. Iqbal Choudhary
H.E.J. Research Institute of Chemistry
International Center for Chemical and Biological Sciences
University of Karachi
Karachi
Pakistan




Contributor(s):
Caroline Hilmi
University of Nice Sophia Antipolis
Institute for Research on Cancer and Ageing of Nice
UMR CNRS 7284
INSERM U1081
France


Christodoulos I. Stefanadis
1st Cardiology Department
Athens University Medical School
Greece


Costas T. Psarros
1st Cardiology Department
Athens University Medical School
Greece


Daphne Suzin
Massachusetts General Hospital
Virginia Commonwealth University
Boston
MA
USA


Dimitris Tousoulis
1st Cardiology Department
Athens University Medical School
Greece


Evelyn Y. T. Wong
Yong Loo Lin School of Medicine
Singapore


Georgia D. Vamvakou
Second Department of Cardiology
University of Athens
Attikon Hospital
Chaidari
Greece


Gilles Pagès
University of Nice Sophia Antipolis
Institute for Research on Cancer and Ageing of Nice
UMR CNRS 7284
INSERM U1081
France


Halyna Siomyk
Professor of Biology
School of Natural Sciences
Fairleigh Dickinson University
Teaneck, NJ 07666
USA


Harit Parakandi
Professor of Biology
School of Natural Sciences
Fairleigh Dickinson University
Teaneck, NJ 07666
USA


Hui Jia
Professor of Biology
School of Natural Sciences
Fairleigh Dickinson University
Teaneck, NJ 07666
USA


Ioannis E. Kallikazaros
Cardiology Department
Hippokration Hospital
Athens
Greece


Jim Klostergaard
Molecular and Cellular Oncology
The University of Texas
MD Anderson Cancer Center
Houston
TX USA


John S. McMurray
Departments of Experimental Therapeutics and Molecular and Cellular Oncology
The University of Texas
MD Anderson Cancer Center
Houston
TX USA


Madon M. Maile
Massachusetts General Hospital
Boston
MA
USA


Mahitosh Mandal
School of Medical Science and Technology
Indian Institute of Technology
Kharagpur
West Bengal
India


Marios G. Krokidis
1st Cardiology Department
Athens University Medical School
Greece


Masumi Akita
Division of Morphological Science
Biomedical Research Center
Saitama Medical University
38 Moroyama
Iruma-gun
Japan


Mohammad Zahid Kamran
Gude Lab
Advanced Centre for Treatment Research and Education in Cancer (ACTREC)
Tata Memorial Centre
Navi-Mumbai
Kharghar
India


Neena Philips
Professor of Biology
School of Natural Sciences
Fairleigh Dickinson University
Teaneck, NJ 07666
USA


Nicole E. Birrer
Massachusetts General Hospital
Boston
MA
USA


Peeyush N. Goel
Gude Lab
Advanced Centre for Treatment Research and Education in Cancer (ACTREC)
Tata Memorial Centre
Navi-Mumbai
Kharghar
India


Prachi Patil
Gude Lab
Advanced Centre for Treatment Research and Education in Cancer (ACTREC)
Tata Memorial Centre
Navi-Mumbai
Kharghar
India


Rajiv P. Gude
Gude Lab
Advanced Centre for Treatment Research and Education in Cancer (ACTREC)
Tata Memorial Centre
Navi-Mumbai
Kharghar
India


Richard T. Penson
Massachusetts General Hospital
Boston
MA
USA


Sheetal Parida
School of Medical Science and Technology
Indian Institute of Technology
Kharagpur
West Bengal
India


Vasiliki K. Katsi
Cardiology Department
Hippokration Hospital
Athens
Greece




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