Medicinal Chemistry - Fusion of Traditional and Western Medicine, Second Edition


by

Robert E. Smith

DOI: 10.2174/97816080597441140201
eISBN: 978-1-60805-974-4, 2014
ISBN: 978-1-60805-975-1



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Medicinal Chemistry - Fusion of Traditional and Western Medicine is a textbook intended for students taking courses in...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Mark D. Pilley

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Preface

- Pp. ii

Robert E. Smith

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Introduction

- Pp. 3-108 (106)

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Biotechnologies for Medicinal Chemists

- Pp. 109-127 (19)

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Developing New Drugs

- Pp. 128-162 (35)

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How New Drugs Are Developed: Kinetics Evaluations

- Pp. 163-222 (60)

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How New Drugs Are Developed: Toxicology

- Pp. 223-251 (29)

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How New Drugs Are Developed: Improve the Lead Compound

- Pp. 252-272 (21)

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How New Drugs Are Developed: Drug Delivery

- Pp. 273-282 (10)

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How New Drugs Are Developed: Manufacturing and cGMP

- Pp. 283-329 (47)

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How New Drugs Are Investigated

- Pp. 330-341 (12)

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Drugs That Inhibit Enzymes

- Pp. 342-389 (48)

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Drugs That Interact with Receptors and Ion Channels

- Pp. 390-415 (26)

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Drugs That Target Transporters, Carriers and Ion Pumps

- Pp. 416-424 (9)

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Drugs That Act on Microtubules

- Pp. 425-451 (27)

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Drugs That Target or Use DNA or RNA

- Pp. 452-468 (17)

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Appendix

- Pp. 469-536 (68)

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Subject Index

- Pp. 537-545 (9)

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Foreword

As a practicing physician, I found this second edition to be very up-to-date, interesting and useful. It would be an excellent text book for the first semester in the standard two-semester course taught at most pharmacy schools. Much of it describes concepts and metabolic processes for which there was limited knowledge or was completely unknown when I was a medical student. The information presented provides undergraduate, medical and pharmacy students with useful information about the indications for and applications of modern medicinal chemistry. It will also help currently licensed physicians prepare for Board certification and recertification. Many of the old questions may have new answers. For example, 30 years ago, it was believed that genetic information could flow only from DNA to RNA to proteins, or that patients could not have an autoimmune disease. Thirty years ago the correct answers would have been yes – now they are no! I also found the book to be very helpful in describing medicines that I currently prescribe to patients and new drugs that are being developed. On frequent occasions, a patient will ask, “Why aren’t doctors doing more to find cures for common diseases”. The information in this book provides useful answers. I am also frequently asked questions about nutrition, dietary supplements and environmental toxins. The information about these subjects was written in clear, simple language that most people can understand. Other important and useful information regards the environmental toxin and endocrine disruptor, bisphenol A, or BPA. The popular literature and mass media debate whether microgram quantities of BPA in plastic products are harmful, but they ignore the milligram quantities of BPA that are found in most receipts that you get from ATM machines and cash registers. It is especially important to not let infants put such paper in their mouths as they explore the world orally or make spit wads in school as adolescents. It could harm their reproductive development. So, the book is very readable and has a multi-disciplinary approach. It teaches the kind of things that I would like to see medical and pharmacy students learn and could even be useful to lay people.

Mark D. Pilley
Omaha
NE 68124-3135
USA


Preface

This book was written as a textbook for the first semester in a two-semester a course in medicinal chemistry that is taught in most pharmacy schools. It can be used in standard courses for pharmacy students and for students who are trying to get into medical, dental, pharmacy or graduate school. “Moreover, people working in the pharmaceutical industry and doctors preparing for Medical Board Exams will also find it useful” [1]. “Since new drugs are being developed by multi-disciplinary teams, this book” [1] has a multi-disciplinary approach. Chemists, biologists, physicians, mathematicians, engineers and computer scientists will read some things that are familiar to them and they will learn about each other’s disciplines. It describes the new paradigm that is “emerging in modern biology, biochemistry and medicine. It is a fusion of traditional and western medicine and between systems thinking and reductionist thinking” [1]. The important newly discovered roles of epigenetics and different types of RNA are discussed at length. This edition tells “how new drugs are investigated, developed and eventually approved by the FDA” [1]. Although most currently approved drugs were developed based on their abilities to affect a single therapeutic target, new drugs will affect many targets simultaneously. Instead of binding to the active site of a single enzyme, allosteric inhibitors will partially inhibit many targets simultaneously and have far fewer harmful side effects. It also talks about high throughput screening and data mining to look for new chemical entities that might become new drugs. The chapter on pharmacokinetics and toxicokinetics has been expanded, as have other chapters. Drugs that target enzymes, membrane bound receptors, DNA, microtubules, RNA, ion pumps and transporters are described, along with ways to improve the lead compound through rational drug design. The book talks about cGMP, GLP and the regulatory process. It describes the analytical methods that are used to verify that the right drug has been made and that no impurities are present. It also has chapters on toxicology, nutrition and dietary supplements. Finally, this book and the topics discussed in it should not be taken as reflecting FDA policy or regulations.

ACKNOWLEDGEMENTS

Declared none.

CONFLICT OF INTEREST

The author confirms that this ebook contents have no conflict of interest.

REFERENCE

[1] Smith RE. Medicinal Chemistry – Fusion of Traditional and Western Medicine. Bentham Science. Sharjah, UAE, 2013.

Robert E. Smith
Park University
Chemistry Department
8700 NW River Park Drive Parkville, MO 64152
USA
Email: Robert.Smith05@park.edu

List of Contributors

Author(s):
Robert E. Smith
Park University
USA




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