Thrombosis and Inflammation in Acute Coronary Syndromes


by

Ertugrul Ercan, Gulfem Ece

DOI: 10.2174/97816810802911150101
eISBN: 978-1-68108-029-1, 2015
ISBN: 978-1-68108-030-7



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Despite remarkable progress in fighting against myocardial infarction, the thrombotic complications of the coronary artery are still a...[view complete introduction]

Table of Contents

Foreword

- Pp. i

Lale Tokgozoglu

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Preface

- Pp. ii

Ertugrul Ercan and Gulfem Ece

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List of Contributors

- Pp. v

Ertugrul Ercan and Gulfem Ece

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Circulating Biomarkers of Vulnerable Atheromatous Plaques

- Pp. 3-21 (19)

Xinkang Wang

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Tissue Factor Structure and Coagulation

- Pp. 23-57 (35)

Jolanta Krudysz-Amblo, Kenneth G. Mann and Saulius Butenas

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Hemostasis: General Principles

- Pp. 59-66 (8)

Melda Comert, Fahri Sahin and Guray Saydam

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Recurrent Thromboembolism

- Pp. 67-77 (11)

Melda Comert, Guray Saydam and Fahri Sahin

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Antiplatelet Resistance

- Pp. 79-103 (25)

Dilek Ural, İrem Yılmaz and Kurtuluş Karaüzüm

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Platelet Inhibitors for the Treatment of Acute Coronary Syndromes

- Pp. 105-120 (16)

Hasan Gungor and Ceyhun Ceyhan

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Antiplatelet and Antithrombotic Therapy in Acute Coronary Syndrome in Patients with Chronic Kidney Disease

- Pp. 121-139 (19)

Mahmut Altındal and Mustafa Arıcı

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Infectious Pathogens in Acute Atherosclerosis

- Pp. 141-151 (11)

Gulfem Ece

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Subject Index

- Pp. 153-154 (2)

Ertugrul Ercan and Gulfem Ece

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Foreword

Atherosclerotic vascular disease is the leading cause of mortality in most parts of the world. Even with the most optimistic projections, it is expected to increase in the next decade. Although we have come a long way in preventing cardiovascular deaths, treating acute coronary syndromes and undertanding the biology of the disease, there is still much to learn. The accumulation of information in the field of thrombosis and atherosclerosis is immense. This book is a timely update on the new mechanisms and new approaches to treatment in the field. It is a useful resource to the clinician who wants to understand the mechanism and use the novel therapeutic approaches. An effort has been made to explain the basis of our therapeutic approaches. I hope this comprehensive book will be useful to the clinician.

Lale Tokgozoglu
Hacettepe University
Ankara
Turkey


Preface

This textbook covers many of the essential topics in the area of cardiovascular medicine. Pathophysiology of hemostasis and thrombosis are discussed extensively to make clear explanations for concepts behind thrombosis and heart disease. Mechanisms of thrombosis; the roles of cells, cytokines, and inflammation in the pathogenesis of cardiovascular diseases; and the evidence justifying current antithrombotic therapy are discussed under the light of latest multicenter, randomized clinical trials. Physiology, pathology and treatment of coronary artery thrombosis, the safety and efficacy of new heparins, direct thrombin inhibitors, glycoprotein IIb/IIIa inhibitors, new antiplatelet drugs, and new thrombolytic agents are mentioned. The coverage of trials focuses primarily on acute coronary syndromes. Coronary intervention (PCI) has become a well accepted therapy for stenotic coronary artery disease. Diagnostic and therapeutic interventions for coronary arterial disease are summarized with effective use of figures and tables. This book appeals to cardiologists, generalists, internists, family physicians, medical residents, and students. The emphasis are both practical and clinical. There are no heavy discussions of basic science or molecular mechanisms. Complex clinical trials are summarized but not dissected in detail.

Ertugrul Ercan
Izmir University
Faculty of Medicine
Department of Cardiology Medicalpark Hospital
35000 Izmir-Turkey

&

Gulfem Ece
Izmir University
School of Medicine
Medicalpark Hospital
Department of Medical Microbiology
35000 Izmir-Turkey

List of Contributors

Editor(s):
Ertugrul Ercan


Gulfem Ece




Contributor(s):
Mahmut Altindal
Department of Nephrology
Hacettepe University Faculty of Medicine
Ankara
Turkey


Jolanta Krudyszt Amblo
Department of Biochemistry Burlington
University of Vermont
Vermont
USA


Mustafa Arıcı
Department of Nephrology
Hacettepe University Faculty of Medicine
Ankara
Turkey


Saulius Butenas
Department of Biochemistry Burlington
University of Vermont
Vermont
USA


Ceyhun Ceyhan
Department of Cardiology
Adnan Menderes University School of Medicine
Aydin
Turkey


Melda Comert
Department of Hematology
Ege University School of Medicine
Izmir
Turkey


Gulfem Ece
Izmir University School of Medicine
Medicalpark Hospital Department of Medical Microbiology
Izmir
Turkey


Ajda Gunes Ersoy
Department of Hematology
Ege University School of Medicine
Izmir
Turkey


Hasan Gungor
Department of Cardiology
Adnan Menderes University School of Medicine
Aydin
Turkey


Kurtulus Karauzum
Kocaeli University School of Medicine Department of Cardiology
Kocaeli
Turkey


Kenneth G. Mann
Department of Biochemistry Burlington
University of Vermont
Vermont
USA


Fahri Sahin
Department of Hematology
Ege University School of Medicine
Izmir
Turkey


Guray Saydam
Department of Hematology
Ege University School of Medicine
Izmir
Turkey


Dilek Ural
Kocaeli University School of Medicine Department of Cardiology
Kocaeli
Turkey


Xinkang Wang
Translational Science
Agennix Inc.
Princeton
NJ 08540
USA


Irem Yilmaz
Kocaeli University School of Medicine Department of Cardiology
Kocaeli
Turkey




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